Lipid peroxidation inhibition in spinal cord injury: cyclosporin-A vs methylprednisolone.
Neuroreport
; 11(8): 1765-7, 2000 Jun 05.
Article
en En
| MEDLINE
| ID: mdl-10852240
ABSTRACT
To compare the effectiveness of cyclosporin-A (CsA) with methylprednisolone (MP) or a combination of both upon inhibition of lipid peroxidation (LP) after spinal cord (SC) injury, rats were treated with either CsA, MP, CSA+MP or vehicle starting 1 h after SC contusion at T9 level. LP was assessed 24h after injury by the lipid fluorescent product formation method. The survival rate was also evaluated in other series of rats by the Kaplan-Meier curves. Lipid peroxidation was similarly inhibited in rats treated with CsA, MP, or CSA+MP (p>0.05). Animals receiving MP (alone or combined with CsA) showed the poorest surviving rate. LP was inhibited by CsA to the same extent as by MP but without the lethal effect of the latter.
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Banco de datos:
MEDLINE
Asunto principal:
Traumatismos de la Médula Espinal
/
Metilprednisolona
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Ciclosporina
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Fármacos Neuroprotectores
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Peróxidos Lipídicos
Límite:
Animals
Idioma:
En
Revista:
Neuroreport
Asunto de la revista:
NEUROLOGIA
Año:
2000
Tipo del documento:
Article