Macrophage migration inhibitory factor: controller of systemic inflammation.
Crit Care
; 10(2): 138, 2006.
Article
en En
| MEDLINE
| ID: mdl-16677407
ABSTRACT
Macrophage migration inhibitory factor (MIF) is a cytokine that is secreted by the anterior pituitary and immune cells in response to surgical stress, injury, and sepsis. This cytokine appears to be a critical regulator of the inflammatory pathways, leading to systemic inflammatory response syndrome and subsequent multiple organ dysfunction syndrome. This report provides an integrated scheme describing the manner by which MIF controls the neurohormonal response and the adaptive immune system, namely the T-helper (Th)1 and Th2 lymphocytes, which results in the release of pro-inflammatory cytokines and the anti-inflammatory cytokine interleukin-10. The development of systemic inflammatory response syndrome and subsequent development of multiple organ dysfunction syndrome appear to be related to MIF levels and the balance of Th1 and Th2 function.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Factores Inhibidores de la Migración de Macrófagos
/
Síndrome de Respuesta Inflamatoria Sistémica
/
Mediadores de Inflamación
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Crit Care
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos