Evidence for a different sensitivity to various central effects of interleukin-1 beta in mice.
Brain Res Bull
; 28(2): 161-5, 1992 Feb.
Article
en En
| MEDLINE
| ID: mdl-1596738
ABSTRACT
Interleukin 1 (IL-1) induces a series of metabolic and endocrine effects. Activation of the hypothalamus-pituitary-adrenal axis, inhibition of food and water intake, elevation of serum interleukin-6 (IL-6) concentration and hypoglycemia are some of the effects induced by IL-1. The purpose of this study was to compare the sensitivity of these effects following central and peripheral administration of IL-1 beta. Different doses of IL-1 beta (0.1-1000 ng/mouse) were centrally (ICV) or peripherally (IP) injected to male mice two hours prior to sacrifice. The ICV administration was more efficacious than the IP injection in elevating serum corticosterone and IL-6 concentrations, whereas no difference was evident in the IL-1 beta-induced hypoglycemia. Central IL-1 beta administration was also more potent than IP injection in inhibiting overnight food and water intake. A dose-dependent effect was evident in all these cases. In summary, our data compare effects elicited by central or peripheral administration of different doses of IL-1 beta. This comparison suggests that the IL-1 beta stimulation of serum corticosterone and IL-6 and inhibition of food and water intake are events more centrally mediated than the IL-1 beta-induced hypoglycemia.
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Banco de datos:
MEDLINE
Asunto principal:
Glucemia
/
Corticosterona
/
Ventrículos Cerebrales
/
Interleucina-6
/
Interleucina-1
/
Conducta de Ingestión de Líquido
/
Conducta Alimentaria
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Brain Res Bull
Año:
1992
Tipo del documento:
Article
País de afiliación:
Italia