Synthesis of pyrrolo[1,2-a]quinolines by formal 1,3-dipolar cycloaddition reactions of quinolinium salts.

Quinolinium salts, Q+-CH2-CO2Me Br- and Q+-CH2-CONMe2 Br- (where Q = quinoline), were prepared from quinolines. Deprotonation of these salts with triethylamine promoted the reaction of the resulting quinolinium ylides (formally azomethine ylides) with electron-poor alkenes by conjugate addition followed by cyclization or by [3 + 2] dipolar cycloaddition. The pyrroloquinoline products were formed as single regio- and stereoisomers. These could be converted to other derivatives by Suzuki-Miyaura coupling, reduction or oxidation reactions.

Implications of an exemplar-theoretic model of phoneme genesis: a velar palatalization case study.

Diachronic velar palatalization is taken as the case study for modeling the emergence of a new phoneme category. The spread of a palatalized variant through the lexicon is treated as a stochastic classification task for the listener/learner. The model combines two measures of similarity to determine classification within an exemplar-theoretic framework: acoustic distance and phonotactic expectation. There are three model outcomes: contrast, allophony, or contextual neutralization between the plain and palatalized velars. It is shown, through a series of simulations, that these can be predicted from the distribution of sounds within the pre-change lexicons, namely, the ratio of the /k-vowel/ sequences containing naturally palatalizing vowels (i, I, e), to those containing non-palatalizers. "Unnatural" phonotactic associations can arise in individual lexicons, but are sharply limited due to the large size of the lexicon and the local nature of the phoneme changes. "Anti-natural" distributions, which categorically violate the proposed implicational relationship between palatalization and frontness/height, are absent. This work provides an explicit and restrictive model of phoneme change. The results also serve as an existence proof for an outcome-blind mechanism of avoiding over-generation.

Mobilizing knowledge about urban change for equity and sustainability: developing 'Change Stories', a multi-country transdisciplinary study.

Background: Health-focused research funders increasingly support multi-country research partnerships that study health, urban development and equity in global settings. To develop new knowledge that benefits society, these grants require researchers to integrate diverse knowledges and data, and to manage research-related aspects of coloniality, such as power imbalances and epistemic injustices. We conducted research to develop a transdisciplinary study proposal with partners in multiple middle and high income countries, aiming to embed equity into the methodology and funding model. Methods: Parallel to literature review, we used participatory and social research methods to identify case study cities for our primary study and to inform our study design. We conducted semi-structured interviews with informed and consented sustainable urban development experts in the USA (n=23). We co-developed our research approach with our global advisory group (n=14) and conducted a participatory workshop (n=30) to identify case study sites, also informed by conversations with international academic experts in sustainable development (n=27). Results: Through literature review we found that there is a need to study the contextual pre-conditions of urban transformation, the influence of coloniality on understandings of how cities can change and the failure of standard development practices to meet the needs of all residents and the planet. Through expert input and literature we found that decolonial and storytelling methods may help us show the complexities behind stories of urban transformation, particularly the role of marginalized populations in creating long-term change. Conclusions: There are multiple benefits of conducting research to develop an equitably designed multi-country research collaboration. We built new partnerships and co-developed our research approach, creating new understanding of diverse collaborators' disciplinary perspectives and institutional requirements. By investigating the informational needs of U.S. sustainable development actors and designing our study to meet these needs, we have increased the likelihood that our research will create impact.

Project title: Mobilizing knowledge about urban change for equity and sustainability: developing 'Change Stories', a multi-country transdisciplinary study. Our team initially included researchers in London and later expanded to include international collaborators with expertise in urban development, public health and anthropology. This project was primarily conducted through online workshops and interviews (May ­ Dec 2022), with one in-person workshop in Valencia, Spain (Oct 2022). Research funders have recently increased support for multi-country partnerships that study urban health equity. However, there is often a lack of funding to develop these studies in a way that supports integration of diverse fields and manages research-related aspects of coloniality, such as power imbalances and devaluing certain forms of knowledge. We conducted research to develop a transdisciplinary study proposal with partners in multiple countries, aiming to embed equity into our approach. We used literature review alongside social research methods (94 participants) to develop case study cities and our study design. We found that community involvement in urban governance is important for achieving equity and health, yet it remains under-valued in status quo development models, undermining the potential for cities to support people and the planet. We believe that our approach offers valuable learning for other multi-country transdisciplinary studies.

A Reanalysis of the Voicing Effect in English: With Implications for Featural Specification.

The voicing effect is among the most studied and robust of phonetic phenomena. Yet there remains a lack of consensus on why vowels preceding voiced obstruents should be longer than vowels preceding voiceless obstruents. In this paper we provide an analysis of the voicing effect in a corpus of natural speech, and using production data from a metronome-timed word repetition study. From this evidence, as well as the existing literature, we conclude that vowel duration differences follow from consonant duration differences. The characteristic voicing effect in English is largely limited to words of especially long duration, and preceding vowel duration does not reliably cue obstruent voicing under the following circumstances: when obstruent voicing or duration cues conflict; for lax or unstressed vowels; and for most conversational speech. We show that this behavior can be modeled using a competing-constraints framework, where all segments resist expanding or compressing past a preferred duration. Inherent segment elasticity determines the degree of resistance, but segment duration is ultimately determined by the interaction of these segmental constraints with constraints on the distribution of the lengthening force within the syllable, and how closely target durations are matched. This account of the voicing effect has a number of implications for phonological theory, especially the central role that the concept of prominence plays in the analysis of underlying features.

Healthy energy-efficient housing: using a one-touch approach to maximize public health, energy, and housing programs and policies.

Housing conditions such as leaky roofs, peeling paint, structural problems, chronic dampness, improperly vented combustion appliances, and poor ventilation can cause injury, illness, and increased energy consumption. Homes with moderate and severe housing hazards are more likely to be occupied by families with limited incomes because of the lack of affordable housing choices. As a result, children and older adults in these communities face disproportionate impacts from these housing hazards, including higher asthma and injury rates, greater prevalence of lead poisoning, and higher household energy burdens. Programs and policies addressing home health and energy issues have historically operated in categorical silos, which in turn cause fragmented service delivery and inefficient use of scarce resources by the agencies providing these services. A "one-touch" approach for home interventions that strategically integrates public health and energy efficiency has many potential direct and indirect benefits. Also, this approach plays an important role in housing policy due to the increasing support for green housing and residential energy efficiency.

A systematic review of housing interventions and health: introduction, methods, and summary findings.

Subject matter experts systematically reviewed evidence on the effectiveness of specific housing interventions in improving health. The panelists reviewed housing interventions associated with exposure to biological and chemical agents, structural injury hazards, and community-level interventions. Intervention studies were grouped together according to recommendations in the Guide to Community Preventive Services, which identifies similarities in the type of intervention, its delivery and setting, and the target population. Review panelists found that 11 interventions had sufficient evidence of effectiveness, 15 required more field evaluation, 19 needed formative research, and 7 either had no evidence of effectiveness or were ineffective. Although many housing conditions are associated with adverse health outcomes, sufficient evidence now shows that specific housing interventions can improve certain health outcomes. The results of these evidence reviews can inform a robust agenda for widespread implementation and further research. This article highlights the project's research methods and summary findings, and its companion articles detail the evidence reviews for specific housing interventions.

Housing interventions at the neighborhood level and health: a review of the evidence.

A panel of subject matter experts systematically reviewed evidence linking neighborhood-level housing interventions, such as housing programs or policies, to health outcomes. One of the 10 interventions reviewed--the Housing Choice Voucher Program--had sufficient evidence for implementation or expansion. The evidence showed that voucher holders are less likely to suffer from overcrowding, malnutrition due to food insecurity, and concentrated neighborhood poverty than non-voucher holders. Of the other reviewed interventions, 2 needed more field evaluation and 7 needed more formative research. None were determined to be ineffective. Although many of the reviewed interventions lacked sufficient evidence for widespread implementation solely based on their health benefits, this evidence review shows that many interventions positively affect other areas of social, economic, and environmental well-being. Efforts to improve neighborhood environments and to maintain and increase the number of affordable housing units are critical to ensuring safe, healthy, and affordable housing for all people in the United States. Given that people of color disproportionately reside in high-poverty neighborhoods, neighborhood-level interventions may be particularly important in efforts to eliminate health disparities.

Housing interventions and control of asthma-related indoor biologic agents: a review of the evidence.

Subject matter experts systematically reviewed evidence on the effectiveness of housing interventions that affect health outcomes, primarily asthma, associated with exposure to moisture, mold, and allergens. Three of the 11 interventions reviewed had sufficient evidence for implementation: multifaceted, in-home, tailored interventions for reducing asthma morbidity; integrated pest management to reduce cockroach allergen; and combined elimination of moisture intrusion and leaks and removal of moldy items to reduce mold and respiratory symptoms. Four interventions needed more field evaluation, 1 needed formative research, and 3 either had no evidence of effectiveness or were ineffective. The 3 interventions with sufficient evidence all applied multiple, integrated strategies. This evidence review shows that selected interventions that improve housing conditions will reduce morbidity from asthma and respiratory allergies.

Mold and endotoxin levels in the aftermath of Hurricane Katrina: a pilot project of homes in New Orleans undergoing renovation.

BACKGROUND: After Hurricane Katrina, many New Orleans homes remained flooded for weeks, promoting heavy microbial growth. OBJECTIVES: A small demonstration project was conducted November 2005-January 2006 aiming to recommend safe remediation techniques and safe levels of worker protection, and to characterize airborne mold and endotoxin throughout cleanup. METHODS: Three houses with floodwater lines between 0.3 and 2 m underwent intervention, including disposal of damaged furnishings and drywall, cleaning surfaces, drying remaining structure, and treatment with a biostatic agent. We measured indoor and outdoor bioaerosols before, during, and after intervention. Samples were analyzed for fungi [culture, spore analysis, polymerase chain reaction (PCR)] and endotoxin. In one house, realtime particle counts were also assessed, and respirator-efficiency testing was performed to establish workplace protection factors (WPF). RESULTS: At baseline, culturable mold ranged from 22,000 to 515,000 colony-forming units/m3, spore counts ranged from 82,000 to 630,000 spores/m3, and endotoxin ranged from 17 to 139 endotoxin units/m3. Culture, spore analysis, and PCR indicated that Penicillium, Aspergillus, and Paecilomyces predominated. After intervention, levels of mold and endotoxin were generally lower (sometimes, orders of magnitude). The average WPF against fungal spores for elastomeric respirators was higher than for the N95 respirators. CONCLUSIONS: During baseline and intervention, mold and endotoxin levels were similar to those found in agricultural environments. We strongly recommend that those entering, cleaning, and repairing flood-damaged homes wear respirators at least as protective as elastomeric respirators. Recommendations based on this demonstration will benefit those involved in the current cleanup activities and will inform efforts to respond to future disasters.

The relationship between housing and health: children at risk.

In November 2002, the National Center for Healthy Housing convened a 2-day workshop to review the state of knowledge in the field of healthy housing. The workshop, supported with funds from the U.S. Centers for Disease Control and Prevention's National Center for Injury Prevention and Control and National Center for Environmental Health, was unique in that it focused solely on the effect of housing on children's health and the translation of research findings into practical activities in home construction, rehabilitation, and maintenance. Participants included experts and practitioners representing the health, housing, and environmental arenas. Presentations by subject-matter experts covered four key areas: asthma, neurotoxicants, injury, and translational research. Panel discussions followed the presentations, which generated robust dialogue on potential future research opportunities and overall policy gaps. Lack of consensus on standard measurements, incomplete understanding about the interaction of home hazards, inadequate research on the effectiveness of interventions, and insufficient political support limit current efforts to achieve healthy housing. However, change is forthcoming and achievable. Key words: asthma, childhood exposure, environmental toxicants, healthy housing, lead poisoning.

Rochester's lead law: evaluation of a local environmental health policy innovation.

BACKGROUND: Significant progress has been made in reducing the incidence of childhood lead poisoning in the United States in the past three decades. However, the prevalence of elevated blood lead in children (≥ 10 µg/dL) remains high in some communities, particularly those with high proportions of pre-1978 housing in poor condition. Increasingly, municipalities are using local policy tools to reduce lead poisoning in high-risk areas, but little is known about the effectiveness of such policies. OBJECTIVES: In this article, we evaluated the effectiveness of a comprehensive rental housing-based lead law adopted in Rochester, New York, in 2005. METHODS: This policy evaluation integrates analyses of city inspections data, a survey of landlords, landlord focus groups, and health department data on children's blood lead levels from the first 4 years of implementation of the 2005 law. RESULTS: Implementation has proceeded consistent with projected numbers of inspections with nearly all target units inspected in the first 4 years. Higher than expected inspection passage rates suggest that landlords have reduced lead hazards in rental housing affected by the law. Implementation of the lead law does not appear to have had a significant impact on the housing market. CONCLUSIONS: Although many uncertainties remain, our analysis suggests that the lead law has had a positive impact on children's health. Strong enforcement, support for community-based lead programs, and ongoing intergovernmental coordination will be necessary to maintain lead-safe housing in Rochester. Lessons learned from the Rochester experience may inform future local lead poisoning prevention policies in other communities.

Evaluation of the effects of ethanol on static and dynamic gait.

OBJECTIVE: We used two balance assessment devices, computerized dynamic posturography (CDP) and Swaystar transducers to detect subtle balance system deficits in nine subjects who had ingested minimal amounts of alcohol. DESIGN: Nine subjects were evaluated with both modalities before, and repetitively after, ingesting a small amount of alcohol. METHODS: We measured condition 5 (sway referenced platform; eyes closed) on CDP and tandem walking with eyes closed while wearing Swaystar to see if either test could detect a balance deficit. MAIN OUTCOME MEASURES: We measured total sway amplitude with eyes closed in pitch and roll planes during tandem walking with Swaystar, and static balance scores of CDP sensory organization testing condition 5 before and after alcohol ingestion at 20 min intervals. RESULTS: Although there was no detectable deficit measurable by CDP, eight of our nine subjects showed increased dynamic sway as measured by Swaystar, after alcohol ingestion. Total sway was significantly greater (p=.05) after alcohol ingestion. CONCLUSION: It is important to assess dynamic, rather than static, equilibrium as it may have potential in detecting very subtle balance deficits.

Foreign body aspiration in infants and toddlers: recent trends in British Columbia.

OBJECTIVES: The objectives of this study were to (1) examine recent trends in the demographics and presentation of children with foreign body aspiration at British Columbia's Children's Hospital and (2) develop safety guidelines regarding feeding nuts and other hard, crunchy foods to infants and toddlers. METHODS: The methods used were a retrospective chart review and a review of swallowing mechanics in early childhood. RESULTS: Between July 1997 and July 2001, 51 children under 3 years of age underwent rigid bronchoscopy for suspected foreign body aspiration. Of these patients, 27 (53%) were 18 months of age or younger. Of these 27 infants and toddlers, 24 (89%) had a witnessed choking event and 22 (81%) had an airway foreign body. Nuts, raw carrots, and popcorn kernels accounted for 14 (64%) of the foreign bodies aspirated by these infants and toddlers. Before 2 years of age, children are poorly equipped to grind and swallow hard, crunchy food because they lack second molars and are still adjusting to the descent of the larynx. CONCLUSIONS: Infants and toddlers in British Columbia have been aspirating foreign bodies at an alarmingly high rate. Most cases would have been prevented with better public awareness. Caregivers should be informed that children under 3 years of age should never be fed nuts or other hard, crunchy foods. A public awareness campaign is warranted.