Antibody binding is a dominant determinant of the efficiency of human immunodeficiency virus type 1 neutralization.
J Virol
; 80(22): 11404-8, 2006 Nov.
Article
en En
| MEDLINE
| ID: mdl-16956933
ABSTRACT
Primary and laboratory-adapted variants of human immunodeficiency virus type 1 (HIV-1) exhibit a wide range of sensitivities to neutralization by antibodies directed against the viral envelope glycoproteins. An antibody directed against an artificial FLAG epitope inserted into the envelope glycoproteins of three HIV-1 isolates with vastly different neutralization sensitivities inhibited all three viruses equivalently. Thus, naturally occurring HIV-1 isolates that are neutralization resistant are not necessarily more impervious to the inhibitory consequences of bound antibody. Moreover, the binding affinity of the anti-FLAG antibody correlated with neutralizing potency, underscoring the dominant impact on neutralization of antibody binding to the envelope glycoproteins.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Anticuerpos Anti-VIH
/
VIH-1
Límite:
Humans
Idioma:
En
Revista:
J Virol
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos