RESUMEN
OBJECTIVE: Lipoprotein (a) [Lp (a)] is an atherogenic particle that structurally resembles a low-density lipoprotein (LDL) particle but contains a molecule of apolipoprotein (a) attached to apolipoprotein B-100 by a disulfide bond. Because of the fact that elevated plasma levels of Lp (a) have been shown to be an independent risk factor for coronary artery disease (CAD), we determined plasma Lp(a) levels in CAD for Turkish population, and compared them with previous findings of some developed countries. RESULTS: The mean plasma Lp (a) levels in CAD group (mean +/- SD; 0.41 +/- 0.21, g/L) was found approximately twofold higher than that of the control group (0.21 +/- 0.17 g/L). Also, it was found to be higher than the mean levels of CAD group in the other populations described in previous reports. But CAD prevalence in the Turkish population is lower than in those of developed countries, especially the United States. CONCLUSIONS: We concluded that the interaction between plasma Lp (a) levels and many other factors such as face and heredity affecting development of CAD may show different effects for development of CAD in each of those populations separately.
Asunto(s)
Enfermedad Coronaria/sangre , Lipoproteína(a)/sangre , Anciano , Estudios de Casos y Controles , Estudios de Evaluación como Asunto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Factores de Riesgo , TurquíaRESUMEN
Serum lipoprotein (a) [Lp (a)] concentrations are highly skewed in different populations. We measured serum Lp (a) by quantitative enzyme-linked immunosorbent assay (ELISA) in 248 healthy Turkish subjects (127 male, 121 female). The mean Lp (a) value was 0.21 g/L and values did not differ between the sexes. The Lp (a) frequency distribution showed less skewness than those of Asian and Western populations but it clearly deviated from a Gaussian distribution. Plasma Lp (a) concentration did not correlate significantly with age, total cholesterol, low-density lipoprotein (LDL)-cholesterol, high-density lipoprotein (HDL)-cholesterol, apolipoprotein A-1 and B or triglyceride concentration.