Búsqueda | Biblioteca Virtual en Salud Odontología. Uruguay

1.

Brain-specific deletion of GIT1 impairs cognition and alters phosphorylation of synaptic protein networks implicated in schizophrenia susceptibility.

Fass, Daniel M; Lewis, Michael C; Ahmad, Rushdy; Szucs, Matthew J; Zhang, Qiangge; Fleishman, Morgan; Wang, Dongqing; Kim, Myung Jong; Biag, Jonathan; Carr, Steven A; Scolnick, Edward M; Premont, Richard T; Haggarty, Stephen J.

Mol Psychiatry ; 27(8): 3272-3285, 2022 08.

Artículo en Inglés | MEDLINE | ID: mdl-35505090

2.

The schizophrenia-associated variant in SLC39A8 alters protein glycosylation in the mouse brain.

Mealer, Robert G; Williams, Sarah E; Noel, Maxence; Yang, Bo; D'Souza, Alexandria K; Nakata, Toru; Graham, Daniel B; Creasey, Elizabeth A; Cetinbas, Murat; Sadreyev, Ruslan I; Scolnick, Edward M; Woo, Christina M; Smoller, Jordan W; Xavier, Ramnik J; Cummings, Richard D.

Mol Psychiatry ; 27(3): 1405-1415, 2022 03.

Artículo en Inglés | MEDLINE | ID: mdl-35260802

3.

Aberrant glycosylation in schizophrenia: a review of 25 years of post-mortem brain studies.

Williams, Sarah E; Mealer, Robert G; Scolnick, Edward M; Smoller, Jordan W; Cummings, Richard D.

Mol Psychiatry ; 25(12): 3198-3207, 2020 12.

Artículo en Inglés | MEDLINE | ID: mdl-32404945

4.

Glycobiology and schizophrenia: a biological hypothesis emerging from genomic research.

Mealer, Robert G; Williams, Sarah E; Daly, Mark J; Scolnick, Edward M; Cummings, Richard D; Smoller, Jordan W.

Mol Psychiatry ; 25(12): 3129-3139, 2020 12.

Artículo en Inglés | MEDLINE | ID: mdl-32377000

5.

Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry.

Bigdeli, Tim B; Genovese, Giulio; Georgakopoulos, Penelope; Meyers, Jacquelyn L; Peterson, Roseann E; Iyegbe, Conrad O; Medeiros, Helena; Valderrama, Jorge; Achtyes, Eric D; Kotov, Roman; Stahl, Eli A; Abbott, Colony; Azevedo, Maria Helena; Belliveau, Richard A; Bevilacqua, Elizabeth; Bromet, Evelyn J; Byerley, William; Carvalho, Celia Barreto; Chapman, Sinéad B; DeLisi, Lynn E; Dumont, Ashley L; O'Dushlaine, Colm; Evgrafov, Oleg V; Fochtmann, Laura J; Gage, Diane; Kennedy, James L; Kinkead, Becky; Macedo, Antonio; Moran, Jennifer L; Morley, Christopher P; Dewan, Mantosh J; Nemesh, James; Perkins, Diana O; Purcell, Shaun M; Rakofsky, Jeffrey J; Scolnick, Edward M; Sklar, Brooke M; Sklar, Pamela; Smoller, Jordan W; Sullivan, Patrick F; Macciardi, Fabio; Marder, Stephen R; Gur, Ruben C; Gur, Raquel E; Braff, David L; Nicolini, Humberto; Escamilla, Michael A; Vawter, Marquis P; Sobell, Janet L; Malaspina, Dolores.

Mol Psychiatry ; 25(10): 2455-2467, 2020 10.

Artículo en Inglés | MEDLINE | ID: mdl-31591465

6.

De novo mutations in schizophrenia implicate synaptic networks.

Fromer, Menachem; Pocklington, Andrew J; Kavanagh, David H; Williams, Hywel J; Dwyer, Sarah; Gormley, Padhraig; Georgieva, Lyudmila; Rees, Elliott; Palta, Priit; Ruderfer, Douglas M; Carrera, Noa; Humphreys, Isla; Johnson, Jessica S; Roussos, Panos; Barker, Douglas D; Banks, Eric; Milanova, Vihra; Grant, Seth G; Hannon, Eilis; Rose, Samuel A; Chambert, Kimberly; Mahajan, Milind; Scolnick, Edward M; Moran, Jennifer L; Kirov, George; Palotie, Aarno; McCarroll, Steven A; Holmans, Peter; Sklar, Pamela; Owen, Michael J; Purcell, Shaun M; O'Donovan, Michael C.

Nature ; 506(7487): 179-84, 2014 Feb 13.

Artículo en Inglés | MEDLINE | ID: mdl-24463507

7.

A polygenic burden of rare disruptive mutations in schizophrenia.

Purcell, Shaun M; Moran, Jennifer L; Fromer, Menachem; Ruderfer, Douglas; Solovieff, Nadia; Roussos, Panos; O'Dushlaine, Colm; Chambert, Kimberly; Bergen, Sarah E; Kähler, Anna; Duncan, Laramie; Stahl, Eli; Genovese, Giulio; Fernández, Esperanza; Collins, Mark O; Komiyama, Noboru H; Choudhary, Jyoti S; Magnusson, Patrik K E; Banks, Eric; Shakir, Khalid; Garimella, Kiran; Fennell, Tim; DePristo, Mark; Grant, Seth G N; Haggarty, Stephen J; Gabriel, Stacey; Scolnick, Edward M; Lander, Eric S; Hultman, Christina M; Sullivan, Patrick F; McCarroll, Steven A; Sklar, Pamela.

Nature ; 506(7487): 185-90, 2014 Feb 13.

Artículo en Inglés | MEDLINE | ID: mdl-24463508

8.

The Path to New Therapies for Schizophrenia and Bipolar Illness.

Scolnick, Edward M.

FASEB J ; 31(4): 1254-1259, 2017 04.

Artículo en Inglés | MEDLINE | ID: mdl-28360375

9.

A Manhattan Project against COVID.

Scolnick, Edward M; Saphire, Erica Ollmann.

FASEB J ; 36(2): e22117, 2022 02.

Artículo en Inglés | MEDLINE | ID: mdl-35060642

10.

Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.

Raychaudhuri, Soumya; Plenge, Robert M; Rossin, Elizabeth J; Ng, Aylwin C Y; Purcell, Shaun M; Sklar, Pamela; Scolnick, Edward M; Xavier, Ramnik J; Altshuler, David; Daly, Mark J.

PLoS Genet ; 5(6): e1000534, 2009 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-19557189

11.

Mammalian brain glycoproteins exhibit diminished glycan complexity compared to other tissues.

Williams, Sarah E; Noel, Maxence; Lehoux, Sylvain; Cetinbas, Murat; Xavier, Ramnik J; Sadreyev, Ruslan I; Scolnick, Edward M; Smoller, Jordan W; Cummings, Richard D; Mealer, Robert G.

Nat Commun ; 13(1): 275, 2022 01 12.

Artículo en Inglés | MEDLINE | ID: mdl-35022400

12.

Regulation of purine metabolism connects KCTD13 to a metabolic disorder with autistic features.

Madison, Jon M; Duong, Karen; Vieux, Ellen F; Udeshi, Namrata D; Iqbal, Sumaiya; Requadt, Elise; Fereshetian, Shaunt; Lewis, Michael C; Gomes, Antonio S; Pierce, Kerry A; Platt, Randall J; Zhang, Feng; Campbell, Arthur J; Lal, Dennis; Wagner, Florence F; Clish, Clary B; Carr, Steven A; Sheng, Morgan; Scolnick, Edward M; Cottrell, Jeffrey R.

iScience ; 24(1): 101935, 2021 Jan 22.

Artículo en Inglés | MEDLINE | ID: mdl-33409479

13.

The schizophrenia risk locus in SLC39A8 alters brain metal transport and plasma glycosylation.

Mealer, Robert G; Jenkins, Bruce G; Chen, Chia-Yen; Daly, Mark J; Ge, Tian; Lehoux, Sylvain; Marquardt, Thorsten; Palmer, Christopher D; Park, Julien H; Parsons, Patrick J; Sackstein, Robert; Williams, Sarah E; Cummings, Richard D; Scolnick, Edward M; Smoller, Jordan W.

Sci Rep ; 10(1): 13162, 2020 08 04.

Artículo en Inglés | MEDLINE | ID: mdl-32753748

14.

Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome.

McCamphill, Patrick K; Stoppel, Laura J; Senter, Rebecca K; Lewis, Michael C; Heynen, Arnold J; Stoppel, David C; Sridhar, Vinay; Collins, Katie A; Shi, Xi; Pan, Jen Q; Madison, Jon; Cottrell, Jeffrey R; Huber, Kimberly M; Scolnick, Edward M; Holson, Edward B; Wagner, Florence F; Bear, Mark F.

Sci Transl Med ; 12(544)2020 05 20.

Artículo en Inglés | MEDLINE | ID: mdl-32434848

15.

Regulation of gene expression by lithium and depletion of inositol in slices of adult rat cortex.

Brandish, Philip E; Su, Ming; Holder, Daniel J; Hodor, Paul; Szumiloski, John; Kleinhanz, Robert R; Forbes, Jaime E; McWhorter, Mollie E; Duenwald, Sven J; Parrish, Mark L; Na, Sang; Liu, Yuan; Phillips, Robert L; Renger, John J; Sankaranarayanan, Sethu; Simon, Adam J; Scolnick, Edward M.

Neuron ; 45(6): 861-72, 2005 Mar 24.

Artículo en Inglés | MEDLINE | ID: mdl-15797548

16.

Mechanisms of action of medicines for schizophrenia and bipolar illness: status and limitations.

Scolnick, Edward M.

Biol Psychiatry ; 59(11): 1039-45, 2006 Jun 01.

Artículo en Inglés | MEDLINE | ID: mdl-16616720

17.

A cell-based ultra-high-throughput screening assay for identifying inhibitors of D-amino acid oxidase.

Brandish, Philip E; Chiu, Chi-Sung; Schneeweis, Jonathan; Brandon, Nicholas J; Leech, Clare L; Kornienko, Oleg; Scolnick, Edward M; Strulovici, Berta; Zheng, Wei.

J Biomol Screen ; 11(5): 481-7, 2006 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-16760370

18.

Schizophrenia: do the genetics and neurobiology of neuregulin provide a pathogenesis model?

Scolnick, Edward M; Petryshen, Tracey; Sklar, Pamela.

Harv Rev Psychiatry ; 14(2): 64-77, 2006.

Artículo en Inglés | MEDLINE | ID: mdl-16603473

19.

Developing novel treatments for mood disorders: accelerating discovery.

Tamminga, Carol A; Nemeroff, Charles B; Blakely, Randy D; Brady, Linda; Carter, Cameron S; Davis, Kenneth L; Dingledine, Raymond; Gorman, Jack M; Grigoriadis, Dimitri E; Henderson, David C; B Innis, Robert B; Killen, John; Laughren, Thomas P; McDonald, William M; M Murphy, Greer M; Paul, Steven M; Rudorfer, Matthew V; Sausville, Edward; Schatzberg, Alan F; Scolnick, Edward M; Suppes, Trisha.

Biol Psychiatry ; 52(6): 589-609, 2002 Sep 15.

Artículo en Inglés | MEDLINE | ID: mdl-12361670

20.

High-throughput cell-based screening using scintillation proximity assay for the discovery of inositol phosphatase inhibitors.

Zheng, Wei; Brandish, Philip E; Kolodin, D Garrett; Scolnick, Edward M; Strulovici, Berta.

J Biomol Screen ; 9(2): 132-40, 2004 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-15006136

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