Environmental concerns and bioaccumulation of psychiatric drugs in water bodies - Conventional versus biocatalytic systems of mitigation.

The COVID-19 pandemic has brought increments in market sales and prescription of medicines commonly used to treat mental health disorders, such as depression, anxiety, stress, and related problems. The increasing use of these drugs, named psychiatric drugs, has led to their persistence in aquatic systems (bioaccumulation), since they are recalcitrant to conventional physical and chemical treatments typically used in wastewater treatment plants. An emerging environmental concern caused by the bioaccumulation of psychiatric drugs has been attributed to the potential ecological and toxicological risk that these medicines might have over human health, animals, and plants. Thus, by the application of biocatalysis-assisted techniques, it is possible to efficiently remove psychiatric drugs from water. Biocatalysis, is a widely employed and highly efficient process implemented in the biotransformation of a wide range of contaminants, since it has important differences in terms of catalytic behavior, compared to common treatment techniques, including photodegradation, Fenton, and thermal treatments, among others. Moreover, it is noticed the importance to monitor transformation products of degradation and biodegradation, since according to the applied removal technique, different toxic transformation products have been reported to appear after the application of physical and chemical procedures. In addition, this work deals with the discussion of differences existing between high- and low-income countries, according to their environmental regulations regarding waste management policies, especially waste of the drug industry.

Recent Advances in Prodigiosin as a Bioactive Compound in Nanocomposite Applications.

Bionanocomposites based on natural bioactive entities have gained importance due to their abundance; renewable and environmentally benign nature; and outstanding properties with applied perspective. Additionally, their formulation with biological molecules with antimicrobial, antioxidant, and anticancer activities has been produced nowadays. The present review details the state of the art and the importance of this pyrrolic compound produced by microorganisms, with interest towards Serratia marcescens, including production strategies at a laboratory level and scale-up to bioreactors. Promising results of its biological activity have been reported to date, and the advances and applications in bionanocomposites are the most recent strategy to potentiate and to obtain new carriers for the transport and controlled release of prodigiosin. Prodigiosin, a bioactive secondary metabolite, produced by Serratia marcescens, is an effective proapoptotic agent against bacterial and fungal strains as well as cancer cell lines. Furthermore, this molecule presents antioxidant activity, which makes it ideal for treating wounds and promoting the general improvement of the immune system. Likewise, some of the characteristics of prodigiosin, such as hydrophobicity, limit its use for medical and biotechnological applications; however, this can be overcome by using it as a component of a bionanocomposite. This review focuses on the chemistry and the structure of the bionanocomposites currently developed using biorenewable resources. Moreover, the work illuminates recent developments in pyrrole-based bionanocomposites, with special insight to its application in the medical area.

Towards a Combined Use of Geophysics and Remote Sensing Techniques for the Characterization of a Singular Building: "El Torreón" (the Tower) at Ulaca Oppidum (Solosancho, Ávila, Spain).

This research focuses on the study of the ruins of a large building known as "El Torreón" (the Tower), belonging to the Ulaca oppidum (Solosancho, Province of Ávila, Spain). Different remote sensing and geophysical approaches have been used to fulfil this objective, providing a better understanding of the building's functionality in this town, which belongs to the Late Iron Age (ca. 300-50 BCE). In this sense, the outer limits of the ruins have been identified using photogrammetry and convergent drone flights. An additional drone flight was conducted in the surrounding area to find additional data that could be used for more global interpretations. Magnetometry was used to analyze the underground bedrock structure and ground penetrating radar (GPR) was employed to evaluate the internal layout of the ruins. The combination of these digital methodologies (surface and underground) has provided a new perspective for the improved interpretation of "El Torreón" and its characteristics. Research of this type presents additional guidelines for better understanding of the role of this structure with regards to other buildings in the Ulaca oppidum. The results of these studies will additionally allow archaeologists to better plan future interventions while presenting new data that can be used for the interpretation of this archaeological complex on a larger scale.

Nanomaterial Constructs for Catalytic Applications in Biomedicine: Nanobiocatalysts and Nanozymes.

Nanomaterials possess superior advantages due to their special geometries, higher surface area, and unique mechanical, optical, and physicochemical properties. Their characteristics make them great contributors to the development of many technological and industrial sectors. Therefore, novel nanomaterials have an increasing interest in many research areas including biomedicine such as chronic inflammations, disease detection, drug delivery, and infections treatment. Their relevant role is, in many cases, associated with an effective catalytic application, either as a pure catalyst (acting as a nanozyme) or as a support for catalytically active materials (forming nanobiocatalysts). In this review, we analyze the construction of nanozymes and nanobiocatalyst by different existing forms of nanomaterials including carbon-based nanomaterials, metal-based nanomaterials, and polymer-based nanocomposites. Then, we examine successful examples of such nanomaterials employed in biomedical research. The role played by nanomaterials in catalytic applications is analyzed to identify possible research directions toward the development of the field and the achievement of real practicability.

Prospecting carbon-based nanomaterials for the treatment and degradation of endocrine-disrupting pollutants.

The presence of endocrine-disrupting chemicals (EDCs) in water resources has significant negative implications for the environment. Traditional technologies implemented for water treatment are not completely efficient for removing EDCs from water. Therefore, research on sustainable remediation has been mainly directed to novel decontamination approaches including nano-remediation. This emerging technology employs engineered nanomaterials to clean up the environment quickly, efficiently, and sustainably. Thus, nanomaterials have contributed to a wide variety of remediation techniques like adsorption, filtration, coagulation/flocculation, and so on. Among the vast diversity of decontamination technologies catalytic advanced oxidation processes (AOPs) outstand as simple, clean, and efficient alternatives. A vast diversity of catalysts has been developed demonstrating high efficiencies; however, the search for novel catalysts with enhanced performances continues. In this regard, nanomaterials used as nanocatalysts are exhibiting enhanced performances on AOPs due to their special nanostructures and larger specific surface areas. Therefore, in this review we summarize, compare, and discuss the recent advances on nanocatalysts, catalysts doped with metal-based nanomaterials, and catalysts doped with carbon-based nanomaterials on the degradation of EDCs. Finally, further research opportunities are identified and discussed to achieve the real application of nanomaterials to efficiently degrade EDCs from water resources.