Intravenous thrombolysis in acute ischemic stroke after POLKARD: one center analysis of program impact on clinical practice.

PURPOSE: Intravenous thrombolysis in the acute ischemic stroke was initiated in Poland within the National Cardiovascular Disease Prevention and Treatment Program POLKARD in the years 2003-2008. Since 2009 the procedure has been reimbursed by the National Health Fund (Narodowy Fundusz Zdrowia - NFZ). The purpose of the presented study was to assess whether the change of financing institution was associated with the change in proportion of patients treated and with any of the clinical parameters or stroke outcomes. PATIENTS AND METHODS: We reviewed the data of the 90 consecutive patients with acute ischemic stroke treated with intravenous thrombolysis within 3-hours from symptoms onset. The differences between the POLKARD period and the year 2009, regarding clinical parameters, time delays, death rates and functional outcomes on day 90 after the stroke were analyzed. The association of outcome measures with baseline characteristics of the patients was analyzed with binary logistic regression. RESULTS: In 2009 there was a significant increase in the proportion of patients treated (7.6%, 95%CI 5.3-10.7%, vs. 4.3%, 95%CI 3.3-5.5% respectively, p=0.013). There were no differences in age, baseline neurological presentation, prevalence of stoke risk factors, treatment time delays or hemorrhagic complications. Higher, but not significantly, 90-day mortality was observed (32.1%, 95%CI 13.3-54.1% vs. 16.1%, 95%CI 6.4-29.7% respectively, p=0.101). Baseline neurological deficits and in-hospital treatment time delays were significant predictors of disability and death. CONCLUSIONS: After the Polish Ministry of Health program POLKARD termination and elimination of the reimbursement limits, higher proportion of ischemic stroke patients could be treated with the intravenous thrombolysis.

[Personal studies of threshold values in planimetric measurements of pulmonary pressure]. / Wlasne badania nad wartoscia progowa w planimetrycznym oznaczaniu cisnienia w tetnicy plucnej.

Assessment of the pulmonary pressure is of importance in cardiopulmonary diseases, the most exact data are achieved with direct measurements. However, this invasive technique, which is rarely available. Therefore, the authors have elaborated the radiological technique of pulmonary pressure assessment, based on chest X-rays. Eighty patients were examined radiologically, and pulmonary pressure was evaluated planimetrically by measurements of the intermediate artery and both arteries of the anterior upper segments diameters on X-ray. These results were compared with the measurements obtained with microcatheterization technique. The authors recommend planimetric measurements for usual practice and screening of larger number of patients.