The aim of this
work was to study the possible
cardiotoxicity of two different doses of 50 nm nano
titanium dioxide (n-TiO2) and the possible modulating effects of the use of two natural
antioxidants carnosine and
melatonin. The results showed that TiO2- NPs produced deleterious effects on
rat cardiac
tissue as confirmed by the increased levels of
serum myoglobin,
troponin-T and CK-MB. Increased levels of
serum Inflammatory markers represented by the
tumor necrosis factor alpha (TNF-α) and
Interleukin-6 (
IL-6) was also noticed. Caspase3 and
IGg were elevated compared to the
control group in a
dose dependant manner.
treatment of the
rats with
Carnosine or
melatonin. along with TiO2- NPs
administration significantly improved most of the elevated
biochemical markers. It was concluded that the use of
Carnosine or
melatonin could
play a beneficial
role against deleterious effects of TiO2- NPs.