Neurotrophic Keratitis in a Pediatric Patient With Goldenhar Syndrome and Trigeminal Aplasia Successfully Treated by Corneal Neurotization.

Herein, the authors report an unusual case of a 6-year-old boy with right-sided Goldenhar syndrome and trigeminal nerve aplasia who developed neurotrophic keratopathy (NK). Despite the use of therapeutic contact lenses and multiple temporary tarsorrhaphy, NK worsened showing a central corneal scar, neovascularization, and significant stromal thinning, with risk of corneal perforation. Cochet-Bonnet esthesiometry revealed complete corneal anesthesia. To minimize additional corneal complications, the patient underwent indirect corneal neurotization by a sural nerve autograft anastomosed to the contralateral supratrochlear nerve. At 24-month follow up, no epithelial defects, complications, or recurrence were observed. Significant improvements in corneal sensitivity with esthesiometry score of 20 mm and reflex blinking were achieved. This case highlights corneal anesthesia should be suspected among Goldenhar syndrome ophthalmologic abnormalities and monitored before corneal changes become irreversible. Since corneal neurotization can successfully improve corneal sensation, it could be considered as an early therapeutic option to avoid refractory NK.

Oral florid papillomatosis: Topical treatment with 5% imiquimod in orabase.

BACKGROUND: Florid oral papillomatosis is characterized by its tendency to local recurrence that requires multiple treatments, leading to important functional sequelae. METHODS: We present 74-year-old woman with oral florid papillomatosis (OFP) who refused a new surgical treatment, and was treated with imiquimod 5% in orabase on alternate days for 16 weeks. Treatment was complemented with application of hyaluronic acid gel. RESULTS: There were no side effects to the treatment, nor signs of local recurrence, in the treated area at 2 years of follow-up. CONCLUSIONS: After reviewing the literature and according to our knowledge, this is the first published case of oral florid papillomatosis treated topically with imiquimod 5% successfully. Topical treatment with imiquimod 5% in orabase may be a valid alternative for patients with recurrent OFP located in the anterior area of the oral cavity who refuse surgical treatment, although we must closely monitor the patient for the possibility of recurrence or malignant degeneration.

[Minimal important clinical difference in health-related quality of life.] / Diferencia mínima clínica importante en calidad de vida relacionada con la salud.

Una de las limitaciones para el uso de los Cuestionarios de Calidad de Vida Relacionada con la Salud y de los resultados reportados por pacientes es la dificultad de interpretar los valores obtenidos. La diferencia mínima clínica importante es una medida que ayuda a comprender los resultados de estos cuestionarios y valorar la relevancia clínica del efecto conseguido por la intervención realizada. En este trabajo revisamos el concepto de diferencia mínima clínica importante, describimos los métodos utilizados para su obtención y exponemos sus dificultades, limitaciones y aplicabilidad. Dentro de los resultados reportados por pacientes y, particularmente, en los de calidad de vida, la diferencia mínima clínica importante es una herramienta que ayuda a los clínicos a utilizar correctamente las escalas de medida e interpretar el efecto de las intervenciones. Con este artículo esperamos facilitar la implantación y uso de la diferencia mínima clínica importante y los Cuestionarios de Calidad de Vida Relacionada con la Salud en la práctica habitual con nuestros pacientes.

One of the limitations for the use of Health-related Quality of Life Questionnaires and the results reported by patients is the difficulty of interpreting the values obtained. The minimal important clinical difference is a measure that helps to understand the results of these questionnaires and assess the clinical relevance of the effect achieved by the intervention performed. In this paper, we review the concept of minimal important clinical difference, describe the methods used to obtain it, and expose its difficulties, limitations, and applicability. Within the results reported by patients, and particularly in quality of life, the minimal important clinical difference is a tool that helps clinicians to correctly use the measurement scales and interpret the effect of the interventions. With this article, we hope to facilitate the implementation and use of the minimal important clinical difference and the Health-related Quality of Life Questionnaires in routine practice with our patients.

Synchronous occurrence of IgG4-related sialadenitis and ductal carcinoma of the parotid gland: a case report.

Immunoglobulin G4-related disease (IgG4-RD) is a rare chronic systemic inflammatory pathology that poses a diagnostic challenge since it can simulate malignancy when it affects a salivary gland as a mass-like lesion. Here, the authors report an unusual clinical case of a 42-year-old man who presented with a painless, slow-growing swelling located in the right parotid gland with a 12-month evolution. Based on imaging tests and open biopsy, a diagnosis of chronic parotitis was presumed and oral methylprednisolone was prescribed. Due to poor response to medication, a total parotidectomy preserving the facial nerve was performed. The final pathology described a unilateral IgG4-related sialadenitis (IgG4-RS) in the parotid gland in combination with a poorly differentiated multifocal ductal carcinoma. The postoperative course was uneventful except for a temporary facial paresis (grade III according to the House-Brackmann classification system) that resolved completely within 5 months. There were no systemic manifestations on the whole-body 18F-FDG PET/CT. Adjuvant radiotherapy was administered without complications. Twenty-four months follow-up after surgery showed no recurrence or evidence of systemic involvement. This clinical report highlights the importance of considering the synchronous occurrence of a carcinoma underlying an isolated parotid gland mass in the context of IgG4-RS, especially if there is no response to prior steroid medication.

Quality of life in long-term oral cancer survivors: a comparison with Spanish general population norms.

PURPOSE: Health-related quality-of-life (HRQOL) data are becoming an important supplement to information pertaining to treatment outcomes for cancer patients. The purpose of this study was to evaluate the HRQOL of patients undergoing primary surgery for oral squamous cell carcinoma > or =5 years after treatment compared with the Spanish general population norms. MATERIALS AND METHODS: A total of 50 oral cancer patients (mean age 55.78 years, 80% male) with cancer-free survival of > or =5 years after surgery were enrolled. HRQOL was assessed with a standardized questionnaire: the Medical Outcomes Study Short Form 36-Item Health Survey. RESULTS: The Medical Outcomes Study Short Form 36-Item Health Survey scores of the oral cancer patients did not differ significantly from those of an age- and gender-matched sample from the Spanish normative population, except for the pain and social functioning domains. The patients had significantly better results compared with the population norms (Wilcoxon test, P < .05) in the physical function, general health, and vitality domains. CONCLUSIONS: These results provide patient-reported evidence that oral cancer survivors have a similar HRQOL compared with the general Spanish population. We also believe that it would be necessary to analyze the quality of life > or =5 years after treatment or from the moment the patient was discharged.

Modificaciones en el diseño de los implantes subperiósticos personalizados para evitar complicaciones. Presentación de una serie de casos y revisión de la literatura / Design modifications in subperiosteal implants to avoid complications. Presentation of a case series study and literature review

Introducción: La reabsorción severa del maxilar en pacientes totalmente edéntulos en ocasiones imposibilita la colocación de implantes endoóseos estándares para rehabilitar la ausencia de dientes. Para este tipo de atrofias tan severas se patentaron en 1938 en Suecia los implantes subperiósticos. Este tipo de implantes subperiósticos personalizados (ISP) han tenido excelentes resultados a lo largo de estos últimos años pero no están exentos de complicaciones. El objetivo de nuestro estudio es describir las principales complicaciones con este tipo de implantes y cuáles han sido las modificaciones que hemos realizado en el diseño de los mismos para intentar evitarlas.Material y método: Diseñamos un estudio de seguimiento retrospectivo de 15 pacientes con atrofia severa del maxilar superior tratados en 2 centros privados con un ISP en los años 2021 y 2022. Resultados: Los 8 primeros pacientes fueron tratados con un ISP bilateral y los 7 restantes con dos ISP uno a cada lado del maxilar. Todos los pacientes fueron rehabilitados con una prótesis provisional atornillada a las 48 horas de la cirugía y sustituida a los 3 meses por una prótesis fija definitiva. En 5 pacientes (33,33 %) tuvimos complicaciones postoperatorias menores. Conclusiones: A pesar de las limitaciones del estudio consideramos que el uso de ISP en pacientes con atrofia severa del maxilar es un tratamiento predecible y con excelentes resultados. La exposición es la principal complicación en nuestra serie de casos y consideramos que el uso de ISP dobles individuales y de una guía de corte minimizan el riesgo de que aparezca. (AU)

Introduction: Severe resorption of the maxilla in fully edentulous patients sometimes makes it impossible to place standard endoosseous implants to rehabilitate the absence of teeth. For such severe atrophies subperiosteal implants were patented in 1938 in Sweden. This type of subperiosteal implants have had excellent results over the last few years but are not without complications. The aim of our study is to describe the main complications with this type of implants and witch modifications have been made trying to avoid them. Material and method: We designed a retrospective follow-up study of 15 patients with severe upper jaw atrophy treated in 2 private centers with a customized subperiosteal implant in 2021 and 2022, to which we apply a few modifications in the design of the same. Results: First eight patients were treated with a single bilateral subperiosteal implant and the remaining seven with two subperiosteal implants, one on each side of the maxilla. All patients were treated with a temporary prosthesis bolted 48 hours after surgery and replaced at three months with a definitive prosthesis. In five patients (33.33%), we had minor postoperative complications. Conclusions: Despite the limitations of the study, we think that the use of customized subperiosteal implants in patients with severe maxillary atrophy is a predictable treatment with excellent results. Exposure is the main complication in our case series and we consider that the use of individual double subperiosteal implant and a bone cutting guide help to minimize the risk of this complication. (AU)

Preoperative ultrasonography for evaluation of clinically N0 neck in oral cavity carcinoma.

The aim of this study was to evaluate preoperative ultrasound criteria to detect lymph node (LN) cervical metastasis in patients with clinically node-negative neck (cN0) oral cavity squamous cell carcinoma (OCSCC). A prospective, single-center, observational study was conducted in 90 patients undergoing cancer excision with or without elective neck dissection (END) between 2005 and 2012. A surgeon and an experienced radiologist performed preoperative cervical ultrasonography in all cases. The primary objective was to obtain an a priori sensitivity of 90% and specificity >50% in cN0 OCSCC staging. The sonographic criteria for LN assessment were as follows: number; neck levels; clusters; aspect; heterogeneity; longitudinal diameter (L); transverse diameter (T); L/T ratio; and combination in series or in parallel of T and L/T ratio. The gold standard for comparison was the LN histological identification of metastasis after END or the occurrence in the follow-up at least 36 months. Statistically significant sonographic criteria in univariate analysis (P < 0.05) were as follows: multilevel lymph nodes, T diameter >6.5 mm, and the combination T > 6.5 mm or L/T < 1.3 ratio; and in multivariate logistic regression analysis were (P < 0.05): combination T > 6.5 mm and L/T < 1.3 ratio, LN in level II, and moderately-poorly differentiated OCSCC. By using selected sonographic criteria, ultrasound can be a valid preoperative diagnostic method to optimize staging cervical metastasis and to help decide about neck dissection.

Impact of the coronavirus pandemic on maxillofacial trauma: A retrospective study in southern Spain

Background: The coronavirus pandemic has impacted health systems worldwide, with Spain being one of the most affected countries. However, little is known about the extent to which the effects of staying home, social distancing, and quarantine measures have influenced the epidemiology of patients with maxillofacial trauma. The aim of this study was to analyze the impact of the coronavirus pandemic on the incidence, demographic patterns, and characteristics of maxillofacial fractures in the largest hospital in southern Spain. Material and Methods: Data from patients who underwent surgery for maxillofacial fractures during the first year of the pandemic between 16 March 2020 and 14 March 2021 (pandemic group) were retrospectively compared with a control group during the equivalent period of the previous year (pre-pandemic group). The incidence was compared by weeks and by lockdown periods of the population. Demographic information, aetioloy, fracture characteristics, treatment performed, and days of preoperative stay were evaluated. Descriptive and bivariate statistics were calculated (p<0.05). Results: During the first year of the pandemic, there was a 35.2% reduction in maxillofacial fractures (n=59) compared to the pre-pandemic year (n=91, p=0.040). A significant drop was detected during the total home lockdown period of the population (p=0.028). In the pandemic group, there was a reduction in fractures due to interpersonal aggressions, an increase in panfacial fractures, a significant increase in other non-facial injuries associated with polytrauma (p=0.037), a higher number of open reduction procedures with internal fixation, and a significantly longer mean preoperative stay (p=0.016). Conclusions: The first pandemic year was associated with a decline in the frequency of maxillofacial trauma and a change in the pattern and characteristics of fractures. Inter-annual epidemiological knowledge of maxillofacial fractures may be useful for more efficient planning of resource allocation and surgical practice strategy during future coronavirus outbreaks and population lockdowns.(AU)

Oral health-related quality of life after dental treatment in patients with intellectual disability

BACKGROUND: The influence of dental treatment on oral health-related quality of life (OHRQOL) has rarely been evaluated in patients with intellectual disability (ID) through validated questionnaires. The aim of this study was to estimate the changes on OHRQOL in patients with ID after the implementation of an institutional dental treatment program under general anesthesia using the Franciscan Hospital for Children Oral Health-Related Quality of Life questionnaire (FHCOHRQOL-Q). MATERIAL AND METHODS: A prospective longitudinal study was conducted on 85 patients (mean age=24.85 years) classified according to DSM-V whose parents/caregivers completed the FHC-OHRQOL-Q. We analyzed the changes in the questionnaire's overall score and its dimensions from pre-treatment to 12-months of follow-up, considering effect sizes and minimal important differences estimated by the standard measurement error. The impact of clinical and therapeutic factors was evaluated using univariate and multiple linear regression analysis (p < 0.05). RESULTS: Significant improvement of OHRQOL was found after dental treatment in oral symptoms (p ≤ 0.001), daily life problems (p = 0.018), parent's perceptions (p = 0.013) and FHCOHRQOL-Q's overall score (p = 0.001). OHRQOL changes exhibited an intermediate magnitude (0.38-0.21) as estimated by effect sizes. Changes in oral symptoms showed positive correlation with DMFT index (r = 0.375, p = 0.002), decayed teeth (r = 0.244, p = 0.036), dental extractions (r = 0.424, p < 0.001) and number of treatments (r = 0.255, p = 0.019). The improvement was greater in patients with ≥ 4 decayed teeth (p = 0.049) and undergoing ≥ 2 dental extractions (p = 0.002). Multiple regression analysis demonstrated that dental extractions (p < 0.001) and DMFT index ( p= 0.028) were significantly related to oral symptom improvement. CONCLUSIONS: Dental treatment under general anesthesia showed a positive effect on the overall FHC-OHRQOL-Q score and most of its dimensions. At 12-months of follow-up, the improvement of oral symptoms was significantly associated with DMFT index, decayed teeth, dental extractions and number of treatments. In our clinical setting, the implementation of a dental treatment program enhanced the OHRQOL of patients with ID

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Validation of the Spanish version of the Franciscan Hospital for Children Oral Health-Related Quality of Life questionnaire

BACKGROUND: The Franciscan Hospital for Children Oral Health-Related Quality of Life questionnaire (FHC-OHRQOL-Q) is an instrument designed specifically for parents and caregivers of patients with special needs that has not yet been applied in Spain. The aim of this study was to adapt it to Spanish and evaluate its reliability and validity in patients with intellectual disability (ID) treated under general anesthesia. MATERIAL AND METHODS: The study was conducted in two different stages: a) cross-cultural adaptation of the original questionnaire, and b) cross-sectional study on 100 parents and caregivers who completed the piloted FHC-OHRQOL-Q. The patients were examined according to the WHO methodology. Dental treatments performed were recorded. Statistical tests were used to evaluate reliability (internal consistency) and validity (content, criterion, construct and discriminant) of the instrument. RESULTS: The mean age was 24 years (range = 4-71 years). The most frequent causes of ID were psychomotor retardation (25%) and cerebral palsy (24%). The items most frequently answered by parents and caregivers were eating and nutrition problems (80%) and bad breath/taste (57%). Reliability (Cronbach's alpha coefficient) was considered excellent (alpha = 0.80-0.95). The analysis of the factorial validity yielded similar results to the original questionnaire. The high response rate of items (> 96%) allowed content validity. Criterion validity was confirmed by a significant correlation with questions on oral health and oral well-being. Discriminant validity was demonstrated by the significant association of ≥ 21.5 years of age with worse oral symptoms (p = 0.034) and parental concerns (p = 0.005), DMFT index ≥ 3 with daily life problems (p = 0.02), ≥ 4 decayed teeth with daily life problems (p = 0,001= daily life problems (p = 0.002) and parent ́s perceptions (p = 0.043). CONCLUSIONS: The FHC-OHRQOL-Q in Spanish is a reliable and valid instrument to apply in clinical practice to evaluate the impact of OHRQOL in mostly adult patients with ID, accessible to Spanish-speaking parents and caregivers

Assessment of pre and postoperative anxiety in patients undergoing ambulatory oral surgery in primary care

Background: To analyze the pre- and postoperative anxiety level in patients undergoing ambulatory oral surgery (AOS) in a primary healthcare center (PHC). Material and Methods: Prospective and descriptive clinical study on 45 patients who underwent AOS procedures in the dental clinic of a public PHC of Spain between April and September 2015. Anxiety analysis was carried out with pre- and postoperative anxiety-state (STAI-S), anxiety-trait (STAI-T) and dental anxiety (MDAS) questionnaires. A descriptive, inferential and binary logistic regression analysis were performed for the variables age, sex, educational level, previous experience of oral treatment, type of oral surgery, degree of third molar impaction, surgical time, intraoperative complications, postoperative complications, and pain score with a visual analogue scale (VAS). Results: The majority were female (57.8%) with a mean age of 33.5±9.6 years. The most frequent procedure was the lower third molar removal (82.2%). The mean pain score on the VAS was 1.6±1.8. The incidence of complications was low (7.8%). There was a statistically significant association between post- and preoperative anxiety (r=0.56, p<0.001) and a correlation between pain score and postoperative anxiety (Rho= -0.35, p=0.02). The likelihood of postoperative anxiety was related to preoperative anxiety (OR=1.3, p=0.03). Conclusions: AOS in a PHC is safe and should be more encouraged in the public primary care. The emotional impact on users was relatively low, highlighting that the preoperative anxiety levels were higher than the postoperative ones. Psychological factors related to pre- and postoperative anxiety should be considered in the AOS carried out in PC (AU)

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W43X SDHD mutation in sporadic head and neck paraganglioma.

OBJECTIVE: To analyze the presence of SDHD gene mutations in patients with sporadic head and neck paraganglioma. STUDY DESIGN: The presence of somatic and germline SDHD mutations was investigated in 10 patients by polymerase chain reaction and direct sequencing. RESULTS: Two patients displayed mutations: 259C>T (P87S) in 1 case and 129G>A (W43X) in the other. The first was considered a neutral polymorphism. The second was present in the germline of 1 of her sons, who had an apparently unrelated testicular seminoma and loss of heterozygosity (LOH) in the tumor cells. CONCLUSION: This is the first reported case of an SDHD mutation carrier showing LOH in a testicular seminoma.

Modelo y cumplimentacion de alta hospitalaria de la unidad de gestión clínica de cirugía oral y maxilofacial. Cómo mejorarlo / Filling in the hospital discharge report in an oral and maxillofacial surgery clinical management unit. how to improve it

Objetivos. Conocer la calidad y grado de cumplimentación de la información recogida en las altas hospitalarias (IAH) del Servicio de Cirugía Oral y Maxilofacial de nuestro hospital. Material y métodos. Estudio descriptivo transversal de 152 altas hospitalarias. Incluye un total de 35 ítems agrupados. Para la evaluación del IAH valoramos la ausencia y el déficit de información. El criterio de adecuación se fijó por consenso en la cumplimentación del 90% de los ítems de forma correcta. Con el fin de conocer la fiabilidad de los resultados obtenidos se realizó la evaluación por dos revisores de forma independiente y en caso de discordancia se tomó la decisión por consenso tras revisar la historia clínica. Resultados. El 53,94% de los IAH disponen del 90% de los ítems completos y correctos del modelo de alta de nuestro Servicio. El 10,74% presentan alguna ausencia y el 65,79% de IAH presentan algún déficit de información. Se observa una variabilidad importante en la cumplimentación según el tipo de ítem analizado. Conclusiones. Nuestro trabajo valora la calidad de un modelo específico de IAH con ítems previamente seleccionados, considerados útiles y adecuados para reflejar de forma completa, exacta y precisa el proceso asistencial que recibe el paciente y detecta que los ítems: teléfono, residente, fechas de consulta, biopsia y de informe de biopsia, cirugía mayor ambulatoria e intervención urgente deben mejorarse(AU)

Objectives. To determine the quality and compliance to the information contained in the hospital discharge registry (HDR) issued by the Department of Oral and Maxillofacial Surgery in our hospital. Materials and Methods. A cross-sectional descriptive study was conducted to evaluate 152 HDR reports. These reports included a total of 35 items. We observed that there was a lack of information and some mistakes when filling the HDR boxes. Suitability criteria were set up by consensus as the completion of 90% of the items examined. To evaluate the reliability of the results, an assessment was performed by two reviewers independently, and in case of disagreement the decision was made by consensus after reviewing the medical record. Results. Only 53.94% of the HDR had 90% of the items completed appropriately; 10.74% had some items missing when filling in the form, and 65.79% lacked some information. Depending on the type of item there was a significant variation in the completion of the form. Conclusions. In the present work, we assess the quality of a specific hospital discharge form in our hospital, with items previously selected as useful and appropriate to reflect a complete, accurate and precise view of the care process of the patient, and improvements were needed in items such as, telephone, home address, date of consultation, biopsy report and the date it was performed, ambulatory surgery and emergency response(AU)

Criterios ecográficos de malignidad en adenopatías cervicales subclínicas de pacientes con carcinoma epidermoide oral / Ultrasound characteristics of malignant sub-clinical cervical lymph nodes in patients with oral epidermoid carcinoma

El carcinoma epidermoide de cavidad oral produce metástasis cervicales subclínicas en el 30-40% de los casos, lo que justifica la disección cervical electiva profiláctica dentro del tratamiento. La disponibilidad de pruebas diagnósticas que nos permitiesen detectar dichas metástasis evitaría el sobretratamiento del 60-70% de los pacientes, así como el coste y la morbilidad asociados. La ecografía cervical detecta las metástasis subclínicas con una sensibilidad y especificidad variables. Objetivos: Usar la ecografía para la valoración de adenopatías cervicales metastásicas antes de plantear el tratamiento quirúrgico. Material y método: Hemos realizado un estudio de seguimiento prospectivo de pacientes diagnosticados de carcinoma epidermoide de cavidad oral en estadio precoz (I-II) a los que se les ha efectuado un estudio ecográfico cervical (con longitud de onda larga) antes del tratamiento quirúrgico. Hemos revisado y aplicado diferentes criterios de malignidad obtenidos de los estudios publicados. Hemos comparado los datos de la ecografía con los resultados del estudio anatomopatológico de la disección cervical que hemos usado como patrón oro de metástasis. Resultados: Tras haber estudiado a 48 pacientes diagnosticados de carcinoma oral estadio I-II (34 hombres y 14 mujeres, con edad media de 50 años), a los que se ha realizado la disección cervical, se han detectado adenopatías metastásicas en el 30%. Con nuestros criterios utilizados para la detección de metástasis por ecografía, hemos obtenido una sensibilidad de hasta el 0,93 y un especificidad de hasta el 0,91, en función de los criterios utilizados(AU)

Oral carcinoma of oral cavity spread subclinical neck metastasis in 30-40%, this situation justify elective neck dissection in treatment. The availability of diagnostic test that allow detect neck metastasis would avoid overtreatment in 60-70% of patients with cost and morbidity associated. Neck ultrasound detect subclinical metastasis with different sensitivity and specificity. Objectives: Use ultrasound for detect metastatic lymph nodes before surgical treatment. Materials and method: We make a prospective follow up of patients with diagnosis squamous carcinoma of oral cavity in stage I-II in our services. We make an ultrasound study (with long wave) before surgery treatment. We check and apply different malignant criteria that we get from literature. We compare ultrasound information with pathological results of cervical dissection, this is our gold standard for metastasis. Results: We studied 48 patients with diagnostic of oral carcinoma in stage I-II, 34 men and 14 women with medium age of 50 years old. We make neck dissection, and we find metastatic lymph nodes in 30%, with our criteria for detection of metastatic lymph node with ultrasound we obtain a sensitivity until 0.93 and a specificity until 0.91 depend on used criteria(AU)