Genetics of leprosy: expected -and unexpected- developments and perspectives
In. Grzybowski, Andrzej; Virmond, Marcos da Cunha Lopes. Clinics in Dermatology: Leprosy: 2. New York, Elsevier, 2016. p.96-104, ilus, tab.
Non-conventional
en En
| SES-SP, HANSEN, HANSENIASE, SESSP-ILSLACERVO, SES-SP
| ID: biblio-1096630
Biblioteca responsable:
BR191.1
Ubicación: BR191.1; 9527/S
ABSTRACT
A solid body of evidence produced over decades of intense research supports the hypothesis that leprosy phenotypes are largely dependent on the genetic characteristics of the host. The early evidence of a major gene effect controlling susceptibility to leprosy came from studies of familial aggregation, twins, and complex segregation analysis. Later, linkage and association analysis, first applied to the investigation of candidate genes and chromosomal regions and more recently, to genome-wide scans, have revealed several HLA and non-HLA gene variants as risk factors for leprosy phenotypes such as disease per se, its clinical forms, and leprosy reactions. In addition, powerful, hypothesis-free strategies such as genome-wide association studies have led to an exciting, unexpected development Leprosy susceptibility genes seem to be shared with Crohn's and Parkinson's disease. Today, a major challenge is to find the exact variants causing the biological effect underlying the genetic associations. New technologies, such as Next Generation Sequencingthat allows, for the first time, the cost- and time-effective sequencing of a complete human genomehold the promise to reveal such variants; thus, strategies can be developed to study the functional impact of these variants in the context of infection, hopefully leading to the development of new targets for leprosy treatment and prevention.
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Banco de datos:
HANSEN
/
HANSENIASE
/
SES-SP
/
SESSP-ILSLACERVO
Asunto principal:
Lepra
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Año:
2016
Tipo del documento:
Non-conventional