[Effect of hormones of the neurohypophysis on different types of behavioral responses in the rat]. / Deistvie gormonov neirogipofiza na razlichnye tipy povedencheskikh reaktsii u krys.

In experiments on male rats arginyl-vasopressin (AVP), lysyl-vasopressin (LVP) and vasotocin (VT) in doses of 0.005-0.010 mg/kg decreased motor activity and emotional behaviour in the open field test. In a dose of 0.001 mg/kg AVP significantly accelerated the elaboration of active avoidance; oxytocin delayed it, but LVP and VT had no significant influence. AVP also somewhat attenuated the elaboration of passive avoidance. None of the four studied peptides significantly affected the rate of elaboration of conditioned food-rewarded reaction to place.

[Effect of naloxone on hypoalgesia in rats exposed to prolonged immobilization stress]. / Vliianie naloksona na gipoalgeziiu u krys v usloviiakh dlitel'nogo immobilizatsionnogo stressa.

Significant hypoalgesia (tail-flick reflex at 60 degrees C) was observed in rats during the whole period of 24-hour immobilization in cramped cages, as compared to food-and-water deprived and control animals. This hypoalgesia was not antagonized by naloxone (1 mg/kg), however, the animals periodically receiving the drug during immobilization revealed aggressiveness and significant hypoalgesia after immobilization was discontinued (30-120 min observation).

[Effect of lysyl vasopressin and vasotocin on a disorder of the conditioned avoidance reaction by a serotonin receptor blockader]. / Vliianie lizilvazopressina i vazototsina na narushenie vyrabotki uslovnoi reaktsii izbeganiia blokatorom serotonimovykh retseptorov.

A study was made of the effect of systemic injection of lys8-vasopressin (LVP) and Arg8-vasotocin (AVT) on avoidance reaction in male rats. Both the compounds had no appreciable effect on the rate of the formation. However, in the presence of learning disorders induced by cyproheptadine. LVP completely and AVT partially recovered the normal time course of learning.

[The elimination of disorders in the acquisition of a conditioned active avoidance reaction by using the C-termination fragment of lysyl vasopressin]. / Ustranenie narushenii vyrabotki uslovnoi reaktsii aktivnogo izbeganiia C-kontsevym fragmentom lizilvazopressina.

In experiments with male white rats it was shown that 0.001 and 0.01 mg/kg of lysyl vasopressin C-terminal fragment--Pro-Lys-Gly (PLG) being injected intraperitoneally fails to influence the acquisition of active and passive avoidance and also T-maze food rewarded behaviour. The injection of PLG removed by disturbances of active avoidance caused by cyproheptadine and oxytocin. The inhibition of passive avoidance and food-rewarded behaviour was not removed by PLG.

[Reaction of deamination of monoamines in the brain and heart of rats under the toxic action of hyperbaric oxygenation]. / Reaktsiia dezaminirovaniia monoaminov v mozge i serdtse krys pri toksicheskom deistvii giperbaricheskoi oksigenatsii.

Kinetic parameters of monoamine deamination processes in the rat brain and heart after hyperbaric oxygenation (HBO) in toxic conditions (6 ata) were studied. HBO was shown to cause a substantial reduction in MAO affinity to serotonin in the brain, but not in the heart. Contrastingly, MAO affinity to dopamine was found to decrease in the heart, but not in the brain in response to HBO. Differences of tyramine and 2-phenylethylamine deamination in the rat brain and heart were also reciprocal following toxic HBO. In the initial phase of seizure episode MAO activity in the brain and heart was also different. Distinct mechanisms of adaptation to toxic oxygen in the central nervous system and cardiovascular system are discussed.

[The biological mechanisms of a congenital predisposition to alcoholism]. / Nekotorye biologicheskie mekhanizmy vrozhdennoi predraspolozhennosti k alkogolizmu.

In descendants of white rats with chronic alcoholic intoxication, the contents of DA in the brain and blood plasma, characteristics of GABA and opiate brain receptors, the contents of cAMP and other substances were studied as well as the c-fos gene expression. The data obtained suggest a considerable role of the changes in the DA system functions in the genesis of pathology in these descendants.