Giant cell interstitial pneumonia: an unusual finding in a case of preoperative death.

Giant cell interstitial pneumonia (GIP) is an exceedingly rare, debatable, perplexing, occupational lung disease, which most commonly affects individuals exposed to hard metal dust. We report a case of GIP in a 60-year-old man, scheduled for coronary artery bypass graft surgery and died during induction of general anesthesia despite all efforts to resuscitate him. Patient's relatives lodged complaint with the police alleging the negligence by the attending physicians. Despite inaccessible data pertaining to the occupation, clinical history, and radiographic findings, the diagnosis was GIP due to the presence of intra-alveolar, bizarre, "cannibalistic" multinucleated giant cells-the histologic sine qua non of GIP. To the best of our knowledge, this is the first case report of GIP in the world literature that was diagnosed on histopathologic examination of lung tissue obtained at medicolegal autopsy.

Histopathological Study of Spectrum of Lesions of Uterine Cervix.

Context: Uterine cervix is a gateway to several neoplastic and nonneoplastic lesions. Cervical carcinoma accounts for 20%-25% of all cancers and 80%-85% of all genital tract cancers worldwide. It is the most common malignancy in Indian women. Aim: The aim of this study was to study the histopathological spectrum, incidence, and distribution with respect to the age of various cervical lesions and to determine their clinicopathological correlation. Settings and Design: A prospective observational study of 200 cases of cervical lesions was carried out in the histopathology section of the Department of Pathology for the duration of 2 years after obtaining permission from the Institutional Ethics Committee. Materials and Methods: Study participants were selected from the study population admitted at the study center based on the inclusion and exclusion criteria. Statistical Analysis Used: Statistical software GraphPad InStat.v3.0 was used for statistical analysis. Results: In our study, 49.5% of cases were malignant and 50.5% of cases were benign. The most common malignant lesion on histopathological examination was squamous cell carcinoma (SCC). Majority of the lesions were in the 41-50 years of age group. Clinicopathological agreement was noted in 93.5% of cases. Twenty-eight out of 30 cases of SCC (93.33%) were positive for p16 staining. Agreement between Pap smear findings and histopathological diagnosis was 100% in cases of malignant and premalignant lesions of the cervix. Conclusion: Histopathological examination is important not only for confirmation of the preoperative diagnosis but also in evaluating the incidence and age-wise distribution of both neoplastic and nonneoplastic cervical lesions. Early and accurate diagnosis of cervical lesions provides an opportunity for appropriate interventions to prevent further complications.

Urinary bladder hemangioma -a rare urinary bladder tumor in a child.

Urinary bladder hemangiomas are rare, accounting for 0.6% of the urinary bladder tumors. Hemangioma is considered arising from embryonic stem cells of an angioblastic lineage. A 3-year old boy presented with hematuria. He had past operative history of excision of extensive lymphatic malformation involving retroperitoneum, pelvis and upper thigh. Computed tomography scan of abdomen and pelvis with contrast revealed a large soft tissue mass arising from the dome of the bladder. Partial cystectomy was done. Histopathology confirmed the mass as cavernous hemangioma of urinary bladder.

Posthysterectomy fallopian tube prolapse.

Fallopian tube prolapse into the vaginal vault is a rare complication after hysterectomy with adnexal preservation. It can occur following vaginal and abdominal hysterectomy, and rarely following interposition and colpotomy. Histopathology is the only means of definitive diagnosis. Prevention of tubal prolapse can be achieved by suturing the adnexae high in the pelvis at abdominal hysterectomy, and the incidence decreases if the pelvic peritoneum is closed properly.