Determination of the disintegration behavior of magnetically marked tablets.

ABSTRACT

The disintegration behavior of different tablets that were marked as magnetic dipoles by the incorporation of ferromagnetic black iron oxide and subsequent magnetization was studied using a specially developed measurement setup. This novel apparatus records the magnetic induction generated by the magnetic dipole moment of the tablets during their disintegration. It was found that the observed decrease of the magnetic induction can be used for a quantitative determination of the disintegration of tablets. In particular, it could be shown that the magnetic data provide information about the disintegration mechanism. For tablets with a minor influence of swelling on the disintegration mechanism a linear decline of the magnetic fluxes was observed. After addition of swelling disintegrants (crospovidone) the decline of the magnetic flux could be fitted by an exponential function, indicating the involvement of a disintegration force. Furthermore, the data demonstrate that using modern multichannel biomagnetic measurement equipment the monitoring of the disintegration behavior of magnetically marked tablets in humans will be possible.