Glucocorticoid administration accelerates mortality of pneumovirus-infected mice.
J Infect Dis
; 184(12): 1518-23, 2001 Dec 15.
Article
en En
| MEDLINE
| ID: mdl-11740726
ABSTRACT
The use of glucocorticoids for the treatment of symptoms associated with respiratory syncytial virus (RSV) infection has been questioned. To evaluate the sequelae of glucocorticoid administration in the setting of pneumovirus infection in vivo, hydrocortisone was administered to mice infected with pneumonia virus of mice (PVM), a pneumovirus and natural rodent pathogen that is closely related to RSV and replicates the signs and symptoms of severe human RSV infection. Results showed that hydrocortisone spared the pulmonary neutrophilia but resulted in ablation of the pulmonary eosinophilia, despite continued production of the relevant chemoattractant, macrophage inflammatory protein-1alpha. Hydrocortisone also led to diminished production of inducible nitric oxide synthase and accumulation of reactive nitrogen species in lung tissue and bronchoalveolar lavage fluid and diminished lymphocyte recruitment. PVM-infected mice responded to hydrocortisone with enhanced viral replication and accelerated mortality. These results suggest several mechanisms to explain why glucocorticoid therapy may be of limited benefit in the overall picture of pneumovirus infection.
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Banco de datos:
MEDLINE
Asunto principal:
Neumonía Viral
/
Hidrocortisona
/
Infecciones por Pneumovirus
/
Virus de la Neumonía Murina
/
Antiinflamatorios
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Infect Dis
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos