Wage inequality and poverty effects of lockdown and social distancing in Europe.

Social distancing and lockdown measures taken to contain the spread of COVID-19 may have distributional economic costs beyond the contraction of GDP. Here we evaluate the capacity of individuals to work under a lockdown based on a Lockdown Working Ability index which considers their teleworking capacity and whether their occupation is essential or closed. Our analysis reveals substantial and uneven potential wage losses across the distribution all around Europe and we consistently find that both poverty and wage inequality rise in all European countries. Under four different scenarios (2 months of lockdown and 2 months of lockdown plus 6 months of partial functioning of closed occupations at 80%, 70% and 60% of full capacity) we estimate for 29 European countries an average increase in the headcount poverty index that goes from 4.9 to 9.4 percentage points and a mean loss rate for poor workers between 10% and 16.2%. The average increase in the Gini coefficient ranges between 3.5% to 7.3% depending on the scenario considered. Decomposing overall wage inequality in Europe, we find that lockdown and social distance measures produce a double process of divergence: both inequality within and between countries increase.

Lockdown, Earnings Losses and Household Asset Buffers in Europe.

Measures taken to contain the spread of COVID-19 affected some workers' capability to work and hence earning more than others. The initial impact may have been mitigated, for instance by relying on savings and assets, but access to these buffers likely varied within and across countries. In this article we estimate COVID-19 potential earnings losses using the Lockdown Working Ability Index and relate this to households' savings and assets observed in the Eurosystem Household Finance and Consumption Survey. We find that, without government support, households in the Euro Area could only offset on average half of their losses by relying on liquid assets and almost half would deplete their savings in doing so, although there is significant cross-country variation. When considering the effect of income support policies, liquid assets cover on average 65 percent of the remaining losses and still 20 percent would exhaust their liquid assets on average in the Euro Area.

Mycobacterium tuberculosis strains of the Beijing genotype are rarely observed in tuberculosis patients in South America.

The frequency of the Beijing genotype of Mycobacterium tuberculosis as a cause of tuberculosis (TB) in South America was determined by analyzing genotypes of strains isolated from patients that had been diagnosed with the disease between 1997 and 2003 in seven countries of the subcontinent. In total, 19 of the 1,202 (1.6%) TB cases carried Beijing isolates, including 11 of the 185 patients from Peru (5.9%), five of the 512 patients from Argentina (1.0%), two of the 252 Brazilian cases (0.8%), one of the 166 patients from Paraguay (0.6%) and none of the samples obtained from Chile (35), Colombia (36) and Ecuador (16). Except for two patients that were East Asian immigrants, all cases with Beijing strains were native South Americans. No association was found between carrying a strain with the Beijing genotype and having drug or multi-drug resistant disease. Our data show that presently transmission of M. tuberculosis strains of the Beijing genotype is not frequent in Latin America. In addition, the lack of association of drug resistant TB and infection with M. tuberculosis of the Beijing genotype observed presently demands efforts to define better the contribution of the virulence and lack of response to treatment to the growing spread of Beijing strains observed in other parts of the world.

Characterization of Mycobacterium chelonae-Like Strains by Comparative Genomics.

Isolates of the Mycobacterium chelonae-M. abscessus complex are subdivided into four clusters (CHI to CHIV) in the INNO-LiPA® Mycobacterium spp DNA strip assay. A considerable phenotypic variability was observed among isolates of the CHII cluster. In this study, we examined the diversity of 26 CHII cluster isolates by phenotypic analysis, drug susceptibility testing, whole genome sequencing and single-gene analysis. Pairwise genome comparisons were performed using several approaches, including average nucleotide identity (ANI) and genome-to-genome distance (GGD) among others. Based on ANI and GGD the isolates were identified as M. chelonae (14 isolates), M. franklinii (2 isolates) and M. salmoniphium (1 isolate). The remaining 9 isolates were subdivided into three novel putative genomospecies. Phenotypic analyses including drug susceptibility testing, as well as whole genome comparison by TETRA and delta differences, were not helpful in separating the groups revealed by ANI and GGD. The analysis of standard four conserved genomic regions showed that rpoB alone and the concatenated sequences clearly distinguished the taxonomic groups delimited by whole genome analyses. In conclusion, the CHII INNO-LiPa is not a homogeneous cluster; on the contrary, it is composed of closely related different species belonging to the M. chelonae-M. abscessus complex and also several unidentified isolates. The detection of these isolates, putatively novel species, indicates a wider inner variability than the presently known in this complex.

Predictive value of direct nitrate reductase assay and its clinical performance in the detection of multi- and extensively drug-resistant tuberculosis.

Conventional culture and drug susceptibility testing (DST) methods for Mycobacterium tuberculosis are laborious and time consuming. For this reason alternative rapid culture and DST techniques are urgently needed to shorten the time for drug-resistance detection. A total of 222 smear-positive sputum samples were evaluated by the direct nitrate reductase assay (D-NRA) on Lowenstein-Jensen medium, for the rapid and simultaneous detection of resistance to isoniazid, rifampicin, kanamycin and ofloxacin. p-Nitrobenzoic acid was also included for identification of the M. tuberculosis complex. Results were compared with the BACTEC MGIT 960 as gold standard. The general performance of the D-NRA was very good, reaching a global value of 97 %. D-NRA had a turn-around time of 16.9 days to obtain results while that of the indirect MGIT 960 system was 29 days. D-NRA is a low-cost technology, easy to set up in clinical laboratories and suitable to be used for DST of M. tuberculosis in all smear-positive samples.

Tratamiento exitoso de síndrome hemofagocítico secundario a infección por virus de Epstein Barr: Reporte de caso / Successful treatment of hemophagocytic syndrome secondary to Epstein-Barr virus infection: Report of a case

Se presenta el caso de un paciente varón de seis años de edad, con síndrome hemofagocítico secundario a infección por virus de Epstein-Barr. El paciente inició el cuadro con fiebre, hepatoesplenomegalia, falla hepática, trastornos de la coagulación, ferritina, triglicéridos y disminución de todas las líneas celulares hematológicas. El aspirado de médula ósea evidenció la presencia de citofagocitosis, por lo que inició tratamiento específico según protocolo HLH 2004, respondiendo favorablemente luego de cuatro semanas. Actualmente, el paciente continúa sus controles por la especialidad sin recaída de enfermedad, con adecuado desarrollo y crecimiento. En nuestro país, son escasos los reportes de síndrome hemofagocítico; sin embargo, puede resultar una patología más frecuente de la que estimamos por lo que, es importante reportar estos casos y más aún el éxito del tratamiento a fin de continuar mejorando su manejo y reporte.

We present the case of a six-year old male patient who presented with hemophagocytic syndrome secondary to Epstein Barr virus infection. The patient had fever, hepatosplenomegaly, liver failure, coagulation, ferritin, and triglyceride disorders, as well as a significant reduction of all blood cell populations. Bone marrow aspirate revealed the presence of autophagocytosis, so specific therapy according to the HLH 2004 protocol was started, and the patient satisfactorily responded after four weeks. Nowadays the patient still attends his control appointments, no relapse has been detected, and both his development and growth are adequate. Few reports on hemophagocytic syndrome have been published in Peru; however, this condition may be more frequent than previously thought. Therefore, it is important to report such cases, particularly successful experiences, aiming to improve management of this condition.

Relación entre el estado nutricional y los grados de ausentismo laboral en trabajadores de dos empresas peruanas / Relationship between nutritional status and level of work absenteeism in workers of two Peruvian companies during the year 2013

Objetivo: Determinar la relación entre el estado nutricional y los grados de ausentismo laboral. Materiales y métodos: El diseño del estudio fue de tipo transversal. Se recolectó la información a través de las historias clínicas tras el examen médico ocupacional y el registro de las ausencias durante todo el año 2013. Se utilizó estadística descriptiva para el cálculo de la frecuencia y regresión logística para la obtención de los factores asociados. Resultados: Ingresaron 545 trabajadores. Al incrementarse la edad se incrementan las frecuencias de sobrepeso y obesidad. Las complicaciones asociadas al incremento de peso: hipertensión arterial (48,8%), diabetes mellitus tipo 2 (57,1%), dislipidemia (54,5%) y los trastornos musculo esqueléticos (61,9%) se presentan con mayor frecuencia en los trabajadores con sobrepeso, el valor de 28 kg/m2 tuvo la mayor significancia estadística para explicar la relación entre el índice de masa corporal (IMC) incrementado y grados de ausentismo (p=0,01). Conclusiones: El sobre peso está relacionado con mayores índices de ausentismo, específicamente al de mediano plazo. Un IMC de 28 kg/m2 se asocia a un incremento significativo del ausentismo, y los trastornos osteomusculares son los modifican de manera sustancial la relación entre ausentismo e incremento de peso

Objective: To determine the relationship between nutritional status and the levels of absenteeism in the workplace. Materials and methods: This was a cross-sectional study. The information was collected from the medical records after the occupational medical check-up and by reviewing all absences in the workplace during 2013. Descriptive statistics were used for calculating the rates and logistic regression for obtaining the associated factors. Results: Five hundred and forty-five workers were included in the study. The rates of being overweight and obese increased with age. Complications associated with weight gain were: high blood pressure (48.8%), type 2 diabetes (57.1%), dyslipidemia (54.5%) and skeletal muscle disorders (61.9%), which occur more often in overweight workers. The value of 28 Kg/ m2 had the highest statistical significance for explaining the relationship between an increased BMI and the rates of absenteeism in the workplace (p= 0.01). Conclusions: Being overweight is linked to higher rates of absenteeism, specifically in the medium term. A 28- Kg/m2 BMI is associated with a significant increase in absenteeism in the workplace, and musculoskeletal disorders substantially modify the relationship between absenteeism and weight gain

Mycobacterium tuberculosis strains of the Beijing genotype are rarely observed in tuberculosis patients in South America

The frequency of the Beijing genotype of Mycobacterium tuberculosis as a cause of tuberculosis (TB) in South America was determined by analyzing genotypes of strains isolated from patients that had been diagnosed with the disease between 1997 and 2003 in seven countries of the subcontinent. In total, 19 of the 1,202 (1.6 percent) TB cases carried Beijing isolates, including 11 of the 185 patients from Peru (5.9 percent), five of the 512 patients from Argentina (1.0 percent), two of the 252 Brazilian cases (0.8 percent), one of the 166 patients from Paraguay (0.6 percent) and none of the samples obtained from Chile (35), Colombia (36) and Ecuador (16). Except for two patients that were East Asian immigrants, all cases with Beijing strains were native South Americans. No association was found between carrying a strain with the Beijing genotype and having drug or multi-drug resistant disease. Our data show that presently transmission of M. tuberculosis strains of the Beijing genotype is not frequent in Latin America. In addition, the lack of association of drug resistant TB and infection with M. tuberculosis of the Beijing genotype observed presently demands efforts to define better the contribution of the virulence and lack of response to treatment to the growing spread of Beijing strains observed in other parts of the world.

Evaluation of phage assay for rapid phenotypic detection of rifampicin resistance in Mycobacterium tuberculosis / s. t

Conventional methods for susceptibility testing require several months before results can be reported. However, rapid methods to determine drug susceptibility have been developed recently. Phage assay have been reported as a rapid useful tools for antimicrobial susceptibility testing. The aim of this study was to apply the Phage assay for rapid detection of resistance on Mycobacterium tuberculosis strains in Cuba. Phage D29 assay was performed on 102 M. tuberculosis strains to detect rifampicin resistance. The results were compared with the proportion method (gold standard) to evaluate the sensitivity and specificity of Phage assay. Phage assay results were available in 2 days whereas Proportion Methods results were obtain in 42 days. A total of 44 strains were detected as rifampicin resistant by both methods. However, one strains deemed resistant by Proportion Methods was susceptible by Phage assay. The sensitivity and specificity of Phage assay were 97,8 percent and 100 percent respectively. Phage assay provides rapid and reliable results for susceptibility testing; it's easy to perform, requires no specialized equipment and is applicable to drug susceptibility testing in low income countries where tuberculosis is a major public health problem(AU)