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The gut microbiome has been regarded as one of the fundamental determinants regulating human health, and multi-omics data profiling has been increasingly utilized to bolster the deep understanding of this complex system. However, stemming from cost or other constraints, the integration of multi-omics often suffers from incomplete views, which poses a great challenge for the comprehensive analysis. In this work, a novel deep model named Incomplete Multi-Omics Variational Neural Networks (IMOVNN) is proposed for incomplete data integration, disease prediction application and biomarker identification. Benefiting from the information bottleneck and the marginal-to-joint distribution integration mechanism, the IMOVNN can learn the marginal latent representation of each individual omics and the joint latent representation for better disease prediction. Moreover, owing to the feature-selective layer predicated upon the concrete distribution, the model is interpretable and can identify the most relevant features. Experiments on inflammatory bowel disease multi-omics datasets demonstrate that our method outperforms several state-of-the-art methods for disease prediction. In addition, IMOVNN has identified significant biomarkers from multi-omics data sources.
Asunto(s)
Microbioma Gastrointestinal , Enfermedades Inflamatorias del Intestino , Humanos , Multiómica , Biomarcadores , Enfermedades Inflamatorias del Intestino/genética , Redes Neurales de la ComputaciónRESUMEN
For decades, soft sensors have been extensively renowned for their efficiency in real-time tracking of expensive variables for advanced process control. However, despite the diverse efforts lavished on enhancing their models, the issue of label sparsity when modeling the soft sensors has always posed challenges across various processes. In this paper, a fledgling technique, called co-training, is studied for leveraging only a small ratio of labeled data, to hone and formulate a more advantageous framework in soft sensor modeling. Dissimilar to the conventional routine where only two players are employed, we investigate the efficient number of players in batch processes, making a multiple-player learning scheme to assuage the sparsity issue. Meanwhile, a sliding window spanning across both time and batch direction is used to aggregate the samples for prediction, and account for the unique 2D correlations among the general batch process data. Altogether, the forged framework can outperform the other prevalent methods, especially when the ratio of unlabeled data is climbing up, and two case studies are showcased to demonstrate its effectiveness.
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From the perspective of philosophy, ontology relations denote ultimate semantic relations of related knowledge concepts. Beyond doubt, it is still a very difficult problem on how to automatically depict and construct ontology relations because of its high abstractness. Some latest research attempted to realize ontology relation learning by learning abstract hierarchies or similarities among knowledge concepts. Inspired by the requirements of associative semantic cognition like in the human brain, a constructivist ontology relation learning (CORL) method is put forward in this study by borrowing the idea of the constructivist learning theory. Wherein, two following points are supposed: 1) each symbol knowledge is looked as a token of representing certain abstract pattern and 2) each pattern denotes a type of relation structures on other patterns, or a directly observed event data, such as physical sensing data, natural image, sound data, text word etc. So, ontology relation could be considered as the associative support degrees from other knowledge concepts to the target concept, which reflects how one knowledge ontology can be demarcated by other knowledge concepts. Then, the knowledge network can be employed to represent an entire domain knowledge system. Meanwhile, an associative random walk mechanism (ARWM) on knowledge network can be considered to explain the semantic generative process of every document. Thus, CORL can be realized by integrating ARWM into an extended latent Dirichlet allocation (LDA) model. Some theoretical and experimental analysis are done. The corresponding results demonstrate that CORL can obtain effective associative semantic relations among concept words, and gain some novel characteristics in better representing knowledge ontology than existing methods.
Asunto(s)
Aprendizaje , Semántica , Cognición , HumanosRESUMEN
A novel mononuclear zinc complex [ZnL(Phen)(H2O)]·H2O containing the mixed ligands of Phen (Phen = 1,10-phenanthroline) and 3-hydroxy-2-methylquinoline-4-carboxylic acid (HL) was prepared by hydrothermal synthesis and its crystal structure was characterized by X-ray single-crystal diffraction method. The title complex crystallizes in the orthorhombic systems and forms monomeric units. The molecules in the title complex are connected through the interactions of hydrogen-bonding and ????? interactions to give a three-dimensional (3D) supramolecular structure. The fluorescence result discovers a wide emission band in the violet blue region. Time-dependent density functional theory (TDDFT) calculations reveal that this emission can be attributed to ligand-to-ligand charge transfer (LLCT). Solid-state diffuse reflectance shows there is a wide optical band gap.
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Network embedding (NE), which maps nodes into a low-dimensional latent Euclidean space to represent effective features of each node in the network, has obtained considerable attention in recent years. Many popular NE methods, such as DeepWalk, Node2vec, and LINE, are capable of handling homogeneous networks. However, nodes are always fully accompanied by heterogeneous information (e.g., text descriptions, node properties, and hashtags) in the real-world network, which remains a great challenge to jointly project the topological structure and different types of information into the fixed-dimensional embedding space due to heterogeneity. Besides, in the unweighted network, how to quantify the strength of edges (tightness of connections between nodes) accurately is also a difficulty faced by existing methods. To bridge the gap, in this paper, we propose CAHNE (context attention heterogeneous network embedding), a novel network embedding method, to accurately determine the learning result. Specifically, we propose the concept of node importance to measure the strength of edges, which can better preserve the context relations of a node in unweighted networks. Moreover, text information is a widely ubiquitous feature in real-world networks, e.g., online social networks and citation networks. On account of the sophisticated interactions between the network structure and text features of nodes, CAHNE learns context embeddings for nodes by introducing the context node sequence, and the attention mechanism is also integrated into our model to better reflect the impact of context nodes on the current node. To corroborate the efficacy of CAHNE, we apply our method and various baseline methods on several real-world datasets. The experimental results show that CAHNE achieves higher quality compared to a number of state-of-the-art network embedding methods on the tasks of network reconstruction, link prediction, node classification, and visualization.