1.
Metabol Open
; 14: 100176, 2022 Jun.
Artículo
en Inglés
| MEDLINE
| ID: mdl-35392380
RESUMEN
Overweight/obesity is a growing pandemic that affects many organs and tissues. We have investigated whether a high-lipid diet provokes an imbalance between type 1 and type 2 angiotensin II (Ang II) receptors signaling, leading to liver alterations associated with cardiovascular and kidney disturbances. Chronic administration of a high-lipid diet can provoke hepatocardiorenal syndrome resulting from activation of the Ang IIâtype 1 receptor axis, which is entirely counteracted by Ang-(3-4), the allosteric enhancer of the Ang IIâtype 2 receptor pathway.