Immunization with the Candida albicans membrane fraction and in combination with fluconazole protects against systemic fungal infections.
Antimicrob Agents Chemother
; 44(2): 243-7, 2000 Feb.
Article
en En
| MEDLINE
| ID: mdl-10639344
ABSTRACT
We studied the immunogenicity of a membrane fraction prepared from Candida albicans cells called C. albicans membrane antigen (CMA). The present study revealed that CMA immunization has antifungal activity in mouse models of systemic fungal infection. Immunization of mice by subcutaneous injections of CMA with incomplete Freund adjuvant induced resistance to infections caused not only by C. albicans but also by Aspergillus fumigatus. The level of resistance to candidiasis was as high as that induced by whole-cell immunization. The acquired resistance to candidiasis in the mice immunized with CMA was not diminished by immunosuppressive treatment with cyclophosphamide. The level of resistance to fungal infections was superior to that given by fluconazole (FLC) treatment alone and highly enhanced by the combination with FLC. When CD4(+) cells in CMA-immunized mice were depleted by a monoclonal antibody, the antifungal activity induced by the combination of CMA and FLC was significantly reduced. These results indicate that immunization with CMA is useful for preventing systemic fungal infections and in combination with FLC for increasing resistance after infection.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Candida albicans
/
Candidiasis
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Fluconazol
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Fungemia
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Antifúngicos
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Antígenos Fúngicos
Límite:
Animals
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2000
Tipo del documento:
Article
País de afiliación:
Japón