Detalles de la búsqueda
1.
Novel Cytochrome P450 2C119 Enzymes in Cynomolgus and Rhesus Macaques Metabolize Progesterone, Diclofenac, and Omeprazole.
Drug Metab Dispos
; 52(3): 266-273, 2024 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-38123944
2.
Quinuclidine N-oxygenation mediated by flavin-containing monooxygenase (FMO) 1 and FMO3 in kidney and liver microsomes from humans, monkeys, dogs, and pigs.
Drug Metab Dispos
; 2024 May 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-38769015
3.
Novel Tree Shrew Cytochrome P450 2Ds (CYP2D8a and CYP2D8b) Are Functional Drug-Metabolizing Enzymes that Metabolize Bufuralol and Dextromethorphan.
Drug Metab Dispos
; 52(4): 305-311, 2024 Mar 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-38262704
4.
In Vivo and In Vitro Induction of Cytochrome P450 3A4 by Thalidomide in Humanized-Liver Mice and Experimental Human Hepatocyte HepaSH cells.
Chem Res Toxicol
; 37(5): 671-674, 2024 May 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-38626399
5.
Modeled Hepatic/Plasma Exposures of Fluvastatin Prescribed Alone in Subjects with Impaired Cytochrome P450 2C9*3 as One of Possible Determinant Factors Likely Associated with Hepatic Toxicity Reported in a Japanese Adverse Event Database.
Biol Pharm Bull
; 47(3): 635-640, 2024.
Artículo
en Inglés
| MEDLINE | ID: mdl-38494736
6.
Modeled Hepatic/Plasma Exposures of Omeprazole Prescribed Alone in Cytochrome P450 2C19 Poor Metabolizers Are Likely Associated with Hepatic Toxicity Reported in a Japanese Adverse Event Database.
Biol Pharm Bull
; 47(5): 1028-1032, 2024.
Artículo
en Inglés
| MEDLINE | ID: mdl-38797695
7.
HepaSH cells: Experimental human hepatocytes with lesser inter-individual variation and more sustainable availability than primary human hepatocytes.
Biochem Biophys Res Commun
; 663: 132-141, 2023 06 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-37121123
8.
BL09XU: an advanced hard X-ray photoelectron spectroscopy beamline of SPring-8.
J Synchrotron Radiat
; 30(Pt 5): 1013-1022, 2023 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37610343
9.
Species Specificity and Selection of Models for Drug Oxidations Mediated by Polymorphic Human Enzymes.
Drug Metab Dispos
; 51(1): 123-129, 2023 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35772770
10.
A Comprehensive Investigation of Dog Cytochrome P450 3A (CYP3A) Reveals a Functional Role of Newly Identified CYP3A98 in Small Intestine.
Drug Metab Dispos
; 51(1): 38-45, 2023 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35772769
11.
Novel Cytochrome P450 2C94 Functionally Metabolizes Diclofenac and Omeprazole in Dogs.
Drug Metab Dispos
; 51(5): 637-644, 2023 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36754837
12.
The Unique Human N10-Glucuronidated Metabolite Formation from Olanzapine in Chimeric NOG-TKm30 Mice with Humanized Livers.
Drug Metab Dispos
; 51(4): 480-491, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36623885
13.
Variants of Flavin-Containing Monooxygenase 3 Found in Subjects in an Updated Database of Genome Resources.
Drug Metab Dispos
; 51(7): 884-891, 2023 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-37041084
14.
Newly Identified Tree Shrew Cytochrome P450 2A13 is Expressed in Liver and Lung and Encodes a Functional Drug-Metabolizing Enzyme Similar to Dog Cytochrome P450 2A13 and Pig Cytochrome P450 2A19.
Drug Metab Dispos
; 51(5): 610-617, 2023 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36669854
15.
Pharmacokinetic Models Scaled-up from Humanized-liver Mouse Data Can Account for Drug Monitoring Results of Atomoxetine and Its 4-Hydroxylated and N-Demethylated Metabolites i n Pediatric Patients Genotyped for Cytochrome P450 2D6.
Drug Metab Dispos
; 2023 Oct 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-37879849
16.
Oxidation of Naringenin, Apigenin, and Genistein by Human Family 1 Cytochrome P450 Enzymes and Comparison of Interaction of Apigenin with Human P450 1B1.1 and Scutellaria P450 82D.1.
Chem Res Toxicol
; 36(11): 1778-1788, 2023 11 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-37783573
17.
Modeled Rat Hepatic and Plasma Concentrations of Chemicals after Virtual Administrations Using Two Sets of in Silico Liver-to-Plasma Partition Coefficients.
Biol Pharm Bull
; 46(9): 1316-1323, 2023 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37380443
18.
Liver and Plasma Concentrations of Food Chemicals after Virtual Oral Doses Extrapolated Using in Silico Estimated Input Pharmacokinetic Parameters to Confirm Reported Liver Toxicity in Rats.
Biol Pharm Bull
; 46(8): 1133-1140, 2023 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37316265
19.
Plasma and Hepatic Exposures of Celecoxib and Diclofenac Prescribed Alone in Patients with Cytochrome P450 2C9*3 Modeled after Virtual Oral Administrations and Likely Associated with Adverse Drug Events Reported in a Japanese Database.
Biol Pharm Bull
; 46(6): 856-863, 2023 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37062721
20.
2-Oxidation, 3-methyl hydroxylation, and 6-hydroxylation of skatole, a contributor to the odour of boar-tainted pork meat, mediated by porcine liver microsomal cytochromes P450 1A2, 2A19, 2E1, and 3A22.
Xenobiotica
; 53(1): 60-65, 2023 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-36976910