Autoreactivity against induced or upregulated abundant self-peptides in HLA-A*0201 following measles virus infection.
Hum Immunol
; 64(1): 44-55, 2003 Jan.
Article
en En
| MEDLINE
| ID: mdl-12507814
ABSTRACT
Infectious agents have been implied as causative environmental factors in the development of autoimmunity. However, the exact nature of their involvement remains unknown. We describe a possible mechanism for the activation of autoreactive T cells induced by measles virus (MV) infection. The display of HLA-A*0201 associated peptides obtained from MV infected cells was compared with that from uninfected cells by mass spectrometry. We identified two abundant self peptides, IFI-6-16(74-82) and Hsp90beta(570-578), that were induced or upregulated, respectively, following infection. Their parental proteins, the type I interferon inducible protein IFI-6-16, and the beta chain of heat shock protein 90, have not been involved in MV pathogenesis. MV infection caused minor and major changes in the intracellular expression patterns of these proteins, possibly leading to altered peptide processing. CD8+ T cells capable of recognizing the self-peptides in the context of HLA-A*0201 were detectable at low basal levels in the neonatal and adult human T cell repertoire, but were functionally silent. In contrast, peptide-specific producing IFN-gamma producing effector cells were present in MV patients during acute infection. Thus, MV infection induces an enhanced display of self-peptides in MHC class I, which may lead to the temporary activation of autoreactive T cells.
Buscar en Google
Banco de datos:
MEDLINE
Asunto principal:
Autoantígenos
/
Antígenos HLA-A
/
Sarampión
/
Virus del Sarampión
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Animals
/
Humans
Idioma:
En
Revista:
Hum Immunol
Año:
2003
Tipo del documento:
Article
País de afiliación:
Países Bajos