Homocysteine, folic acid and vitamin B12 concentration in patients with recurrent miscarriages.
Neuro Endocrinol Lett
; 28(4): 507-12, 2007 Aug.
Article
en En
| MEDLINE
| ID: mdl-17693963
ABSTRACT
OBJECTIVES:
The aim of the project was the assessment of clinical usefulness of the determination of blood serum homocysteine concentration, folic acid and vitamin B12 in recurrent miscarriages.METHODS:
30 non-pregnant women with recurrent miscarriages (examined group-I) and for 20 non-pregnant women without obstetric failures in medical history (control group-II) were examined.RESULTS:
In the examined group (group I), the average concentration of homocysteine (9,45 micromol/l) was not statistically higher in comparison to the control group (group II) (8,47 micromol/l) (p>0,05). In group I the average vitamin B12 concentration in blood serum was 178,3 pg/ml and it was statistically lower (p<0,001) in comparison with the control group (II) (268,6 pg/ml). Such a relation was not observed for the vitamin B12, where the average concentration of this parameter was not dependent on the miscarriage number. A high negative correlation (R= -0,5397, p<0,01) was observed between the level of folic acid and homocysteine concentration in the group of women with recurrent miscarriages and a very high negative correlation (r = -0,9586 p<0,001) in the control group. No relation (R=0,0992 p>0,05) between the average concentration of vitamin B12 in blood serum and the average homocysteine in the nullipara group with recurrent miscarriagesCONCLUSIONS:
Together with the increasing number of abortions, the average homocysteine concentrations grew and the average folic acid concentrations lowered.
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Banco de datos:
MEDLINE
Asunto principal:
Vitamina B 12
/
Aborto Habitual
/
Ácido Fólico
/
Homocisteína
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Neuro Endocrinol Lett
Año:
2007
Tipo del documento:
Article
País de afiliación:
Polonia