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Int J Radiat Biol ; 100(4): 609-618, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38190436

RESUMEN

PURPOSE: The current study aimed to investigate boron carbide and boric acid nanoparticles (NPs) as absorbents for thermal neutrons and high-density polyethylene (HDPE) as a substrate and neutron moderator for fast neutrons. The goal was to assess the performance of boron carbide and boric acid NPs based on HDPE as a nanoshield of photoneutrons from medical linear accelerators. MATERIALS AND METHODS: This study was conducted in two parts of simulation and practice. The Monte Carlo (MC) simulation involved modeling and verification of the single-layer, double-layer, and combined nanoshields by selecting nanomaterials and substrates and, finally, calculating the macroscopic cross-sections. The practical part involved manufacturing nanoshields based on the simulation results and evaluating the manufactured nanocomposites via experimental measurements. RESULTS: MC simulation results with an uncertainty of less than 1% showed that for the monolayer samples, the best result belonged to boron carbide at a concentration of 10% and a macroscopic cross-section of 0.933 cm-1. At a concentration of 20%, the highest value among the double-layer samples was 0.936 cm-1 and for the combined samples, this value was 0.928 cm-1. Boron carbide single-layer nanocomposites at a 10% concentration, as well as the bilayer nanoshield of 10% boron carbide and 20% boric acid performed well; however, the best performance belonged to the nanoshield with a macroscopic cross-section of 0.960 and the combination containing 5% boron carbide and 10% boric acid. CONCLUSIONS: The research suggests that utilizing boron carbide and boric acid nanoshields in combination with HDPE holds promise as a viable approach to protecting from the photoneutrons. Further exploration of these nanocomposite shields and their practical applications is warranted, with the potential to yield significant advancements in radiation therapy safety and efficacy.


Asunto(s)
Ácidos Bóricos , Terapia por Captura de Neutrón de Boro , Nanopartículas , Polietileno , Boro , Compuestos de Boro , Neutrones , Aceleradores de Partículas , Método de Montecarlo , Terapia por Captura de Neutrón de Boro/métodos
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