Grape juice increases the BDNF levels but not alter the S100B levels in hippocampus and frontal cortex from male Wistar Rats
An. acad. bras. ciênc
; 89(1): 155-161, Jan,-Mar. 2017. tab, graf
Article
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| LILACS
| ID: biblio-886639
Biblioteca responsable:
BR1.1
ABSTRACT
ABSTRACT Several studies have shown that a high consumption of vegetables and fruits is consistently associated with a low risk of oxidative stress-induced diseases, which includes some degenerative diseases such as amyotrophic lateral sclerosis, Alzheimer and Parkinson. Therefore, the objective of this study is to verify the effects of conventional and organic grape juice in the modulation of the neurotrophic factor (BDNF) and astrocytic markers protein (S100B) in hippocampus and frontal cortex of Wistar rats. In this study, 24 male Wistar rats were divided into three groups. To the first one, it was given organic purple grape juice; to the second, conventional grape juice, while the last one received only saline. After 30 days, all rats were sacrificed and hippocampus and frontal cortex were dissected. The animals that received organic and conventional grape juice showed, in frontal cortex, an elevated BNDF levels in relation to saline group. However, S100B levels did not change. These results showed that grape juices are able to modulate important marker in brain tissue, and could be an important factor to prevent brain diseases.
Palabras clave
Texto completo:
1
Banco de datos:
LILACS
Asunto principal:
Factor Neurotrófico Derivado del Encéfalo
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Vitis
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Subunidad beta de la Proteína de Unión al Calcio S100
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Jugos de Frutas y Vegetales
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Lóbulo Frontal
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Hipocampo
Tipo de estudio:
Evaluation_studies
Límite:
Animals
Idioma:
En
Revista:
An. acad. bras. ciênc
Asunto de la revista:
CIENCIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Brasil