2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K.
J Med Chem
; 50(4): 591-4, 2007 Feb 22.
Article
en En
| MEDLINE
| ID: mdl-17256925
ABSTRACT
Starting from the purine lead structure 1, a new series of cathepsin K inhibitors based on a pyrimidine scaffold have been explored. Investigations of P3 and P2 substituents based on molecular modeling suggestions resulted in potent cathepsin K inhibitors with an improved selectivity profile over other cathepsins.
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Banco de datos:
MEDLINE
Asunto principal:
Inhibidores de Proteasas
/
Pirimidinas
/
Cisteína Endopeptidasas
/
Modelos Moleculares
/
Catepsinas
/
Nitrilos
Límite:
Animals
Idioma:
En
Revista:
J Med Chem
Asunto de la revista:
QUIMICA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Suiza