A Randomized Control Trial for Evaluating Efficacies of Two Online Cognitive Interventions With and Without Fear-Appeal Imagery Approaches in Preventing Unprotected Anal Sex Among Chinese Men Who Have Sex with Men.

Fear appeal approach has been used in health promotion, but its effectiveness has been mixed. It has not been well applied to HIV prevention among men who have sex with men (MSM). The present study developed and evaluated the relative efficacy of three online interventions (SC: STD-related cognitive approach, SCFI: STD-related cognitive plus fear appeal imagery approach, Control: HIV-related information based approach) in reducing prevalence of unprotected anal intercourse (UAI) among 396 MSM using a randomized controlled trial design. Participants' levels of fear-related emotions immediately after watching the assigned intervention materials were also assessed. Participants were evaluated at baseline and 3 months after the intervention. Results showed that participants in the SCFI scored significantly higher in the instrument assessing fear after the watching the intervention materials. However, no statistically significant differences were found across the three groups in terms of UAI at Month 3. Some significant within-group reductions in some measures of UAI were found in three groups. Further studies are warranted to test the role of fear appeal in HIV prevention.

The relationship between personality, social functioning, and depression: a structural equation modeling analysis.

The relationship between personality, social functioning, and depression remains unclear. The present study employs structural equation modeling to examine the mediating role of social functioning between harm avoidance (HA), self-directedness (SD), and depression. A sample of 902 individuals completed a self-report questionnaire consisting of the following scales: HA and SD subscales of the Temperament and Character Inventory (TCI), Beck Depression Inventory (BDI), and Social Adaptation Self-Evaluation Scale (SASS). Structural equation modeling via analysis of moment structure was used to estimate the fit of nine related models. Results indicated that social functioning is a mediator between harm avoidance or self-directness and depression. Self-directedness was also shown to have direct effects on depression. The results support the social reinforcement theory of depression and provide a theoretical account of how the variables are related based on correlation methods. Suggestions are offered for future experimental and longitudinal research.

Focusing too much on individualistic achievement may generate stress and negative emotion: Social rank theory perspective.

Individualistic achievement personality has been found to increase personal resources and reduce negative emotions. Whether individualistic achievement is protective against stress or negative emotion or indeed stress generating remains uncertain. The present study examined three models proposed to explain the interrelationship between individualistic achievement, personal resources, daily stress, and negative emotion. One hundred eighteen volunteers (aged 18-59 years; 39 males) were recruited from the community. On the first day of the study, they received copies of a questionnaire measuring daily stress to complete for the next 14 days. On the last day of the study, they filled in questionnaires measuring positive and negative affect, depression, social functioning and individualistic achievement personality. Individualistic achievement was significantly associated with positive affect and social functioning but not with negative affect, depression, and average daily stress. Structural equation modeling analysis showed a significant fit for a model indicating that individualistic achievement personality scores would be positively associated with both personal resources and daily stress, and subsequently personal resources would be negatively associated with negative emotion and daily stress positively associated with negative emotion. Individualistic achievement may be related to both advantages and disadvantages. Further investigation of the nature of individualistic achievement is warranted.

Caffeinated coffee enhances co-operative behavior in the Mixed Motive Game in healthy volunteers.

Caffeinated drinks are commonly consumed in social gatherings. However, their effects on social behavior remain unclear. The present study examined the effects of caffeinated coffee on antidepressant-related co-operative behavior. Seventy-seven low-caffeine users took part in a randomized, double-blind, cross-over study of single dose of caffeinated coffee (150 mg caffeine) and decaffeinated coffee (9 mg caffeine) with at least a 3-day washout period. In each session, participants were asked to imagine a fictitious person and play the Mixed Motive Game with that person 45 min after coffee consumption. Heart rate, blood pressure, and state moods were measured at baseline and at 45 min post-coffee consumption. After caffeinated coffee, participants exhibited significantly higher blood pressure. They also allocated significantly fewer scores to themselves and sent significantly more sadness message during the game. These results suggest that caffeinated coffee may help to improve social support and depressive symptoms.

Contrasting effects of a hot and a cool system in anger regulation on cooperative behaviours.

Angry mood and aggression are strongly associated. However, it is not socially acceptable to express strong aggression. Non-cooperative behaviours might be another aspect of aggressive behaviour. The present study examines the expression of non-cooperative behaviours after angry mood induction. Eighty-five university students were randomly assigned to hot or cool focus recall of a past angry event. At baseline, trait aggression and rejection sensitivity were evaluated. Just before the recall task, participants' state of angry mood was measured by the Anger Mood Scale. Then they engaged in either hot or cool focus recall of a past rejection event. Immediately after the mood induction, angry mood was measured again. They were then instructed to play the Mixed Motive game with an unknown person. Participants in both groups became angrier after the mood induction. One-way analysis of covariance, controlling for trait anger and rejection sensitivity, showed that the hot-focus participants gave significantly fewer points to the other person than the cool-focus participants. Participants high on trait aggression sent more verbally aggressive messages. The findings suggest that non-cooperative behaviour is another form of anger related aggression and might be more socially important than overt aggression.

Maternal oxytocin responsiveness improves specificity of positive social memory recall.

BACKGROUND: Oxytocin is related to positive parenting behaviours and social cognition. Long-term relationships are partly influenced by the social memory of a person. Positive social memory with the attachment figure may play a mediating role between oxytocin responsiveness and positive parenting behaviours. METHODOLOGY: The study recruited 61 pairs of married mothers and preschool children from a community in Hong Kong. Sociodemographic background and neuroticism data of the respondents were collected in a laboratory. Salivary oxytocin and current mood rating were obtained 10 and 15 min before and after free play, respectively. After collecting the second salivary oxytocin samples, the mothers engaged in a parenting recall task. RESULTS: The mothers with high oxytocin responsiveness recalled previous positive social events with great detail and used uncontrollability attribution to explain such positive events. DISCUSSION: Oxytocin responsiveness influenced the recall of positive social events and attribution. This influence may enhance the sensitivity and positive behaviours of parenting.

Psychometric analysis of the Chinese version of Social Adaptation Self-evaluation Scale (C-SASS).

There are only a very limited number of scales available to measure social motivation in Chinese. Studying social motivation might help researchers to understand more of the relationship between social skills and depression. An English version of the Social Adaptation Self-evaluation Scale (SASS) is a valid measure of social motivation. A Chinese translated version of the SASS was validated in 208 healthy volunteers, who were also evaluated with the Temperament and Character Inventory (TCI) and the Beck Depression Inventory (BDI). Principal Component Analysis showed the C-SASS had a one-factor solution. The Cronbach alpha of the scale was 0.97, but no item redundancy was found. The C-SASS was negatively associated with the BDI (r=-0.39) as predicted. Furthermore, the C-SASS was positively associated with the Cooperativeness (r=0.34) and Self-directedness factors (r=0.37), but negatively associated with the Harm Avoidance factor (r=-0.36) of the TCI as predicted. C-SASS scores were not associated with the Novelty Seeking or Self-transcendence factors of the TCI. Therefore, the C-SASS had adequate construct validity, and internal consistency. The results also supported the external validity, convergent validity and divergent validity of the C-SASS.

How does maternal oxytocin influence children's mental health problem and maternal mental health problem?

This study aims to explore the interrelationship among maternal oxytocin (OT) responsiveness, maternal mental health, maternal parenting behavior, and mental health of children under a free-play interaction. 61 mother-child dyads were recruited for the study. Maternal mental health problem and parenting self-efficacy were measured using self-reported questionnaires. The mental health problems of children were also evaluated using a mother-reported questionnaire. Furthermore, salivary OT was collected before and after a standardized 10min free-play interaction. Parenting behaviors, including eye gaze and touch, were measured during the free-play interaction. Maternal OT responsiveness was significantly associated with less maternal mental health problem, touch frequency, and mental health problem of children but not with parenting self-efficacy. In the multivariate linear regression analysis that considers maternal OT responsiveness and maternal and children's mental health problems, maternal OT responsiveness was not associated with the mental health problems of children. This result suggested that maternal mental health problem played a mediational role between maternal OT responsiveness and the mental health problem of children. Results supported the assertion that maternal OT responsiveness contributed to the increased risk of maternal mental health problems and, subsequently, the risk of mental health problems of their children.

Sex differences in cortisol response to reboxetine.

This study examined the cortisol response to reboxetine in a sample of healthy men and women. Forty healthy volunteers were randomly allocated to one of two treatment groups: placebo or 4 mg reboxetine under double-blind conditions. Saliva cortisol was measured pre, 1 and 1.5 h post-treatment. Mood and side-effects were also measured. A single oral dose of 4 mg reboxetine did not affect positive or negative mood but did produce some side-effects. It was also sufficient to increase cortisol release 1.5 h post-treatment compared to placebo. In addition, reboxetine lead to a significantly increased cortisol release in male compared to female volunteers. The results suggest that healthy male volunteers are more responsive to challenge with a noradrenergic compound than females.

Serotonergic intervention affects both social dominance and affiliative behaviour.

RATIONALE: Deficiencies in serotonin function have been associated with irritability and aggression but enhancing serotonin has also been shown to promote social status and affiliative behaviour in non-human primates and more recently in humans. OBJECTIVES: To investigate the effects of citalopram, a selective serotonin reuptake inhibitor (SSRI), on social behaviour with a flatmate and a stranger. METHODS: Ten pairs of healthy volunteers took part in a randomized double-blind crossover study of 2 weeks treatment with citalopram (20 mg/day) and placebo with a 2-week washout period. In each pair, one person (subject) took the tablets and the other (flatmate) received no treatment. On the last day of each treatment period, the subjects socially interacted with a confederate behaving as a responsive person in a stranger-dyadic social interaction paradigm. After the interaction, subjects played the Mixed-motive game, which measures cooperative behaviour and communication, with the confederate. The flatmates evaluated the social behaviour of the subjects before and at the end of the treatment periods. RESULTS: On citalopram, the subjects were rated as significantly less submissive by their flatmates and they showed a dominant pattern of eye contact in the stranger-dyadic social interaction paradigm. They also reduced the number of points they awarded themselves and sent more cooperative messages during the game. CONCLUSIONS: These results indicate that administration of an SSRI can modify social status in different interactions and increase affiliative behaviour. They implicate a role for serotonin in modulating social aspects of behaviour.

Difference in serotonergic and noradrenergic regulation of human social behaviours.

RATIONALE: Treatment with antidepressants has been shown to affect social functioning, but drugs with actions on different neurotransmitters may have a different profile of effects. OBJECTIVE: To study the effects of acute manipulation of two neurotransmitters, serotonin and noradrenaline, on social behaviour in healthy volunteers. METHODS: Sixty volunteers were randomly assigned to a single dose of a selective noradrenaline reuptake inhibitor, reboxetine (4 mg), a selective serotonin reuptake inhibitor, citalopram (10 mg), or placebo. They socially interacted with a confederate behaving in a non-sociable manner in a stranger-dyadic social interaction paradigm 1.5 h postdrug. Social behaviour during the interaction was video recorded by a hidden camera and subsequently analysed. After the interaction, volunteers played the mixed-motive game with the confederate. This game has been shown to measure cooperative behaviour and communication. Volunteers read a short story and rated their mood predrug and before and after the interaction. RESULTS: Subjects on reboxetine showed reduced hand fiddling during the interaction and gave significantly more cooperative communications during the mixed-motive game. More volunteers on reboxetine were classified as cooperative players. On the reading task, the speech of subjects on citalopram showed less reduction of energy variation after the social interaction. CONCLUSION: Reboxetine had clear effects on social behaviour. Noradrenaline was related to increased social engagement and cooperation and a reduction in self-focus. Citalopram had less effect on cooperative behaviour but serotonin may be associated with protection of the self from the negative consequences of social interaction.

Consequences of displaying abnormal social behaviour: avoidance and reduction of social reinforcement.

BACKGROUND: Abnormal social behaviour, which is a common feature of psychiatric disorders, is associated with rejection. A passive lack of participation or involvement has been studied as characteristic of depression but active forms of nonparticipation have received little experimental attention. This study examined the interpersonal consequences of four distinct types of social behaviour by using the role enactment method. Two of the roles portrayed abnormal social behaviour, active nonparticipant 'manic' and passive nonparticipant 'sad', and two portrayed normal social behaviour, active participant 'warm' and passive participant 'shy'. METHODS: Sixty-three normal subjects were randomly allocated to a brief dyadic social interaction with a confederate acting one of four roles. Subsequently, they rated their level of rejection of the confederate and took part in the mixed-motive game with him/her. RESULTS: The subjects were more likely to reject confederates in the abnormal social behaviour roles. This was shown on both their nonverbal behaviour and their verbal report. On the mixed-motive game, subjects gave fewer points and less cooperative and ingratiating messages to the confederates who had displayed abnormal social behaviour. LIMITATIONS: This result might only reveal the effects of first impressions of a confederate who behaves in a particular way, but not be generalised to long term acquaintanceship. CONCLUSIONS: These results extend previous findings that passive nonparticipant behaviour leads to rejection to active nonparticipant behaviour and show that the consequences of displaying such behaviour not only result in rejection but also in the reduction of social reinforcement. This might slow a patient's recovery process.

Reboxetine promotes social bonding in healthy volunteers.

Reboxetine is a novel antidepressant with a selective action on noradrenaline. In addition to its efficacy in depression, it has been found to improve social adaptation. The objective of this study was to assess the specific social behavioural effects of reboxetine which might be associated with social adaptation. Ten pairs of healthy volunteers took part in a randomized double-blind, crossover study of 2 weeks treatment with reboxetine (4 mg b.d.) and placebo with a 2-week washout period. In each pair, one person (subject) took the tablets and the other (flatmate) received no treatment. On the last day of each treatment period, the subjects socially interacted with a stranger (a confederate behaving as a responsive person) in a stranger-dyadic social interaction paradigm. After the interaction, subjects played the Mixed-Motive game, which measures cooperative behaviour and communication, with the confederate. Subjects read a short story before and after the social interaction. The flatmates evaluated the social behaviour of the subjects before and at the end of the two treatment periods. On reboxetine, the subjects were rated to be significantly more agreeable and cooperative (passive participant) and less submissive by their flatmates. They showed significantly less eye contact with the confederate in the social interaction paradigm and gave significantly fewer helplessness messages during the game. They spoke faster on the reading task after the social interaction. This study provides evidence that reboxetine increases cooperative social behaviour and increases social drive, which might be important for social adaptation.

Relationship between baseline cortisol, social functioning and depression: a mediation analysis.

Both elevated cortisol secretion and low social support have been commonly found in depressed patients, but their respective roles in depression remain unclear. In fact, it may not be a lack of social support but a failure to obtain it that is important. The present study used mediation analysis to study the interrelationships among cortisol, social functioning and depression. Sixty healthy volunteers were recruited from the community. Depression and social functioning were measured by the Beck Depression Inventory and the Social Adaptation Self-evaluation Scale, respectively. Salivary samples were collected to measure the cortisol. Using mediation analysis, it was found that elevated cortisol secretion was a vulnerability factor for low social functioning, leading to higher depression scores. Hypercortisolaemia may be a predisposing factor and may interact with a low level of social functioning leading to depression.

Using a partner's facial emotion to elucidate social dominance motivation induced by an SSRI.

Previous studies independently showed that acute treatment with a selective serotonin reuptake inhibitor (SSRI) enhanced happy face recognition, and dominance behaviors which might reflect enhancement of reward sensitivity. The present study aimed to determine whether such a mechanism would be related to social resource acquisition induced by an SSRI. Forty healthy subjects were recruited for the experiment. A randomized, double-blind, placebo-controlled crossover nested within confederate type (happy, fearful, or sad) trial of a single-dose of 10mg escitalopram versus placebo was conducted with a two-week washout period. In each of the treatment groups, the subjects interacted socially with one of the three types of confederate in a waiting room for 3-minute. Then, they went to an individual laboratory and were led to believe that they played the Mixed-motive game with the confederate. The game measures punitive/cooperative behaviors by how participants allocate higher/lower game scores to the confederate and communicate cooperation/ingratiation/helplessness/sadness/blaming/extrapunitive, messages to the confederate. Significant treatment-by-confederate type interactions were observed through game score distributions and ingratiation messages to the confederate and attentive eye gaze. In the happy confederate condition, escitalopram increased ingratiation messages and lowered points awarded to the confederate. In the fearful confederate condition, escitalopram increased ingratiation messages and reduced time spent looking away from the confederate. No changes in these measures were found in the sad confederate condition. Therefore acute escitalopram treatment enhances reward sensitivity to the facial emotions of social partners which in turn increases social resource acquisition and social dominance towards happy but not fearful social partners.

Facial emotion linked cooperation in patients with paranoid schizophrenia: a test on the Interpersonal Communication Model.

BACKGROUND: Patients with schizophrenia consistently show deficits in facial affect perception and social behaviours. It is illusive to suggest that these deficits in facial affect perception cause poor social behaviours. AIM: The present research aims to study how facial affects influence ingratiation, cooperation and punishment behaviours of the patients. METHODS: Forty outpatients with paranoid schizophrenia, 26 matched depressed patients and 46 healthy volunteers were recruited. After measurement of clinical symptoms and depression, their facial emotion recognition, neurocognitive functioning and the facial affects dependent cooperative behaviour were measured using a modified version of Mixed-Motive Game. RESULTS: The depressed control group showed demographic characteristics, depression levels and neurocognitive functioning similar to the schizophrenic group. Patients with schizophrenia committed significantly more errors in neutral face identification than the other two groups. They were significantly more punitive on the Mixed-Motive Game in the neutral face condition. CONCLUSION: Neutral face misidentification was a unique emotion-processing deficit in the schizophrenic group. Their increase in punitive behaviours in the neutral face condition might confuse their family members and trigger more expressed emotion from them, thus increasing the risk of relapse. Family members might display more happy faces to promote positive relationships with patients.

The impact of depression on social skills.

Social skills deficits are common among depressed patients, but little attention has been paid to this aspect of depression. In this review, the potential roles of different depressive factors contributing to poor social skills are examined. Specifically, the first part of the analysis is focused on how different depressive factors influence the three components of social behavior: perceptual, cognitive, and performance. In the second part, evidence is provided to support the proposition that social skills deficits are manifestations of state depressive factors. This is based on results from studies involving mood induction procedures, counter manipulation procedures, and treatment with antidepressant drugs. These deficits are therefore likely to remit with effective treatment.