Detalles de la búsqueda
1.
Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy.
Br J Cancer
; 116(9): 1166-1176, 2017 Apr 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-28334731
2.
A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.
Nat Chem Biol
; 11(12): 973-980, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26502155
3.
Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition.
Proc Natl Acad Sci U S A
; 109(20): E1267-76, 2012 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22529373
4.
Circulating microRNA Analysis in a Prospective Co-clinical Trial Identifies MIR652-3p as a Response Biomarker and Driver of Regorafenib Resistance Mechanisms in Colorectal Cancer.
Clin Cancer Res
; 30(10): 2140-2159, 2024 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38376926
5.
Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones.
J Med Chem
; 66(8): 5892-5906, 2023 04 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-37026591
6.
FGF7-FGFR2 autocrine signaling increases growth and chemoresistance of fusion-positive rhabdomyosarcomas.
Mol Oncol
; 16(6): 1272-1289, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34850536
7.
Identification of ovarian high-grade serous carcinoma cell lines that show estrogen-sensitive growth as xenografts in immunocompromised mice.
Sci Rep
; 10(1): 10799, 2020 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32612269
8.
Quizartinib-resistant FLT3-ITD acute myeloid leukemia cells are sensitive to the FLT3-Aurora kinase inhibitor CCT241736.
Blood Adv
; 4(7): 1478-1491, 2020 04 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-32282883
9.
De novo phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy.
Autophagy
; 16(6): 1044-1060, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-31517566
10.
Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma.
J Clin Invest
; 130(11): 5875-5892, 2020 11 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33016930
11.
Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.
Cancer Res
; 67(12): 5840-50, 2007 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17575152
12.
Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer.
Oncogene
; 38(10): 1717-1733, 2019 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30353166
13.
Correction: Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer.
Oncogene
; 38(28): 5746, 2019 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-31147600
14.
ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma.
Commun Biol
; 2: 156, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31098401
15.
An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models.
Cancer Chemother Pharmacol
; 62(5): 769-78, 2008 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-18193424
16.
The Bcl-2/Bcl-XL family inhibitor ABT-737 sensitizes ovarian cancer cells to carboplatin.
Clin Cancer Res
; 13(23): 7191-8, 2007 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18056200
17.
Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity.
Mol Cancer Ther
; 6(12 Pt 1): 3147-57, 2007 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-18089709
18.
Correction to: An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models.
Cancer Chemother Pharmacol
; 82(5): 911-912, 2018 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-30173339
19.
Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-Ethoxy-4-(4-methyl-4 H-1,2,4-triazol-3-yl)phenyl)-6-methyl- N8-neopentylpyrido[3,4- d]pyrimidine-2,8-diamine (BOS172722).
J Med Chem
; 61(18): 8226-8240, 2018 09 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-30199249
20.
Application of meso scale technology for the measurement of phosphoproteins in human tumor xenografts.
Assay Drug Dev Technol
; 5(3): 391-401, 2007 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-17638539