1.
Br J Pharmacol
; 107(2): 273-5, 1992 Oct.
Artículo
en Inglés
| MEDLINE
| ID: mdl-1330170
RESUMEN
The non-peptide NK1 receptor antagonist, CP-96,345, and its 2R,3R enantiomer CP-96,344, which is not an NK1 receptor antagonist (IC50 > 10 microM), were evaluated for antinociceptive and anti-inflammatory activities in several classical models of pain and inflammation in the rat. Both CP-96,345 and CP-96,344 reduced carrageenin-induced paw oedema and hyperalgesia, and attenuated the second phase of formalin-induced paw licking with equal potency. These results indicate that NK1 antagonism is not responsible for the activity of (+/-)-CP-96,345 in the above animal models.
Asunto(s)
Compuestos de Bifenilo/farmacología , Inflamación/tratamiento farmacológico , Dolor/tratamiento farmacológico , Receptores de Neurotransmisores/antagonistas & inhibidores , Análisis de Varianza , Animales , Sitios de Unión , Modelos Animales de Enfermedad , Edema/inducido químicamente , Masculino , Dimensión del Dolor , Ratas , Ratas Sprague-Dawley , Receptores de Neuroquinina-2 , Estereoisomerismo
2.
Regul Pept
; 46(1-2): 433-6, 1993 Jul 02.
Artículo
en Inglés
| MEDLINE
| ID: mdl-7692559