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1.
Behav Brain Sci ; 45: e294, 2022 11 18.
Artículo en Inglés | MEDLINE | ID: mdl-36396396

RESUMEN

Dubourg and Baurmard ask why people consume fiction with imaginary worlds. We extend this inquiry to ask why people engage in creating imaginary worlds. In Fanfiction, the writing of fiction by fans involves both an immersive creative experience and a very interactive community that may explain the high (social) engagement of people with Fanfiction.

2.
J Acoust Soc Am ; 147(4): 3028, 2020 04.
Artículo en Inglés | MEDLINE | ID: mdl-32359331

RESUMEN

This paper investigates the acoustic correlates of word initial prominence and tone in Chácobo, a southern Pano language of the northern Bolivian Amazon. This paper reports the results of a production study with five speakers producing trisyllabic words with a word final high tone. It tests a claim found in the literature that there is an additional word-initial prominence in such forms and determines its acoustic correlates compared with high tone. This study used trisyllabic forms in morphophonological contexts where these forms would appear with a final high tone. In such forms, high tone and word-initial prominence do not overlap (e.g., "panaß̞í" "asaí"). The paper takes into account five acoustic correlates across the three syllables of these words: F1, F2, F0, duration, intensity. The paper finds that the initial syllable in these words shows a statistically significant increase in intensity. There is significant speaker variation with respect to whether duration is a correlation of initial stress and the results do not provide clear evidence that initial stress is marked with duration. The final high-tone marked syllables are distinguished based on an increase in F0 and secondarily with vowel duration. Whether pitch is also a correlate of stress requires future research. The paper interprets these results as suggesting that Chácobo is a language in which tone and stress co-exist. The study thus provides instrumental evidence for a phenomenon suggested to occur in some Pano languages. The limitations of this study, including the fact the results have more than one interpretation in light of current discussions concerning stress and tone, are also discussed.


Asunto(s)
Lenguaje , Acústica del Lenguaje , Acústica , Fonética
3.
Neuroimage ; 184: 349-358, 2019 01 01.
Artículo en Inglés | MEDLINE | ID: mdl-30219292

RESUMEN

Blood-brain barrier (BBB) breakdown has been hypothesized to play a key role in the onset and progression of Alzheimer's disease (AD). However, the question of whether AD itself contributes to loss of BBB integrity is still uncertain, as many in-vivo studies have failed to detect signs of AD-related BBB breakdown. We hypothesize AD-related BBB damage is subtle, and that these negative results arise from a lack of measurement sensitivity. With the aim of developing a more sensitive measure of BBB breakdown, we have designed a novel MRI scanning protocol to quantify the trans-BBB exchange of endogenous water. Using this method, we detect increased BBB water permeability in a rat model of AD that is associated with reduced expression of the tight junction protein occludin. BBB permeability to MRI contrast agent, assessed using dynamic contrast-enhanced (DCE)-MRI, did not differ between transgenic and wild-type animals and was uncorrelated with occludin expression. Our data supports the occurrence of AD-related BBB breakdown, and indicates that such BBB pathology is subtle and may be undetectable using existing 'tracer leakage' methods. Our validated water-exchange MRI method provides a new powerful tool with which to study BBB damage in-vivo.


Asunto(s)
Enfermedad de Alzheimer/patología , Barrera Hematoencefálica/patología , Imagen por Resonancia Magnética/métodos , Animales , Encéfalo/patología , Permeabilidad Capilar/fisiología , Ratas , Ratas Transgénicas , Agua/análisis
4.
Phys Rev Lett ; 123(11): 117401, 2019 Sep 13.
Artículo en Inglés | MEDLINE | ID: mdl-31573228

RESUMEN

Unexpected light propagation effects, such as negative refraction, have been reported in artificial media. Leveraging on the intersubband resonances in heterostructured semiconductors, we show that all possible optical regimes, ranging from classical dieletric and metal to hyperbolic metamaterial types 1 and 2, can be achieved. As a demonstration, we prove that the negative refraction effect can occur at a designed frequency by controlling the electronic quantum confinement.

5.
Conscious Cogn ; 74: 102794, 2019 09.
Artículo en Inglés | MEDLINE | ID: mdl-31376795

RESUMEN

Recent research suggests that eye contact can lead to enhanced self-awareness. A related phenomenon, the sense of agency deals with the notion of the self as the origin of our actions. Possible links between eye contact and agency have been so far neglected. Here, we investigated whether an implicit sense of agency could be modulated by eye gaze. We asked participants to respond (button press) to a face stimulus: looking or not at the participant (experiment 1); or displaying distinct eye gaze before or after a mask (experiment 2). After each trial, participants estimated the time between their key press and the ensuing effects. We found enhanced intentional binding for conditions that involved direct compared to averted gaze. This study supports the idea that eye contact is an important cue that affects complex cognitive processes and suggests that modulating self-processing can impact the sense of agency.


Asunto(s)
Ojo , Reconocimiento Facial/fisiología , Fijación Ocular/fisiología , Relaciones Interpersonales , Desempeño Psicomotor/fisiología , Adolescente , Adulto , Femenino , Humanos , Intención , Masculino , Adulto Joven
6.
J Neurosci Res ; 93(10): 1476-91, 2015 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-26010004

RESUMEN

Chronic stress promotes cognitive impairment and dendritic spine loss in hippocampal neurons. In this animal model of depression, spine loss probably involves a weakening of the interaction between pre- and postsynaptic cell adhesion molecules, such as N-cadherin, followed by disruption of the cytoskeleton. N-cadherin, in concert with catenin, stabilizes the cytoskeleton through Rho-family GTPases. Via their effector LIM kinase (LIMK), RhoA and ras-related C3 botulinum toxin substrate 1 (RAC) GTPases phosphorylate and inhibit cofilin, an actin-depolymerizing molecule, favoring spine growth. Additionally, RhoA, through Rho kinase (ROCK), inactivates myosin phosphatase through phosphorylation of the myosin-binding subunit (MYPT1), producing actomyosin contraction and probable spine loss. Some micro-RNAs negatively control the translation of specific mRNAs involved in Rho GTPase signaling. For example, miR-138 indirectly activates RhoA, and miR-134 reduces LIMK1 levels, resulting in spine shrinkage; in contrast, miR-132 activates RAC1, promoting spine formation. We evaluated whether N-cadherin/ß-catenin and Rho signaling is sensitive to chronic restraint stress. Stressed rats exhibit anhedonia, impaired associative learning, and immobility in the forced swim test and reduction in N-cadherin levels but not ß-catenin in the hippocampus. We observed a reduction in spine number in the apical dendrites of CA1 pyramidal neurons, with no effect on the levels of miR-132 or miR-134. Although the stress did not modify the RAC-LIMK-cofilin signaling pathway, we observed increased phospho-MYPT1 levels, probably mediated by RhoA-ROCK activation. Furthermore, chronic stress raises the levels of miR-138 in accordance with the observed activation of the RhoA-ROCK pathway. Our findings suggest that a dysregulation of RhoA-ROCK activity by chronic stress could potentially underlie spine loss in hippocampal neurons.


Asunto(s)
Cadherinas/metabolismo , Espinas Dendríticas/metabolismo , Depresión/patología , Hipocampo/patología , Neuronas/ultraestructura , Quinasas Asociadas a rho/metabolismo , Animales , Reacción de Prevención , Peso Corporal/fisiología , Depresión/etiología , Modelos Animales de Enfermedad , Masculino , MicroARNs/genética , MicroARNs/metabolismo , Neuronas/patología , Ratas , Ratas Sprague-Dawley , Estadísticas no Paramétricas , Estrés Fisiológico , Sacarosa/metabolismo , Edulcorantes/metabolismo , Natación/psicología , beta Catenina/genética , beta Catenina/metabolismo
7.
Cogn Emot ; 29(3): 460-70, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-24854042

RESUMEN

Our preferences are sensitive to social influences. For instance, we like more the objects that are looked-at by others than non-looked-at objects. Here, we explored this liking effect, using a modified paradigm of attention cueing by gaze. First, we investigated if the liking effect induced by gaze relied on motoric representations of the target object by testing if the liking effect could be observed for non-manipulable (alphanumeric characters) as well as for manipulable items (common tools). We found a significant liking effect for the alphanumeric items. Second, we tested if another type of powerful social cue could also induce a liking effect. We used an equivalent paradigm but with pointing hands instead of gaze cues. Pointing hands elicited a robust attention-orienting effect, but they did not induce any significant liking effect. This study extends previous findings and reinforces the view of eye gaze as a special cue in human interactions.


Asunto(s)
Afecto/fisiología , Atención/fisiología , Señales (Psicología) , Movimientos Oculares/fisiología , Adolescente , Adulto , Femenino , Humanos , Masculino , Estimulación Luminosa , Adulto Joven
8.
Food Technol Biotechnol ; 53(1): 48-56, 2015 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-27904331

RESUMEN

Instant whole beans obtained by drying at 25 °C were evaluated for their chemical, physicochemical, nutritional, microbiological, sensory and rehydration characteristics. The proximal composition of instant whole beans was typical of this kind of food, whereas aw and L*, a* and b* values were 0.639, 98.55, -0.28 and -1.52, respectively. In instant whole beans, 75% of the essential amino acids had a value greater or equal to the reference standard for adult humans; the protein quality in terms of chemical score was 95%. Microbiological counts of aerobic mesophilic bacteria, moulds, yeasts and total coliforms of rehydrated instant whole beans were <10 CFU/g, whereas the scores for colour, flavour, texture and overall acceptability were 7.22, 7.68, 7.24 and 7.34, respectively, on a 1-9 hedonic scale. The logarithmic and Pilosof models showed close fits (R2>0.99) to the experimental data for drying of cooked beans and rehydration of instant whole beans, respectively. In the light of the chemical, physicochemical, nutritional, microbiological, sensory and rehydration characteristics of instant whole beans found in this study, drying at 25 °C is recommended for the production of such food.

9.
J Food Sci Technol ; 52(5): 3079-85, 2015 May.
Artículo en Inglés | MEDLINE | ID: mdl-25892812

RESUMEN

The purpose of this study was to evaluate the effect of soaking in noni juice on the microbiological and color behavior of minimally processed mango. Two batches of Haden mango cubes were treated by immersion in noni juice for 2.5 or 5.0 min. Each batch was packed in polypropylene boxes and stored at 6 °C for up to 15 days; in addition, a control group of mango cubes was prepared by immersion in sterile water for the same duration. According to the results, the soaking of mango cubes in noni juice had an antimicrobial effect on mesophilic aerobic bacteria, molds and yeasts during storage at 6 °C for 15 days, without significantly (P < 0.05) affecting the CIE L*, a*, b*, chroma and hue angle values, in comparison with the control after 12 days of storage. The noni juice soaking treatment was demonstrated to be a potentially valuable technology for decontamination of fresh-cut fruit surfaces.

10.
Magn Reson Med ; 71(5): 1854-62, 2014 May.
Artículo en Inglés | MEDLINE | ID: mdl-23798369

RESUMEN

PURPOSE: There is a clinical need for noninvasive, nonionizing imaging biomarkers of tumor hypoxia and oxygenation. We evaluated the relationship of T1 -weighted oxygen-enhanced magnetic resonance imaging (OE-MRI) measurements to histopathology measurements of tumor hypoxia in a murine glioma xenograft and demonstrated technique translation in human glioblastoma multiforme. METHODS: Preclinical evaluation was performed in a subcutaneous murine human glioma xenograft (U87MG). Animals underwent OE-MRI followed by dynamic contrast-enhanced MRI (DCE-MRI) and histological measurement including reduced pimonidazole adducts and CD31 staining. Area under the curve (AUC) was measured for the R1 curve for OE-MRI and the gadolinium concentration curve for DCE-MRI. Clinical evaluation in five patients used analogous imaging protocols and analyses. RESULTS: Changes in AUC of OE-MRI (AUCOE ) signal were regionally heterogeneous across all U87MG tumors. Tumor regions with negative AUCOE typically had low DCE-MRI perfusion, had positive correlation with hypoxic area (P = 0.029), and had negative correlation with vessel density (P = 0.004). DCE-MRI measurements did not relate to either hypoxia or vessel density in U87MG tumors. Clinical data confirmed comparable signal changes in patients with glioblastoma. CONCLUSION: These data support further investigation of T1 -weighted OE-MRI to identify regional tumor hypoxia. The quantification of AUCOE has translational potential as a clinical biomarker of hypoxia.


Asunto(s)
Neoplasias Encefálicas/metabolismo , Glioblastoma/metabolismo , Glioma/metabolismo , Imagen por Resonancia Magnética/métodos , Oximetría/métodos , Oxígeno/metabolismo , Animales , Biomarcadores de Tumor/metabolismo , Neoplasias Encefálicas/patología , Hipoxia de la Célula , Línea Celular Tumoral , Femenino , Glioblastoma/patología , Glioma/patología , Humanos , Ratones , Ratones Desnudos , Reproducibilidad de los Resultados , Sensibilidad y Especificidad , Distribución Tisular
11.
Emotion ; 2024 Sep 30.
Artículo en Inglés | MEDLINE | ID: mdl-39347743

RESUMEN

Navigating our social environment requires the ability to distinguish ourselves from others. Previous research suggests that training interventions have the potential to enhance the capacity for self-other distinction (SOD), which then may impact various sociocognitive domains, including imitation-inhibition, visual perspective taking, and empathy. Importantly, empirical research on the role of SOD in emotion regulation remains scarce. In this study, we aim to investigate the impact of training SOD on emotion regulation and also replicate findings on empathy and the attribution of mental states to others. Using a pre-post design, participants (N = 104) were assigned to either the imitation-inhibition or general inhibitory control training. Compared to general inhibitory control training, participants trained to inhibit imitation displayed a significant increase in posttest emotion regulation levels compared to pretest levels, indicating that imitation-inhibition training increased self-reported emotion regulation. Notably, emotional interference remained unaffected by either form of training. Both training interventions resulted in diminished self-reported empathic concern, while only general inhibitory control training led to a reduction in personal distress. Moreover, neither type of training had an impact on self-reported perspective taking or theory of mind performance. This study provides novel empirical evidence of the positive impact of imitation-inhibition training on emotion regulation. Furthermore, our findings make significant contributions to the advancement of research in this area and offer further support for the advantages of behavioral training as a methodological approach to studying sociocognitive abilities. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

12.
Gels ; 10(8)2024 Jul 31.
Artículo en Inglés | MEDLINE | ID: mdl-39195033

RESUMEN

Herein, we investigated hydrogels composed of boronic-acid-functionalized alginate and blended with polyvinyl alcohol (PVA) of different molecular weights to control the release of metoclopramide hydrochloride as a function of pH and shear stress. The functionalization of alginate introduced dynamic covalent bonding and pH-responsive properties that can modulate network connectivity. The study investigated the viscoelastic properties of the hydrogels, their drug release profiles, and their responsiveness to changes in pH and shear forces. The results showed that a higher PVA molecular weight and alkaline pH conditions increased hydrogel viscosity and stiffness due to a more stable and interconnected network structure than acidic pH. Metoclopramide release revealed that the hydrogels exhibited pH-responsive drug release behavior. The drug was more readily released under acidic conditions due to the instability of sp2-hybridized boronate ester bonds. The influence of shear forces on the release of metoclopramide was also investigated at shear rates of 1, 10, and 100 s-1, revealing their effect on matrix stiffening. Research shows that AlgBA/PVA hydrogels have unique properties, such as dynamic covalent bonding, that make them sensitive to external mechanical forces. This sensitivity makes them ideal for applications where physiological conditions trigger drug release.

13.
Heliyon ; 10(11): e32225, 2024 Jun 15.
Artículo en Inglés | MEDLINE | ID: mdl-38868042

RESUMEN

The impact of high-intensity ultrasound (HIU, 20 kHz) on the physicochemical and functional characteristics of gourd seed protein isolate (GoSPI) was studied. GoSPI was prepared from oil-free gourd seed flour through alkaline extraction (pH 11) and subsequent isoelectric precipitation (pH 4). The crude protein concentration of GoSPI ranged from 91.56 ± 0.17 % to 95.43 ± 0.18 %. Aqueous suspensions of GoSPI (1:3.5 w/v) were ultrasonicated at powers of 200, 400, and 600 W for 15 and 30 min. Glutelins (76.18 ± 0.15 %) were the major protein fraction in GoSPI. HIU decreased the moisture, ash, ether extract, and nitrogen-free extract contents and the hue angle, available water and a* and b* color parameters of the GoSPI in some treatments. The L* color parameter increased (7.70 %) after ultrasonication. HIU reduced the bulk density (52.63 %) and particle diameter (39.45 %), as confirmed by scanning electron microscopy, indicating that ultrasonication dissociated macromolecular aggregates in GoSPI. These structural changes enhanced the oil retention capacity and foam stability by up to 62.60 and 6.84 %, respectively, while the increases in the solvability, water retention capacity, and emulsifying activity index of GoSPI were 90.10, 19.80, and 43.34 %, respectively. The gelation, foaming capacity, and stability index of the emulsion showed no improvement due to HIU. HIU altered the secondary structure of GoSPI by decreasing the content of α-helices (49.66 %) and increasing the content of ß-sheets (52.00 %) and ß-turns (65.00 %). The electrophoretic profile of the GoSPI was not changed by HIU. The ultrasonicated GoSPI had greater functional attributes than those of the control GoSPI and could therefore be used as a functional food component.

14.
Ultrason Sonochem ; 105: 106870, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38579570

RESUMEN

The obtained seeds from fruit processing are considered by-products containing proteins that could be utilized as ingredients in food manufacturing. However, in the specific case of soursop seeds, their usage for the preparation of protein isolates is limited. In this investigation a protein isolate from soursop seeds (SSPI) was obtained by alkaline extraction and isoelectric precipitation methods. The SSPI was sonicated at 200, 400 and 600 W during 15 and 30 min and its effect on the physicochemical, functional, biochemical, and structural properties was evaluated. Ultrasound increased (p < 0.05) up to 5 % protein content, 261 % protein solubility, 60.7 % foaming capacity, 30.2 % foaming stability, 86 % emulsifying activity index, 4.1 % emulsifying stability index, 85.4 % in vitro protein digestibility, 423.4 % albumin content, 83 % total sulfhydryl content, 316 % free sulfhydryl content, 236 % α-helix, 46 % ß-sheet, and 43 % ß-turn of SSPI, in comparison with the control treatment without ultrasound. Furthermore, ultrasound decreased (p < 0.05) up to 50 % particle size, 37 % molecular flexibility, 68 % surface hydrophobicity, 41 % intrinsic florescence spectrum, and 60 % random coil content. Scanning electron microscopy analysis revealed smooth structures of the SSPI with molecular weights ranging from 12 kDa to 65 kDa. The increase of albumins content in the SSPI by ultrasound was highly correlated (r = 0.962; p < 0.01) with the protein solubility. Improving the physicochemical, functional, biochemical and structural properties of SSPI by ultrasound could contribute to its utilization as ingredient in food industry.


Asunto(s)
Annona , Proteínas de Plantas , Semillas , Solubilidad , Semillas/química , Proteínas de Plantas/química , Proteínas de Plantas/aislamiento & purificación , Annona/química , Ondas Ultrasónicas , Fenómenos Químicos , Sonicación
15.
Nat Commun ; 15(1): 7889, 2024 Sep 10.
Artículo en Inglés | MEDLINE | ID: mdl-39256386

RESUMEN

Lithium salt-doped spiro-OMeTAD is widely used as a hole-transport layer (HTL) for high-efficiency n-i-p perovskite solar cells (PSCs), but unfortunately facing awkward instability for commercialization arising from the intrinsic Li+ migration and hygroscopicity. We herein demonstrate a superoxide radicals (•O2-) derived HTL of metal-free spiro-OMeTAD with remarkable capability of avoiding the conventional tedious oxidation treatment in air for highly stable PSCs. Present work explores the employing of variant-valence Eu(TFSI)2 salts that could generate •O2- for facile and adequate pre-oxidation of spiro-OMeTAD, resulting in the HTL with dramatically increased conductivity and work function. Comparing to devices adopting HTL with LiTFSI doping, the •O2--derived spiro-OMeTAD increases the PSCs efficiency up to 25.45% and 20.76% for 0.05 cm2 active area and 6 × 6 cm2 module, respectively. State-of-art PSCs employing such metal-free HTLs are also demonstrated to show much-improved environmental stability even under harsh conditions, e.g., maintaining over 90% of their initial efficiency after 1000 h of operation at the maximum power point and after 80 light-thermal cycles under simulated low earth orbit conditions, respectively, indicating the potentials of developing metal-free spiro-OMeTAD for low-cost and shortened processing of perovskite photovoltaics.

16.
NMR Biomed ; 26(10): 1258-70, 2013 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-23564602

RESUMEN

Drug-induced liver injury (DILI) is a clinically important adverse drug reaction, which prevents the development of many otherwise safe and effective new drugs. Currently, there is a lack of sensitive and specific biomarkers that can be used to predict, assess and manage this toxicity. The aim of this work was to evaluate gadoxetate-enhanced MRI as a potential novel biomarker of hepatobiliary transporter inhibition in the rat. Initially, the volume fraction of extracellular space in the liver was determined using gadopentetate to enable an estimation of the gadoxetate concentration in hepatocytes. Using this information, a compartmental model was developed to characterise the pharmacokinetics of hepatic uptake and biliary excretion of gadoxetate. Subsequently, we explored the impact of an investigational hepatobiliary transporter inhibitor on the parameters of the model in vivo in rats. The investigational hepatobiliary transporter inhibitor reduced both the rate of uptake of gadoxetate into the hepatocyte, k1 , and the Michaelis-Menten constant, Vmax , characterising its excretion into bile, whereas KM values for biliary efflux were increased. These effects were dose dependent and correlated with effects on plasma chemistry markers of liver dysfunction, in particular bilirubin and bile acids. These results indicate that gadoxetate-enhanced MRI provides a novel functional biomarker of inhibition of transporter-mediated hepatic uptake and clearance in the rat. Since gadoxetate is used clinically, the technology has the potential to provide a translatable biomarker of drug-induced perturbation of hepatic transporters that may also be useful in humans to explore deleterious functional alterations caused by transporter inhibition.


Asunto(s)
Sistema Biliar/metabolismo , Biomarcadores/metabolismo , Medios de Contraste , Gadolinio DTPA , Hígado/metabolismo , Imagen por Resonancia Magnética , Proteínas de Transporte de Membrana/metabolismo , Miembro 11 de la Subfamilia B de Transportador de Casetes de Unión al ATP , Transportadoras de Casetes de Unión a ATP/antagonistas & inhibidores , Transportadoras de Casetes de Unión a ATP/metabolismo , Animales , Transporte Biológico , Espacio Extracelular/metabolismo , Gadolinio DTPA/farmacocinética , Células HEK293 , Hepatocitos/metabolismo , Humanos , Transportador 1 de Anión Orgánico Específico del Hígado , Masculino , Proteína 2 Asociada a Resistencia a Múltiples Medicamentos , Proteínas Asociadas a Resistencia a Múltiples Medicamentos/antagonistas & inhibidores , Proteínas Asociadas a Resistencia a Múltiples Medicamentos/metabolismo , Transportadores de Anión Orgánico/antagonistas & inhibidores , Transportadores de Anión Orgánico/metabolismo , Ratas , Ratas Wistar
17.
Acta Psychol (Amst) ; 240: 104056, 2023 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-37865000

RESUMEN

Past research has yielded conflicting findings concerning socio-cognitive deficits in individuals with autistic traits. This raises the fundamental question whether autistic traits and socio-cognitive abilities are related. The present study investigated whether three key socio-cognitive abilities-imitation-inhibition, empathy, and emotion regulation-can serve as predictive factors for autistic traits within a neurotypical population. Participants (N = 166, Mage = 24.83 years, SDage = 5.20 years, rangeage = 18 to 39 years) were asked to perform an online imitation-inhibition task and complete self-report measures assessing empathy, emotion regulation, and autistic traits. Empathy was measured using the Interpersonal Reactivity Index (IRI), emotion regulation was assessed using the Difficulties in Emotion Regulation Scale (DERS), and autistic traits were measured using the ten-item short form of the Autism-Spectrum Quotient (AQ-10). Multiple regression analyses revealed that both imitation-inhibition and emotion regulation were significantly associated with autistic traits. However, empathy was not found to be a significant predictor. Our study aimed to clarify inconsistent results regarding the relationship between socio-cognitive abilities and autistic traits.


Asunto(s)
Trastorno Autístico , Humanos , Adulto Joven , Adulto , Preescolar , Adolescente , Trastorno Autístico/psicología , Cognición Social , Empatía , Cognición
18.
Eur J Psychotraumatol ; 14(2): 2263313, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37815059

RESUMEN

BACKGROUND: ICD-11 Posttraumatic Stress Disorder (PTSD) and Complex PTSD (CPTSD) are stress-related disorders. The International Trauma Questionnaire (ITQ) is a widely used instrument to assess PTSD and CPTSD. To date, there is no evidence of the psychometric characteristics of the ITQ in Latin American countries. OBJECTIVE: The aim of this study was to assess the construct and concurrent validity of the Latin American Spanish adaptation of the ITQ in a sample of Chilean adults. METHODS: A sample of 275 Chilean young adults completed the ITQ, a traumatic life events checklist, the Adverse Childhood Experiences Questionnaire, the Depression Anxiety Stress Scales-21, and the Columbia-Suicide Severity Rating Scale short version. Four alternative confirmatory factor analysis models were tested. Correlation analyses were performed to determine concurrent validity with associated measures (number of reported traumatic events, number of adverse childhood experiences, anxiety, depression, and suicidal risk). RESULTS: The second-order two-factor (PTSD and DSO) and the correlated first-order six-factor model provided acceptable fit; however, the first model showed a better fit based on the BIC difference. The PTSD and DSO dimensions, as well as the six ITQ clusters showed positive correlations with reported number of traumatic life-events, reported number of adverse childhood experiences, levels of anxiety, depression, and suicidal risk. CONCLUSIONS: The ITQ Latin American Spanish adaptation provides acceptable psychometric evidence to assess PTSD and CPTSD in accordance with the ICD-11.


This study is an initial validation of the Latin American Spanish adaptation of the ITQ with a Chilean young adults sample.The latent structure of the Latin American Spanish ITQ was better supported by a two-factor second-order model (PTSD/DSO); a six-factor correlated model was also acceptable.The six ITQ symptom clusters, as well as the PTSD/CPTSD dimensions were significantly positively correlated with three criterion variables: anxiety, depression, and suicidal risk.The number of potentially traumatic experiences, as well as number of exposure to adverse childhood experiences, was significantly associated with PTSD/CPTSD symptoms.


Asunto(s)
Trastornos por Estrés Postraumático , Adulto Joven , Humanos , Chile , Trastornos por Estrés Postraumático/diagnóstico , Trastornos por Estrés Postraumático/epidemiología , Encuestas y Cuestionarios , Ansiedad/diagnóstico , Trastornos de Ansiedad
19.
Nanomaterials (Basel) ; 13(5)2023 Feb 22.
Artículo en Inglés | MEDLINE | ID: mdl-36903684

RESUMEN

For optoelectronic devices from the near to the far infrared, the advantages of using ultrathin III-Sb layers as quantum wells or in superlattices are well known. However, these alloys suffer from severe surface segregation problems, so that the actual profiles are very different from the nominal ones. Here, by inserting AlAs markers within the structure, state-of-the-art transmission electron microscopy techniques were used to precisely monitor the incorporation/segregation of Sb in ultrathin GaAsSb films (from 1 to 20 monolayers (MLs)). Our rigorous analysis allows us to apply the most successful model for describing the segregation of III-Sb alloys (three-layer kinetic model) in an unprecedented way, limiting the number of parameters to be fitted. The simulation results show that the segregation energy is not constant throughout the growth (which is not considered in any segregation model) but has an exponential decay from 0.18 eV to converge asymptotically towards 0.05 eV. This explains why the Sb profiles follow a sigmoidal growth model curve with an initial lag in Sb incorporation of 5 MLs and would be consistent with a progressive change in surface reconstruction as the floating layer is enriched.

20.
Nanomaterials (Basel) ; 12(22)2022 Nov 16.
Artículo en Inglés | MEDLINE | ID: mdl-36432312

RESUMEN

A series of six polybenzylic dendrons with an alkynyl focal point were synthesized for their incorporation to gold nanoparticles. Five of these compounds showed columnar mesomorphism in a wide range of temperatures. These dendrons were reacted with gold nanoparticles stabilized with a combination of a dodecanethiol and 11-azidoundecane-1-thiol. The azido group of the last compound allowed the functionalization of the nanoparticles with the six polybenzylic dendrons by 1,3-dipolar cycloaddition between their alkynyl groups and the terminal azido groups of the thiols. A high efficiency of the cycloaddition process (47-69%) was confirmed by several experimental techniques and no decomposition or aggregation phenomena were detected in the dendron-coated nanoparticles. The involved mechanism and the resulting percentage composition of the final materials are discussed. The results of the ulterior growth of the nanoparticles by thermal treatment are influenced by the size and the shape of the dendron and the temperature of the process. The structures of the final nanoparticles were investigated by TEM, DSC, TGA, NMR and UV-Vis spectroscopy. These nanoparticles do not show liquid crystal properties. However, a melting process between a crystalline and a fluid phase is observed. In the solid phase, the nanomaterials prepared show a short-range interaction between nanoparticles with a 2D local hexagonal order. A near-field effect was observed in the UV-vis spectra by coupling of different surface plasmon resonance bands (SPR) probably due to the short-range interactions. The main novelty of this work lies in the scarcity of previous studies of gold nanoparticles coated with dendrons forming themselves columnar mesophases. Most of the studies reported in the literature deal with gold nanoparticles coated with calamitic mesogens. Additionally, the effect of the thermal treatment, which in a previous paper was shown to increase the mean size of the nanoparticles without increasing their size polydispersity, has been studied in these materials.

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