Effectiveness and tolerability of nimesulide in the treatment of osteoarthritic elderly patients.
Int J Tissue React
; 14(5): 263-8, 1992.
Article
en En
| MEDLINE
| ID: mdl-1300312
One important point in the treatment of osteoarthritis is to control the pain that accompanies the persistent inflammatory conditions. Because of the chronic nature of the disease, drugs with a good ratio of effectiveness to tolerability must be used. In the following double-blind study the effects of nimesulide, a non-steroidal antiinflammatory drug, were compared with those of placebo in 40 elderly osteoarthritic patients, during and after a treatment cycle of 90 days with two 100-mg tablets a day. The reduction of spontaneous and motion-induced pain and of morning stiffness seen at the various check-ups attested the good effectiveness of nimesulide. Functional status as a whole was improved, and it was found that the concomitant weekly intake of an analgesic (paracetamol) treatment could be decreased during the 3 months of the study. The tolerability of nimesulide was good.
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Banco de datos:
MEDLINE
Asunto principal:
Osteoartritis
/
Sulfonamidas
/
Antiinflamatorios no Esteroideos
Tipo de estudio:
Clinical_trials
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Int J Tissue React
Año:
1992
Tipo del documento:
Article
País de afiliación:
Italia