RESUMEN
The study of intergenerational income mobility has witnessed more visibility in academic and public policy circles in light of the new estimates generated by Chetty and colleagues. The distribution of race-based estimates of intergenerational income mobility demonstrates strong spatial patterning, such that the success of a child's traversal to the top income quintile in the United States is spatially conditioned and dependent on locality. However, research drawing on the new estimates of intergenerational income mobility has largely taken an aspatial approach. This study is the first attempt to develop an explicitly spatial model, demonstrating that the determinants of place-based mobility vary both geographically and across racial groups. By systematically accounting for spatial autocorrelation and heterogeneity, we identify the race- and region-specific determinants of intergenerational income mobility across counties in the United States.
RESUMEN
BACKGROUND: Hyper-immunoglobulin M (HIGM) syndrome is a rare heterogeneous group of primary immunodeficiency disorders characterized by low or absent serum levels of IgG and IgA along with normal or elevated serum levels of IgM. METHODS: Clinical and immunological data were collected from the 75 patients' medical records diagnosed in Children's Medical Center affiliated to Tehran University Medical Sciences and other Universities of Medical Sciences in Iran. Among 75 selected patients, 48 patients (64%) were analyzed genetically using targeted and whole-exome sequencing. RESULTS: The ratio of male to female was 2.9:1. The median age at the onset of the disease, time of diagnosis, and diagnostic delay were 10.5, 50, and 24 months, respectively. Pneumonia and lower respiratory tract infections (61.3%) were the most common complications. Responsible genes were identified in 35 patients (72.9%) out 48 genetically analyzed patients. Cluster of differentiation 40 ligand gene was the most mutated gene observed in 24 patients (68.5%) followed by activation-induced cytidine deaminase gene in 7 patients, lipopolysaccharide-responsive and beige-like anchor (1 patient), nuclear factor-kappa-B essential modulator (1 patient), phosphoinositide-3-kinase regulatory subunit 1 (1 patient), and nuclear factor kappa B subunit 1 (1 patient) genes. Nineteen (25.3%) patients died during the study period, and pneumonia was the major cause of death occurred in 6 (31.6%) patients. CONCLUSION: Physicians in our country should carefully pay attention to respiratory tract infections and pneumonia, particularly in patients with a positive family history. Further investigations are required for detection of new genes and pathways resulting in HIGM phenotype.