Exclusion of large deletions and other rearrangements in BRCA1 and BRCA2 in Finnish breast and ovarian cancer families.
Cancer Genet Cytogenet
; 129(2): 120-3, 2001 Sep.
Article
en En
| MEDLINE
| ID: mdl-11566341
ABSTRACT
In the Finnish population, identified mutations in BRCA1 and BRCA2 account for a less than expected proportion of hereditary breast and ovarian cancer. All previous studies performed in our country have concentrated on finding germ-line mutations in the coding and splice-site regions of these two genes. Therefore, we wanted to use a different methodological approach and search for large genomic rearrangements, to exclude the possibility of biased BRCA1 and BRCA2 mutation spectra due to known limitations of the previously used PCR-based detection methods. Our results support earlier notions that other genes than BRCA1 and BRCA2 will explain a majority of the still unexplained cases of hereditary susceptibility to breast and ovarian cancer.
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Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Ováricas
/
Factores de Transcripción
/
Neoplasias de la Mama
/
Pruebas Genéticas
/
Eliminación de Secuencia
/
Proteína BRCA1
/
Proteínas de Neoplasias
Tipo de estudio:
Prognostic_studies
Límite:
Female
/
Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
Cancer Genet Cytogenet
Año:
2001
Tipo del documento:
Article
País de afiliación:
Finlandia