Carnitine palmitoyltransferase 1A promotes mitochondrial fission by enhancing MFF succinylation in ovarian cancer.

Mitochondria are dynamic organelles that are important for cell growth and proliferation. Dysregulated mitochondrial dynamics are highly associated with the initiation and progression of various cancers, including ovarian cancer. However, the regulatory mechanism underlying mitochondrial dynamics is still not fully understood. Previously, our study showed that carnitine palmitoyltransferase 1A (CPT1A) is highly expressed in ovarian cancer cells and promotes the development of ovarian cancer. Here, we find that CPT1A regulates mitochondrial dynamics and promotes mitochondrial fission in ovarian cancer cells. Our study futher shows that CPT1A regulates mitochondrial fission and function through mitochondrial fission factor (MFF) to promote the growth and proliferation of ovarian cancer cells. Mechanistically, we show that CPT1A promotes succinylation of MFF at lysine 302 (K302), which protects against Parkin-mediated ubiquitin-proteasomal degradation of MFF. Finally, the study shows that MFF is highly expressed in ovarian cancer cells and that high MFF expression is associated with poor prognosis in patients with ovarian cancer. MFF inhibition significantly inhibits the progression of ovarian cancer in vivo. Overall, CPT1A regulates mitochondrial dynamics through MFF succinylation to promote the development of ovarian cancer. Moreover, our findings suggest that MFF is a potential therapeutic target for ovarian cancer.

Improved hydrogen evolution performance by engineering bimetallic AuPd loaded on amino and nitrogen functionalized mesoporous hollow carbon spheres.

A highly efficient heterogeneous catalyst was synthesized by delicate engineering of NH2-functionalized and N-doped hollow mesoporous carbon spheres (NH2-N-HMCS), which was used for supporting AuPd alloy nanoparticles with ultrafine size and good dispersion (denoted as AuPd/NH2-N-HMCS). Without using any additives, the prepared AuPd/NH2-N-HMCS catalytic formic acid dehydrogenation possesses superior catalytic activity with an initial turnover frequency value of 7747 mol H2 per mol catalyst per h at 298 K. The excellent performance of AuPd/NH2-N-HMCS derives from the unique hollow mesoporous structure, the small particle sizes and high dispersion of AuPd nanoparticles and the modified Pd electronic structure in the AuPd/NH2-N-HMCS composite, as well as the synergistic effect of the modified support.

Mitogenomic characterization and phylogeny of Scelimena melli Günther (Orthoptera: Tetrigoidea: Scelimeninae).

The mitochondrial genome (mitogenome) of Scelimena melli, which belongs to Orthoptera, Tetrigoidea, Tetrigidae, Scelimeninae was determined. The mitogenome has a length of 14,598 bp and consists of 37 genes including 13 protein-coding genes (PCGs), two rRNA genes, and 22 tRNA genes. Phylogenetic analysis using 37 mitochondrial genes with other 22 Tetrigoidea species revealed that S. melli had a closer relationship with Paragavialidium sichuanense, but the monophyly of Scelimeninae was not recovered. The mitogenome data of S. melli would provide useful resources for further evolutionary studies of Scelimeninae and Tetrigoidea species.