Detalles de la búsqueda
1.
Discovery, synthesis, activities, structure-activity relationships, and clinical development of combretastatins and analogs as anticancer drugs. A comprehensive review.
Nat Prod Rep
; 41(2): 298-322, 2024 Feb 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-38009216
2.
History and Prospects of Drug Discovery and Development Collaboration between Industry and Academia.
J Nat Prod
; 87(4): 1235-1245, 2024 Apr 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-38554098
3.
Structure activity relationship of N-1 substituted 1,5-naphthyrid-2-one analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-9).
Bioorg Med Chem Lett
; 75: 128808, 2022 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35609741
4.
Discovery and Development of Dolastatin 10-Derived Antibody Drug Conjugate Anticancer Drugs.
J Nat Prod
; 85(3): 666-687, 2022 03 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-35072477
5.
Nocathiacin, Thiazomycin, and Polar Analogs Are Highly Effective Agents against Toxigenic Clostridioides difficile.
J Nat Prod
; 85(4): 1141-1146, 2022 04 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-35380836
6.
Rapid, Selective, and Sensitive Method for Semitargeted Discovery of Congeneric Natural Products by Liquid Chromatography Tandem Mass Spectrometry.
J Nat Prod
; 84(3): 814-823, 2021 03 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-33523676
7.
Using [2H]water to quantify the contribution of de novo palmitate synthesis in plasma: enabling back-to-back studies.
Am J Physiol Endocrinol Metab
; 315(1): E63-E71, 2018 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29351479
8.
In Vitro and In Vivo Characterization of the Novel Oxabicyclooctane-Linked Bacterial Topoisomerase Inhibitor AM-8722, a Selective, Potent Inhibitor of Bacterial DNA Gyrase.
Antimicrob Agents Chemother
; 60(8): 4830-9, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27246784
9.
Discovery and development of kibdelomycin, a new class of broad-spectrum antibiotics targeting the clinically proven bacterial type II topoisomerase.
Bioorg Med Chem
; 24(24): 6291-6297, 2016 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27143131
10.
Kibdelomycin is a bactericidal broad-spectrum aerobic antibacterial agent.
Antimicrob Agents Chemother
; 59(6): 3474-81, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25845866
11.
Structure activity relationship of C-2 ether substituted 1,5-naphthyridine analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-5).
Bioorg Med Chem Lett
; 25(17): 3630-5, 2015 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26152426
12.
Structure activity relationship of pyridoxazinone substituted RHS analogs of oxabicyclooctane-linked 1,5-naphthyridinyl novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-6).
Bioorg Med Chem Lett
; 25(17): 3636-43, 2015 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26141771
13.
Hydroxy tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of RHS moiety (Part-3).
Bioorg Med Chem Lett
; 25(12): 2473-8, 2015 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25978963
14.
Structure activity relationship of substituted 1,5-naphthyridine analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-4).
Bioorg Med Chem Lett
; 25(11): 2409-15, 2015 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25911300
15.
Tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of left-hand-side moiety (Part-2).
Bioorg Med Chem Lett
; 25(9): 1831-5, 2015 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25851938
16.
Cyclic colisporifungin and linear cavinafungins, antifungal lipopeptides isolated from Colispora cavincola.
J Nat Prod
; 78(3): 468-75, 2015 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-25636062
17.
Structure of the bacterial deacetylase LpxC bound to the nucleotide reaction product reveals mechanisms of oxyanion stabilization and proton transfer.
J Biol Chem
; 288(47): 34073-34080, 2013 Nov 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-24108127
18.
Discovery and development of first in class antifungal caspofungin (CANCIDAS®)--a case study.
Nat Prod Rep
; 31(1): 15-34, 2014 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-24270605
19.
Kibdelomycin is a potent and selective agent against toxigenic Clostridium difficile.
Antimicrob Agents Chemother
; 58(4): 2387-92, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24514098
20.
Circumambulatory movement of negative charge ("ring walk") during gas-phase dissociation of 2,3,4-trimethoxybenzoate anion.
J Org Chem
; 79(10): 4378-89, 2014 May 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-24749904