1.
Bioorg Med Chem Lett
; 18(17): 4872-5, 2008 Sep 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-18691886
RESUMEN
Relationships between physicochemical drug properties and toxicity were inferred from a data set consisting of animal in vivo toleration (IVT) studies on 245 preclinical Pfizer compounds; an increased likelihood of toxic events was found for less polar, more lipophilic compounds. This trend held across a wide range of types of toxicity and across a broad swath of chemical space.