Probiotics in the treatment of atopic eczema/dermatitis syndrome in infants: a double-blind placebo-controlled trial.
Allergy
; 60(4): 494-500, 2005 Apr.
Article
en En
| MEDLINE
| ID: mdl-15727582
ABSTRACT
BACKGROUND:
Probiotic bacteria are suggested to reduce symptoms of the atopic eczema/dermatitis syndrome (AEDS) in food-allergic infants. We aimed to investigate whether probiotic bacteria have any beneficial effect on AEDS.METHODS:
Follow-up of severity of AEDS by the Severity Scoring of Atopic Dermatitis (SCORAD) index in 230 infants with suspected cow's milk allergy (CMA) receiving, in a randomized double-blinded manner, concomitant with elimination diet and skin treatment, Lactobacillus GG (LGG), a mixture of four probiotic strains, or placebo for 4 weeks. Four weeks after the treatment, CMA was diagnosed with a double-blind placebo-controlled (DBPC) milk challenge in 120 infants.RESULTS:
In the whole group, mean SCORAD (at baseline 32.5) decreased by 65%, but with no differences between treatment groups immediately or 4 weeks after the treatment. No treatment differences were observed in infants with CMA either. In IgE-sensitized infants, however, the LGG group showed a greater reduction in SCORAD than did the placebo group, -26.1 vs-19.8 (P=0.036), from baseline to 4 weeks after the treatment. Exclusion of infants who had received antibiotics during the study reinforced the findings in the IgE-sensitized subgroup.CONCLUSION:
Treatment with LGG may alleviate AEDS symptoms in IgE-sensitized infants but not in non-IgE-sensitized infants.
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Banco de datos:
MEDLINE
Asunto principal:
Hipersensibilidad a la Leche
/
Probióticos
/
Dermatitis Atópica
Tipo de estudio:
Clinical_trials
Límite:
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Allergy
Año:
2005
Tipo del documento:
Article
País de afiliación:
Finlandia