The effect of insulin suppression on postprandial nutrient metabolism: studies with infusion of somatostatin and insulin.
Eur J Clin Nutr
; 45(11): 515-26, 1991 Nov.
Article
en En
| MEDLINE
| ID: mdl-1685991
ABSTRACT
Utilization of fat, carbohydrate and protein before and after feeding was studied in six healthy subjects using simultaneous respiratory gas exchange measurement and [1-13C] leucine infusion. The role of insulin was investigated by repeating a control study with the addition of an infusion of somatostatin, a hormone which can suppress insulin release. Where near-complete insulin suppression was effected, subjects were studied on a third occasion with the further addition of exogenous insulin infusion. The normal switch on feeding from fat to carbohydrate as principal energy source was reproduced at insulin levels of only 17%-33% of control values, which were inadequate to prevent hyperglycaemia. At fed levels below 10%, a fat-predominant pattern persisted unless insulin was infused. Protein degradation was reduced and synthesis unaffected by feeding, regardless of insulin concentration. Leucine oxidation was dependent on its plasma concentration in the presence of circulating insulin. Thus insulin appears to be necessary for the normal switch to carbohydrate oxidation on feeding but not for postprandial changes in protein metabolism.
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Banco de datos:
MEDLINE
Asunto principal:
Somatostatina
/
Proteínas
/
Intercambio Gaseoso Pulmonar
/
Insulina
/
Valor Nutritivo
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Eur J Clin Nutr
Asunto de la revista:
CIENCIAS DA NUTRICAO
Año:
1991
Tipo del documento:
Article
País de afiliación:
Reino Unido