[Effect of ulinastain on the expression of hemeoxygenase-1 in oleic acid-induced acute lung injury in rats].
Zhong Nan Da Xue Xue Bao Yi Xue Ban
; 32(4): 675-8, 2007 Aug.
Article
en Zh
| MEDLINE
| ID: mdl-17767064
ABSTRACT
OBJECTIVE:
To explore the effect of ulinastain on the expression of hemeoxy genase-1 (HO-1) in oil acid-induced acute lung injury in rats.METHODS:
The animal model of acute lung injury was established by oil acid. Thirty SD rats were randomly divided into 3 groups the blank control group (A), the acute lung injury group (B) and the acute lung injury group (C) followed by injecting 100 mL/kg ulinastatin. Each group consisted of 10 rats. Group A were given 0.2 mL/kg natural solution through the trial vein; Group B and C were given 0.2 mL/kg oil-acid through trial vein, while group C were injected 100mL/kg ulinastatin by the peritoneal cavity after injecting oil acid. After 4 hours, the rates of respiration were counted and blood samples were cramped out through the heart puncture for blood gas analysis. The expressions of hemeoxygenase-1 and the pathologic construction changes were determined by HE staining in the lower right lung of rats in the 3 groups.RESULTS:
The respiration dysfunction caused by oil acid could be prominently improved by ulinastain. There was only a little expression of hemeoxygenase-1 in the lung of Group A, but the expression increased in Group B and significatively increased in Group C.CONCLUSION:
Ulinastatin may protect the rats from acute lung injury through increasing the expression of HO-1.
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Banco de datos:
MEDLINE
Asunto principal:
Glicoproteínas
/
Lesión Pulmonar Aguda
/
Hemo Oxigenasa (Desciclizante)
/
Pulmón
Límite:
Animals
Idioma:
Zh
Revista:
Zhong Nan Da Xue Xue Bao Yi Xue Ban
Asunto de la revista:
MEDICINA
Año:
2007
Tipo del documento:
Article
País de afiliación:
China