Clinical and microbiological findings in patients with peri-implantitis: a cross-sectional study.

OBJECTIVE: The aim of this study was to analyze clinical and microbiological characters in subjects and implants affected and not affected by peri-implantitis. Additionally, same features were analyzed also intra-individually, comparing healthy and diseased implants within the same subject. MATERIALS AND METHODS: A total of 534 patients who received at least 1 implant and coming to routine check-up or spontaneous visits at the University of Valencia were recruited. Clinical parameters including Bleeding on probing (BoP), Probing pocket depth (PPD), and Pi were screened. Samples for microbiological analysis were obtained from three locations: peri-implant sulci (PIS), inner parts of the implant connections (I), and gingival sulci of neighboring teeth (GS). Quantitative real-time PCR was performed for total counts of 10 microorganisms. RESULTS: A total of 534 patients with 1507 dental implants were analyzed. The prevalence of peri-implantitis was found 10.3% for patients and 7.3% for implants. Higher percentage of healthy periodontal subjects were found in the non-peri-implantitis group. The analysis within the 53 patients affected by peri-implantitis revealed that the implants affected by peri-implantitis presented a higher percentage of plaque, BoP, and number of implants presenting <2 mm attached gingiva. Additionally, more cemented crowns and implants inserted in bone-augmented sites were found among the diseased implants. The microbiologic analysis presented no relevant differences between the analysis at the peri-implant sulcus (PIS) and the connections inside the abutments surfaces (PI). The microbial composition at the neighboring teeth (GS) resembled the composition found at the PIS with a high frequency of Pg, Tf, Pi, PM, and Ec. CONCLUSIONS: The results of this study seem to indicate that inadequate oral hygiene and the presence of bleeding from the gingiva/mucosa in patients with dental implant were associated with an higher prevalence of peri-implantitis; moreover, in the patients affected by peri-implantitis, the lack of sufficient height keratinized mucosa (<2 mm) and bone regenerative procedures at implant level were also associated to higher prevalence of peri-implantitis as well.

Surgical treatment of localized gingival recessions using coronally advanced flaps with or without subepithelial connective tissue graft.

BACKGROUND: A coronally advanced flap with subepithelial connective tissue graft is the gold standard surgical treatment of gingival recessions, since it offers a higher probability of achieving complete root coverage compared with other techniques. However, optimum short- and middle-term clinical results have also been obtained with coronally advanced flaps alone. The aim of the present study was to evaluate the results obtained by the surgical treatment of localized gingival recessions using coronally advanced flaps with or without subepithelial connective tissue graft. MATERIAL AND METHODS: The reduction of recession height was assessed, together with the gain in gingival attachment apical to the recession, and total reduction of recession, in a comparative study of two techniques. Twenty-two gingival recessions were operated upon: 13 in the control group (coronally advanced flap) and 9 in the test group (coronally advanced flap associated to subepithelial connective tissue graft). RESULTS: After 18 months, the mean reduction of recession height was 2.2 ± 0.8 mm in the control group and 2.3 ± 0.7 mm in the test group, with a mean gain in gingival attachment of 1.3 ± 0.9 mm and 2.3 ± 1.3 mm, respectively. In percentage terms, the mean reduction of recession height was 84.6 ± 19.6% in the control group and 81.7 ± 17.8% in the test group, with a mean gain in gingival attachment of 20.5 ± 37.4% and 184.4 ± 135.5%, respectively. CONCLUSIONS: Significant reduction of gingival recession was achieved with both techniques, though the mean gain in gingival attachment (in mm and as a %) was greater in test group.

Piezoelectric vs. conventional drilling in implant site preparation: pilot controlled randomized clinical trial with crossover design.

OBJECTIVE: To compare implant stability throughout osseointegration, peri-implant marginal bone loss, and success rates of implants placed with conventional and mixed drilling/piezoelectric osteotomy. MATERIALS AND METHODS: A pilot randomized-controlled trial was performed on 15 patients. Each patient received two implants in the mandibular molar region. All sites were prepared with conventionally up to the 2.8 mm wide drill. Osteotomies were randomly finalized with a 3 mm diameter drill (control group) or with two consecutive ultrasonic tips (2.8 mm and 3 mm wide, respectively) (test group). Resonance frequency analysis measurements were taken at implant placement and after 1, 3, 8, and 12 weeks. Peri-implant marginal bone loss 12 months after loading was calculated using periapical radiographs. Wilcoxon test for related samples was used to study differences in implant stability and in peri-implant marginal bone loss between the two groups. RESULTS: Twenty-nine of 30 implants osseointegrated successfully (one failure in the control group). Stability was significantly higher in the test group at the 8th week assessment; differences were non-significant at all other time-points. Longitudinally, differences were observed between the patterns of implant stability changes: in the test group stability increased more progressively, while in the control group an abrupt change occurred between the 8th and 12th weeks assessments. No difference was found in peri-implant marginal bone loss between the groups. All 29 implants were functionally successful at the 15-month visit. CONCLUSIONS: Within the limit of this pilot study (small sample size, short follow-up), data suggested that implant stability might develop slightly faster when implant site osteotomy is performed with a mixed drilling/ultrasonic technique.

Conventional radiofrequency treatment in five patients with trigeminal neuralgia.

INTRODUCTION: In trigeminal neuralgia, when drug treatment proves ineffective, other management options must be considered. In this context, conventional radiofrequency of Gasser's ganglion is a safe and effective alternative. MATERIAL AND METHODS: We describe 5 patients with long-evolving trigeminal neuralgia subjected to conventional radiofrequency according to the Sweet technique, with a follow-up of two years. RESULTS: Pain relief was complete after two months in all cases. One patient suffered an unexpected episode of nausea, vomiting and foul odor sensation that subsided after three days of rest and drug treatment. Three patients described non-painful hypoesthesia in the region of the treated nerve branch that subsided within three months. The patients remained free of symptoms over long-term follow-up. In one case the same radiofrequency technique had to be repeated after 21 months because of the reappearance of symptoms in the same zone, followed by immediate pain relief. CONCLUSIONS: In our series of patients trigeminal neuralgia was not controlled by drug treatment, and conventional radiofrequency targeted to Gasser's ganglion proved very effective, with no major complications.

Radiofrequency treatment of cervicogenic headache.

OBJECTIVES: In the clinical management of facial pain, a possible cervical origin must be considered. A clinical exploration is therefore essential. The disorder originates in the intimate connections between the cranial portion of the spinal cord and the trigeminal system. Although solid evidence supporting the use of radiofrequency (RF) treatment is lacking, it remains one of the management options to be taken into account. The present study evaluates the efficacy of RF in application to cervicogenic headache. STUDY DESIGN: We present three cases of severe facial pain arising from different cervical structures. RESULTS: In two cases the pain originated in cervical roots C2 and C3, while in the third patient the trigger point was located at the level of the atlantoaxial joint. Pulsed RF was applied for 4 minutes at the dorsal ganglion of C2 and C3 in the first two cases, and for 8 minutes at intraarticular level in the third patient. The pain gradually subsided during the first month in all cases. The first two patients reported 70% improvement after one month, 60% improvement after 6 months, and 30-50% after one year, versus baseline. The third patient reported complete pain resolution lasting approximately 5 months, after which the pain reappeared with the same intensity as before. CONCLUSIONS: Radiofrequency is a satisfactory treatment option, affording adequate analgesia, though the effects are sometimes temporary.

Rehabilitation of reabsorbed maxillae with implants in buttresses in patients with combination syndrome.

PURPOSE: To assess the success and marginal bone loss, after 1 year of loading, of implants placed in anatomic buttresses of atrophic maxillae to rehabilitate patients with combination syndrome. MATERIALS AND METHODS: A case series retrospective study of 22 patients with combination syndrome who were treated with implants in anatomic buttresses in the atrophic maxilla was performed. The inclusion criteria were Classes IV and V Cawood and Howell maxillary atrophy, rehabilitation with implants placed in anatomic buttresses, the presence of anterior remnant teeth in the mandible, and a minimum follow-up of 12 months after implant loading. The criteria of Buser et al were used to evaluate implant success, and marginal bone loss was measured on periapical radiographs. Statistical analysis was performed to relate implant success and marginal bone loss to gender, degree of maxillary atrophy, implant technique, and prosthesis type. RESULTS: A total of 18 patients fulfilled the inclusion criteria. A total of 117 implants were placed; 32 were placed with the conventional technique in the alveolar ridges with enough height and width, 35 were positioned palatally, 30 were tilted in the frontomaxillary buttress, 10 were placed in the pterygomaxillary area, 6 were placed in the nasopalatine canal, and 4 were zygomatic implants. The follow-up ranged from 1 to 7 years after implant loading. Of the 117 implants, 7 failed, for an implant success rate of 94%. The mean marginal bone loss was 0.63 mm. A statistically significant relation was found between bone loss and implant placement technique and the level of maxillary atrophy, being greater in tilted implants and in Class V Cawood and Howell maxillary atrophy. CONCLUSIONS: Implants in anatomic buttresses allow rehabilitation of atrophic maxillae in patients with combination syndrome. The implant success rate was high, and a mean marginal bone loss of 0.63 mm was recorded.

Side effects and complications of intraosseous anesthesia and conventional oral anesthesia.

OBJECTIVE: To analyze the side effects and complications following intraosseous anesthesia (IA), comparing them with those of the conventional oral anesthesia techniques. MATERIAL AND METHOD: A simple-blind, prospective clinical study was carried out. Each patient underwent two anesthetic techniques: conventional (local infiltration and locoregional anesthetic block) and intraosseous, for respective dental operations. In order to allow comparison of IA versus conventional anesthesia, the two operations were similar and affected the same two teeth in opposite quadrants. Heart rate was recorded in all cases before injection of the anesthetic solution and again 30 seconds after injection. The complications observed after anesthetic administration were recorded. RESULTS: A total of 200 oral anesthetic procedures were carried out in 100 patients. Both IA and conventional anesthesia resulted in a significant increase in heart rate, though the increase was greater with the latter technique. Incidents were infrequent with either anesthetic technique, with no significant differences between them. Regarding the complications, there were significant differences in pain at the injection site, with more intense pain in the case of IA (x2=3.532, p=0.030, Φ2=0.02), while the limitation of oral aperture was more pronounced with conventional anesthesia (x2=5.128, p<0.05, Φ2=0.014). Post-anesthetic biting showed no significant differences (x2=4.082, p=0.121, Φ2=0.009). CONCLUSIONS: Both anesthetic techniques significantly increased heart rate, and IA caused comparatively more pain at the injection site, while limited oral aperture was more frequent with conventional anesthesia. Post-anesthetic biting showed no significant differences between the two techniques.

Symptoms before periapical surgery related to histologic diagnosis and postoperative healing at 12 months for 178 periapical lesions.

PURPOSE: To compare the preoperative signs and symptoms with the histologic diagnosis and postoperative healing at 12 months for 178 periapical lesions. MATERIALS AND METHODS: A total of 152 patients who had undergone periapical surgery from 2005 to 2008 were studied. The study included patients presenting with signs and symptoms before periapical surgery with a sufficient tissue sample (periapical lesion) for histologic analysis and a minimal follow-up of 12 months. The signs and symptoms present in the soft tissues at the initial examination were recorded. The histologic analysis established the diagnosis as granuloma, cyst, or scar tissue. The postoperative healing at 12 months was evaluated according to the criteria of von Arx and Kurt. RESULTS: Of the 152 patients, 147, with 178 periapical lesions, were included in the present study. No significant relationship was found between the preoperative signs and symptoms, lesion type, and evolution. However, scar tissues were asymptomatic in 78.1%, and 36.4% of granulomas were painful. Of the 8 cysts, 50% were asymptomatic and 50% caused pain. Fibrous scars created no soft tissue alterations in 68.7%. Granulomas had fistulized in 31.7%, and 75% of cysts had produced no alterations. The lesions with swelling had worse healing, and those with no soft tissue alterations had better postoperative healing. CONCLUSIONS: Chronic periapical lesions (granuloma, cyst, and scar tissue) are usually asymptomatic and do not create soft tissue alterations. However, they can deteriorate, producing pain and fistulization. Worse postoperative healing was observed for lesions with swelling, although the difference was not significant.

Satisfaction of patients fitted with implant-retained overdentures.

OBJECTIVE: to evaluate patient satisfaction with implant-retained overdentures, and its relationship with age, sex, period of follow-up, the rehabilitated jaw (maxilla, mandible or both), number of implants, splinting, type of attachment and the antagonist. MATERIAL AND METHODS: the study comprised patients with overdentures fitted between January 1996 and June 2007, and with a minimum follow-up of one year. Data regarding patients and prostheses were collected. The patients indicated their overall satisfaction on a visual analogue scale (VAS) from 0 to 10, as well as satisfaction for individual items such as aesthetics, speech, mastication, prosthetic stability and self-esteem. These data were collected one month after fitting the prostheses, at 12 months and at a final examination. Statistical analyses were made using the SPSS version 15, statistical significance was considered for p<0.05. RESULTS: the study included 95 patients, 43 men and 52 women, with a mean age of 55.9 years; 76 edentulous mandibles and 31 edentulous maxillae were rehabilitated with 107 overdentures. One hundred and thirty-seven implants were placed in the maxilla, and 224 in the mandible. The mean level of overall satisfaction was 9 at one month of fitting the prosthesis, 8.8 at 12 months and 8.7 at the final control (mean 71 months). CONCLUSIONS: the patients fitted with implant-retained overdentures expressed a high level of overall satisfaction, independently of age, sex, length of follow-up, rehabilitated jaw, number of implants per overdenture, whether splinted or non-splinted, and type of attachment. Men were more satisfied with mastication and stability.

Identification of the Pathway and Appropriate Use of Four Zygomatic Implants in the Atrophic Maxilla: A Cross-Sectional Study.

PURPOSE: This cross-sectional study aimed to identify and characterize the pathway for appropriate placement of four zygomatic implants in the severely atrophic maxilla and to group the anatomical variations of the osteotomy trajectory for anterior zygomatic implants. MATERIALS AND METHODS: CBCT images of patients presenting indications for the use of four zygomatic implants to withstand a maxillary rehabilitation were reviewed. Cross-sectional planes corresponding to the implant trajectories, designed according to a zygoma anatomy-guided approach for implants placed in the anterior and posterior maxilla, were assessed separately. The relationship of the implant osteotomy trajectory with the correlated residual alveolar bone, nasal and sinus cavities, maxillary wall, and zygomatic bone anatomies was established. RESULTS: The study population included 122 globally recruited patients, with 488 zygomatic implants, 244 of which had their starting point on the anterior incisor-canine area and 244 on the posterior premolar-molar area. The anatomy of the osteotomy path designed for the anterior implants ("A") was named and grouped into five assemblies from zygomatic anatomy-guided ZAGA A-0 to A-4, representing 2.9%, 4.5%, 19.7%, 55.7%, and 17.2% of the studied sites. Percentages for posterior implant ("P") trajectories of the osteotomy were grouped and named as ZAGA P-0 to P-4, representing 5.7%, 10.2%, 8.2%, 18.4%, and 57.4% of the sites, respectively. Approximately 70% of the population presented anatomical intra-individual differences. CONCLUSION: The trajectory of the zygomatic implant followed different anatomical pathways depending on its coronal point being anteriorly or posteriorly located, which justifies a new zygoma anatomy-guided approach classification for anteriorly placed zygomatic implants. Topographic characteristics of the anatomical structures that are cut by an anterior oblique plane joining the lateral incisor-canine area to the zygomatic bone, representing the planned anterior osteotomy path in a quadruple-zygoma indication, have not been previously reported. Adaptation of surgical procedures and implant sections/designs to individual patients' anatomical characteristics is essential to reduce early and long-term complications.

Maximum use of the anterior maxillary buttress in severe maxillary atrophy with tilted, palatally positioned implants: a preliminary study.

PURPOSE: To evaluate an alternative treatment for rehabilitation of the atrophic maxilla with palatal and tilted implants and to assess patient satisfaction with the results. MATERIALS AND METHODS: A retrospective case study was made of completely edentulous subjects with tilted, palatally positioned implants in the anterior maxillary buttress placed and loaded between January 2005 and January 2007. Patients with severely resorbed edentulous maxillae (Class V according to Cawood and Howell) who requested overdentures and were followed for 12 months after implant loading were included. Mesial and distal implant bone loss was measured on panoramic radiographs. Subjects indicated satisfaction with the new prosthesis after 12 months on a visual analog scale. RESULTS: Twelve patients treated with tilted and palatal implants in the anterior maxillary buttress were included in the study; 48 implants were placed (4 implants in each patient) to support 12 overdentures with bars. One implant failed, resulting in a survival rate of 97.9%. The mean peri-implant bone loss of implants with palatal anchorage after 1 year of loading was 0.78 ± 0.5 mm. All patients had stable prostheses at the end of the observation period. Patients were satisfied with comfort and stability, ability to speak, ease of cleaning, esthetics, and function of the prosthesis. CONCLUSION: Placement of implants slightly to the palatal and tilted in the anterior maxillary buttress to support an overdenture with bars may be a viable treatment alternative for the rehabilitation of the atrophic maxilla, providing a high level of satisfaction with the prosthesis and reducing patient morbidity and costs.

Influence of oral hygiene and smoking on pain and swelling after surgical extraction of impacted mandibular third molars.

PURPOSE: To assess the pain and swelling during the first week after surgical extraction of impacted mandibular third molars and the relationship with oral hygiene and smoking before surgery and during the postoperative period. MATERIALS AND METHODS: A prospective study was performed on patients undergoing surgical extractions of impacted mandibular third molars. Pain was recorded on a visual analog scale from 1 to 10 and swelling on a 4-point descriptive scale at 2, 6, and 12 hours after surgery and daily during the first postoperative week. Oral hygiene and smoking before surgery and during the postoperative period were recorded. Statistical analysis was performed of all the variables. A P value less than .05 was considered statistically significant. RESULTS: A total of 50 patients (27 men and 23 women) with a mean age of 26.3 years (range 18 to 39) underwent surgical extraction of an impacted third molar. The maximum pain occurred during the first day and the maximum swelling at 24 hours after surgery. The patients with a lower brushing frequency before surgery reported greater pain. Likewise, the patients who smoked more after surgery experienced greater pain at 24 hours postoperatively. The hygiene after surgery and smoking before the surgical intervention had no statistically significant relationship to the occurrence of pain (P > .05). Swelling had no relationship with the variables studied (P > .05). CONCLUSIONS: Surgical extraction of an impacted third molar caused moderate pain and swelling during the first 24 hours after surgery. A lower brushing frequency before surgery and during the first postoperative week as well as smoking after surgery were related to greater pain scores.

Immunohistochemical study of Langerhans cells in periapical lesions: correlation with inflammatory cell infiltration and epithelial cell proliferation.

AIM: The aim of this study is to determine the presence and distribution of Langerhans cells in periapical lesions, and correlate this with inflammatory cell infiltration and epithelial cell proliferation. MATERIAL AND METHODS: Seventy chronic dental periradicular lesions, obtained during periapical surgery from 70 patients, were included in this study, including: 46 granulomas, 18 scar tissue and 6 periradicular cysts. Immunohistochemical staining was performed using the following markers: CD3 to analyze the inflammatory infiltrate, CD1a to determine the presence of Langerhans cells and Ki67 to analyze the epithelial cell proliferation. The CD1a immunostaining density was established following Cincura (2007) criteria, being classified ranging from intense (3), moderate (2), discrete (1) or no (0) immunostaining. CD3 and Ki67 staining was evaluated following the Liapatas et al. scale, as: 0) no cells stained; 1) weak stain or few cells stained (11-25%); 2) moderate staining or some cells stained (26-75%); 3) intense staining or many cells stained (more than 76%). RESULTS: Langerhans cells were found in 32.8% of the periapical lesions being more intense in the epithelialized lesions. CD3 immunohistochemical staining was found in all lesions, but with different values in relation to histological subtypes. Ki67 was positive in all epithelialized lesions, although with a moderate staining. CONCLUSIONS: Langerhans cells appeared to be associated with T-lymphocyte infiltration and the proliferative potential of the epithelial tissue in periapical lesions.

Immediate implants after the removal of maxillary impacted canines: a clinical series of nine patients.

PURPOSE: When impacted maxillary canines are not amenable to orthodontic traction or reimplantation, extraction is the only solution available, followed by the option of implant placement. The aim of this study was to present a surgical technique that allows placement of immediate implants following extraction of impacted maxillary canines. MATERIALS AND METHODS: Included in the study were patients with impacted maxillary canines who refused orthodontic treatment or transplantation and/or in whom the position of the canine teeth did not allow fenestration and orthodontic traction. The canines were removed, with the apical and ridge crest bone preserved to allow immediate implant placement anchored bicortically with good primary stability. The full circumference of the implants had no bone coverage except for the apical and coronal parts and were covered with bone shavings collected by the filter of the surgical aspirator during ostectomy. The definitive restorations were positioned after a healing period of 2 to 3 months. After 12 months, data were recorded relating to the clinical and radiographic condition of the implants. RESULTS: Ten impacted maxillary canines were extracted from nine patients (in one patient, both impacted maxillary canines were extracted) with a mean age of 40.3 years (range, 32 to 63 years), and 10 immediate implants were placed. All the implants had primary stability with a mean Osstell value of 61.5 on the day of surgery. At 12 months of follow-up, all the implants were considered to be successful. Digital periapical radiographs demonstrated a mean peri-implant bone loss of 0.49 mm (range, 0.15 to 1.1 mm). CONCLUSION: The removal of impacted canines followed by immediate implant placement minimizes the number of surgical interventions and the waiting time, although increased surgical skill is needed to place the implants.

Palatal positioning of implants in severely resorbed edentulous maxillae.

PURPOSE: The aim of this study was to evaluate implant-supported restorations supported by palatally positioned implants as an alternative treatment for rehabilitation of the atrophic maxilla and to assess the satisfaction of patients with the results. MATERIALS AND METHODS: A retrospective case study was conducted on completely edentulous subjects who received palatally positioned implants (placed and loaded) between January 2000 and January 2004. Inclusion criteria were patients with severely resorbed edentulous maxillae (Class IV or V maxillary atrophy, according to the Cawood and Howell classification) who requested implant-supported restorations and had a follow-up period of at least 24 months after implant loading. Panoramic radiographs and maxillary computerized tomograms had been made for all patients prior to treatment. Mesial and distal implant bone loss was measured on panoramic radiographs, and the largest value was designated as the bone loss for the implant in question. Subjects indicated their degree of satisfaction with the new prosthesis after 12 months on a visual analogue scale. RESULTS: Sixty-nine patients with severely resorbed edentulous maxillae were included in the study. Four hundred and ninety implants (six to eight in each patient) were placed to support 69 fixed prostheses; 330 were in palatal positions and 160 were in molar positions (84 over the crest in the first molar position and 76 in anatomic buttresses). The success rate of palatally positioned implants was 97.8% (323/330). The mean bone loss of implants with palatal anchorage after 2 years of loading was 0.61 mm (range, 0 to 3.10 mm). All patients had stable prostheses at the end of the observation period. Patients were satisfied with comfort and stability, ability to speak, ease of cleaning, esthetics, and function of the prosthesis. CONCLUSION: Implants placed in a palatal position may be a viable alternative for rehabilitation of the atrophied maxilla.

The nasopalatine canal as an anatomic buttress for implant placement in the severely atrophic maxilla: a pilot study.

PURPOSE: The aim of this study was to present an alternative treatment concept for the rehabilitation of the atrophic maxilla that used the nasopalatine canal as an anatomic buttress for dental implant insertion and to assess patient satisfaction with this treatment. MATERIALS AND METHODS: The inclusion criterion for the study consisted of the presence of severe resorption of the edentulous maxilla (Class V according to the Cawood and Howell classification). In each patient, one implant was positioned in the nasopalatine canal. Additional implants were also placed in the remaining maxillary bone. The patients were followed for a minimum of 2 years after prosthesis connection. Satisfaction with the prosthesis was evaluated after 12 months using a visual analog scale. RESULTS: Seven patients with severely resorbed edentulous maxillae received a total of seven implants in the nasopalatine buttress and 29 implants posterior to this structure. One of the seven implants in the nasopalatine canal was lost during the osseointegration phase. All patients had stable prostheses at the end of the observation period. Patients were satisfied with comfort and stability, ability to speak, ease of cleaning, and esthetics and function of the prosthesis. Five patients experienced minor sensory alterations during the first weeks after surgery. At the final examination, which took place after a mean of 5 years (range, 3 to 7 years), all patients expressed the presence of normal sensation. CONCLUSIONS: It appears that implants in the nasopalatine canal may be a viable treatment approach for the rehabilitation of the severely atrophied maxilla. Patients were satisfied with a prosthesis supported by implants in the nasopalatine canal.

Retrospective study of 68 implants placed in the pterygomaxillary region using drills and osteotomes.

PURPOSE: The aim of this study was to evaluate the success rate of implants placed in the pterygomaxillary region using drills and osteotomes with a minimum of 12 months' follow-up. Bone loss after 1 year of loading and patient satisfaction with the prosthesis were evaluated. MATERIAL AND METHODS: A retrospective case study was made. The sample was composed of patients rehabilitated with pterygoid implants between January 2000 and January 2006. The inclusion criteria were patients in good general health with severe atrophy of the posterior maxilla who had been rehabilitated with one or two pterygoid implants inserted using drills and osteotomes and had been followed for 12 months after implant loading. Implant success was defined according to the criteria of Albrektsson et al. Bone loss was measured on panoramic radiographs on the mesial and distal of each implant, and the largest value (whether mesial or distal) was selected as the bone loss for the implant in question. Subjects indicated satisfaction with the new prosthesis on a visual analogue scale. RESULTS: Forty-five patients were treated with 268 implants (200 anterior and 68 pterygoid). The success rate of pterygoid implants was 97.05%. The mean bone loss around implants in the pterygomaxillary region after 1 year of loading was 0.71 mm (range, 0 to 3.20). All prostheses were stable at the end of the observation period. Patients were satisfied with comfort and stability, ability to speak, ease of cleaning, and esthetics and functionality of the prosthesis. CONCLUSION: Placement of implants in the posterior pterygomaxillary region using drills and osteotomes is a viable alternative treatment modality for rehabilitation of atrophic posterior maxilla. Patients were satisfied with a prosthesis supported by pterygoid implants.

Immediate loading of immediate mandibular implants with a full-arch fixed prosthesis: a preliminary study.

PURPOSE: To determine the survival of immediate dental implants with immediate loading in the partially edentulous mandible, by use of a full-arch screw-retained provisional restoration. MATERIALS AND METHODS: Patients who were partially edentulous in the mandible with indications for extraction of the remaining teeth and with a minimum follow-up of 12 months after implant placement were included in the study. They were treated in chronologic order by the insertion of 6 Defcon dental implants (Impladent, Sentmenat, Spain) subjected to immediate loading (4 interforaminal and 2 posterior placements). Implants with a minimum primary stability of 60 implant stability quotient were loaded. All resin screw-retained prostheses were inserted and loaded with fully functional occlusion within 24 hours of implant placement. RESULTS: Eleven patients were treated with immediate implants, although 2 patients were excluded from the study for having an implant stability quotient value below 60 in at least one of the implants after surgery and did not undergo restoration with immediate loading. Fifty-four implants were placed in 9 partially edentulous patients with immediate loading with a full-arch screw-fixed prosthesis. The patients wore this provisional prosthesis during the healing period (2 months) without complication and with a high level of comfort. The survival rate of the implants was 100% at 12 months of follow-up. CONCLUSION: Immediate mandibular loading with immediate full-arch implant-supported and screw-retained restorations is a viable treatment alternative, yielding a 100% success rate in this small series of patients.

Idiopathic trigeminal neuropathies: a presentation of 15 cases.

PURPOSE: The aim of this study is to present a clinical series of patients with trigeminal neuropathy and their treatment. PATIENTS AND METHODS: We present a retrospective study of 15 cases of idiopathic trigeminal neuropathies, with unilateral involvement of 1 or more divisions of the trigeminal nerve. The clinical, radiologic, and laboratory data of the patients, in addition to the treatment and clinical evolution, were reviewed. The patients were followed up for a mean of 34.4 months (range, 12-120 months). RESULTS: The study consisted of 11 women and 4 men. The numbness was predominantly located in the innervated mental area and extended in some cases to the first and second trigeminal divisions. Seven patients had slight continuous discomfort in association with the numbness, one of whom had added bouts of typical neurogenic pain. Of the 15 cases, 8 (53%) had acute idiopathic trigeminal neuropathies and fully recovered within 3 months and 7 (47%) were chronic cases, without full recovery after 3 months. Mild pain was felt by 57% of the chronic patients and 37% of the acute patients; treatment with amitriptyline achieved complete or partial improvement in over half of these patients. CONCLUSION: Of the idiopathic trigeminal neuropathies, half were acute and half were chronic. Mild pain presented more frequently in the chronic patients and was relieved with amitriptyline.

Metal Nanoparticles Released from Dental Implant Surfaces: Potential Contribution to Chronic Inflammation and Peri-Implant Bone Loss.

Peri-implantitis is an inflammatory disease affecting tissues surrounding dental implants. Although it represents a common complication of dental implant treatments, the underlying mechanisms have not yet been fully described. The aim of this study is to identify the role of titanium nanoparticles released form the implants on the chronic inflammation and bone lysis in the surrounding tissue. We analyzed the in vitro effect of titanium (Ti) particle exposure on mesenchymal stem cells (MSCs) and fibroblasts (FU), evaluating cell proliferation by MTT test and the generation of reactive oxygen species (ROS). Subsequently, in vivo analysis of peri-implant Ti particle distribution, histological, and molecular analyses were performed. Ti particles led to a time-dependent decrease in cell viability and increase in ROS production in both MSCs and FU. Tissue analyses revealed presence of oxidative stress, high extracellular and intracellular Ti levels and imbalanced bone turnover. High expression of ZFP467 and the presence of adipose-like tissue suggested dysregulation of the MSC population; alterations in vessel morphology were identified. The results suggest that Ti particles may induce the production of high ROS levels, recruiting abnormal quantity of neutrophils able to produce high level of metalloproteinase. This induces the degradation of collagen fibers. These events may influence MSC commitment, with an imbalance of bone regeneration.