RESUMEN
Retinoid X Receptor beta (RXRB) is a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). We have confirmed the localization of RXRB to chromosome 6 and we have mapped the gene to chromosome 6p21.3-p21.1 by PCR amplification of 5' untranslated sequence in panels of rodent-human somatic cell hybrids and to 6p21.3 by fluorescent in situ hybridization.
Asunto(s)
Cromosomas Humanos Par 6 , Receptores Citoplasmáticos y Nucleares/genética , Receptores de Ácido Retinoico , Factores de Transcripción , Animales , Secuencia de Bases , Mapeo Cromosómico , ADN/genética , ADN/aislamiento & purificación , Cartilla de ADN , Humanos , Células Híbridas , Hibridación Fluorescente in Situ , Cariotipificación , Datos de Secuencia Molecular , Reacción en Cadena de la Polimerasa/métodos , Receptores X Retinoide , Retinoides/metabolismo , RoedoresRESUMEN
The retinoid X receptor alpha is one of a number of retinoic acid receptors which are members of the steroid/thyroid hormone superfamily. Localization of RXRA was achieved using the polymerase chain reaction on a panel of somatic cell hybrids. A cosmid clone was isolated using the RXRA PCR product, and this was used to further localize the gene by fluorescence in situ hybridization to chromosome 9q34 distal to the dopamine beta hydroxylase gene (DBH). This mapping position was confirmed by PCR on a panel of translocation hybrids.