RESUMEN
Four patients with fresh Hodgkin's disease were treated with MOPP/ABV hybrid regimen using nitrogen mustard-N-oxide hydrochloride (NH2-O). All patients responded well to this therapy and achieved complete remission. Toxicity was minimum except for an older patient. He was 70 years old and developed arrhythmia after MOPP therapy but recovered without any treatment. The continuation of therapy was possible by dose reduction in this case. We conclude MOPP/ABV regimen using NH2-O is valuable for the treatment of Hodgkin's disease.
Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Enfermedad de Hodgkin/tratamiento farmacológico , Adulto , Anciano , Bleomicina/administración & dosificación , Doxorrubicina/administración & dosificación , Esquema de Medicación , Femenino , Humanos , Masculino , Mecloretamina/administración & dosificación , Persona de Mediana Edad , Prednisona/administración & dosificación , Procarbazina/administración & dosificación , Inducción de Remisión , Vinblastina/administración & dosificación , Vincristina/administración & dosificaciónAsunto(s)
Tetraciclina/farmacología , Adulto , Anciano , Animales , Bilis/metabolismo , Encéfalo/metabolismo , Colitis/tratamiento farmacológico , Perros , Heces/análisis , Femenino , Humanos , Mucosa Intestinal/metabolismo , Riñón/metabolismo , Hígado/metabolismo , Pulmón/metabolismo , Masculino , Ratones , Pruebas de Sensibilidad Microbiana , Persona de Mediana Edad , Pielitis/tratamiento farmacológico , Infecciones del Sistema Respiratorio/tratamiento farmacológico , Bazo/metabolismo , Infecciones Estafilocócicas/tratamiento farmacológico , Staphylococcus/efectos de los fármacos , Tetraciclina/efectos adversos , Tetraciclina/sangre , Tetraciclina/metabolismo , Tetraciclina/uso terapéutico , Tetraciclina/orinaAsunto(s)
Rifampin , Administración Oral , Adulto , Dieta , Dimetilformamida , Ayuno , Humanos , Masculino , Piperidinas/administración & dosificación , Piperidinas/sangre , Piperidinas/metabolismo , Piperidinas/orina , Rifampin/administración & dosificación , Rifampin/sangre , Rifampin/metabolismo , Rifampin/farmacología , Rifampin/orina , Solventes , Staphylococcus/efectos de los fármacos , SulfóxidosAsunto(s)
Cistadenocarcinoma Seroso/secundario , Neoplasias de las Trompas Uterinas/patología , Neoplasias Cardíacas/patología , Neoplasias Hepáticas/secundario , Células Neoplásicas Circulantes/patología , Vena Cava Inferior/patología , Femenino , Atrios Cardíacos , Humanos , Persona de Mediana Edad , Invasividad NeoplásicaRESUMEN
A 68-year-old man developed severe consciousness disturbance after daily administration of 20 mg omeprazole for four days for the treatment of bleeding gastric ulcer. Systemic investigation revealed severe hyponatremia (111 meq/liter). Consciousness did not become clear until his sodium intake was increased to 480 meq/day, and his serum sodium concentrations reached 130 meq/liter. After the discontinuation of omeprazole, his serum sodium levels returned to the normal range with only minimum supplementation of sodium in the form of dietary sodium chloride intake of 10 g/day. Although the mechanism of hyponatremia induced by omeprazole is not clear, an excessive loss of urinary sodium appears to be more likely than water retention with an increase in fluid intake. The literature was also reviewed.