Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins.
Neuron
; 25(1): 29-41, 2000 Jan.
Article
en En
| MEDLINE
| ID: mdl-10707970
ABSTRACT
Neuropilins are receptors for class 3 secreted semaphorins, most of which can function as potent repulsive axon guidance cues. We have generated mice with a targeted deletion in the neuropilin-2 (Npn-2) locus. Many Npn-2 mutant mice are viable into adulthood, allowing us to assess the role of Npn-2 in axon guidance events throughout neural development. Npn-2 is required for the organization and fasciculation of several cranial nerves and spinal nerves. In addition, several major fiber tracts in the brains of adult mutant mice are either severely disorganized or missing. Our results show that Npn-2 is a selective receptor for class 3 semaphorins in vivo and that Npn-1 and Npn-2 are required for development of an overlapping but distinct set of CNS and PNS projections.
Buscar en Google
Banco de datos:
MEDLINE
Asunto principal:
Axones
/
Glicoproteínas
/
Proteínas Portadoras
/
Proteínas del Tejido Nervioso
Tipo de estudio:
Guideline
Idioma:
En
Revista:
Neuron
Asunto de la revista:
NEUROLOGIA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos