Neurotrophin-3 and neurotrophin receptor immunoreactivity in peptidergic enteric neurons.
Peptides
; 21(9): 1421-6, 2000 Sep.
Article
en En
| MEDLINE
| ID: mdl-11072130
ABSTRACT
In the rat small intestine, neurotrophin-3 immunoreactivity was identified in ganglion cells and in processes mostly innervating the mucosa and occasionally the muscle layer and vasculature. The vast majority of neurotrophin-3 immunoreactive neurons contained vasoactive intestinal polypeptide (VIP), but not substance P or related tachykinin (SP/TK). Neurotrophin receptors visualized by pan-trk immunoreactivity were found in numerous ganglion cells of both plexuses and in nerve processes in the intestinal wall. Pan-trk submucosal neurons contained VIP (36%) or SP/TK-IR (47%). Pan-trk myenteric neurons contained VIP-IR (57%) or SP/TK (27%). Our data suggest that neurotrophin-3 and neurotrophin receptors may be involved in the maintenance of enteric neuronal circuits, transmission and phenotypic expression.
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Banco de datos:
MEDLINE
Asunto principal:
Receptores de Factor de Crecimiento Nervioso
/
Sistema Nervioso Entérico
/
Neurotrofina 3
/
Intestino Delgado
/
Neuronas
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Peptides
Año:
2000
Tipo del documento:
Article
País de afiliación:
Italia