RESUMEN
A considerable incidence of colonic strictures after oncologic low anterior resections has been reported. The present paper describes a colonic stricture 5 years after the surgery, and not related to radiotherapy, that required a challenging differential diagnosis with local recurrence of rectal cancer. The role of endoscopy in the management of this condition is discussed.
Asunto(s)
Colitis Isquémica/complicaciones , Enfermedades del Colon/diagnóstico , Enfermedades del Colon/etiología , Obstrucción Intestinal/diagnóstico , Obstrucción Intestinal/etiología , Complicaciones Posoperatorias/diagnóstico , Complicaciones Posoperatorias/etiología , Recto/cirugía , Anciano , Humanos , Masculino , Factores de TiempoRESUMEN
BACKGROUND: The growing popularity in western countries of eating uncooked seafood has resulted in an increased incidence of anisakidosis. AIM: To study the in vitro activity of different concentrations of albendazole against Anisakis simplex larvae under different media pH. METHODS: A. simplex larvae were obtained from fresh hakes acquired from the fish market of Madrid. They were divided into groups and placed in culture dishes (15 larvae each) containing RPMI-1640, in the presence or absence of different concentrations of albendazole (300, 400 and 500 microg/mL). RESULTS: Albendazole dose-dependently reduced the survival of the larvae, its maximum activity being at 500 microg/mL when it killed almost all larvae at 48 h. Acidic medium pH significantly reduced the efficacy of albendazole. CONCLUSION: Albendazole is effective in killing A. simplex larvae at different pH in vitro, suggesting that this molecule could be useful in treating clinical manifestations of human anisakidosis.
Asunto(s)
Albendazol/farmacología , Anisakis/efectos de los fármacos , Antihelmínticos/farmacología , Albendazol/administración & dosificación , Animales , Antihelmínticos/administración & dosificación , Relación Dosis-Respuesta a Droga , Concentración de Iones de HidrógenoRESUMEN
The malignancy risk in Crohn's disease is less than that of ulcerative colitis, although it has not been so well studied. The possibility of an early detection of malignant changes during the long term follow-up of the patients induces to look for parameters which might be helpful in this respect. In the second surgical clinic of the Hospital Clinico in Madrid, the pathological findings of 11 patients with the diagnosis of Crohn's disease have been analyzed and correlated with the clinical findings. The evaluation of the degree of dysplasia was done on 15 samples obtained by endoscopy and compared with the findings of the surgical specimens in 6 operated patients. The degree of dysplasia increases with age of the patients and years of evolution of the disease with a significant correlation (p less than 0.001) between negative dysplasia and positive dysplasia grade I.
Asunto(s)
Enfermedad de Crohn/patología , Lesiones Precancerosas , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , RiesgoRESUMEN
Existe una incidencia no despreciable de lesiones de colon deorigen isquémico tras resecciones anteriores bajas por cáncer.Presentamos un caso de estenosis isquémica de colon, no relacionadacon radioterapia, a los 5 años de la cirugía. Se discute la dificultaddel diagnóstico diferencial con recidiva tumoral, así como elimportante papel que desempeña la endoscopia en el abordaje deestos pacientes
A considerable incidence of colonic strictures after oncologiclow anterior resections has been reported. The present paper describesa colonic stricture 5 years after the surgery, and not relatedto radiotherapy, that required a challenging differential diagnosiswith local recurrence of rectal cancer. The role of endoscopyin the management of this condition is discussed