Influence of the formulation on the tolerance profile of nanoparticle-bound doxorubicin in healthy rats: focus on cardio- and testicular toxicity.
Int J Pharm
; 337(1-2): 346-56, 2007 Jun 07.
Article
en En
| MEDLINE
| ID: mdl-17306479
ABSTRACT
A toxicological study of doxorubicin bound to poly(butyl cyanoacrylate) or human serum albumin nanoparticles coated with polysorbate 80 was performed in healthy rats. The doxorubicin formulations were injected at a therapeutic dose regimen (3 x 1.5 mg/kg with a 72 h interval), and the animals were followed up for 15 or 30 days. The overall result of this study suggests that the surfactant-coated nanoparticle formulations of doxorubicin have favorable toxicological profiles. Specifically, these formulations display a considerably reduced cardio- and testicular toxicity, as compared to a free drug.
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Banco de datos:
MEDLINE
Asunto principal:
Testículo
/
Albúmina Sérica
/
Portadores de Fármacos
/
Doxorrubicina
/
Enbucrilato
/
Nanopartículas
/
Corazón
/
Antibióticos Antineoplásicos
Límite:
Animals
Idioma:
En
Revista:
Int J Pharm
Año:
2007
Tipo del documento:
Article
País de afiliación:
Rusia