1.
AIDS
; 38(11): 1725-1727, 2024 Sep 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-39088830
RESUMEN
We explored the impact of immune dysregulation on pancreatic beta cell injury in HIV patients. Analyzing 105 participant samples, we observed lower IL-21 levels and elevated immune checkpoint levels (e.g. PD-1, CD27+, CD40+) in untreated HIV patients. Notably, soluble TIM-3 correlated positively with improved beta cell function and inversely with beta cell stress, suggesting its potential role in beta cell protection in untreated HIV.