Crystallization and preliminary X-ray data analysis of beta-alanine synthase from Drosophila melanogaster.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 63(Pt 10): 874-7, 2007 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-17909293
ABSTRACT
Beta-alanine synthase catalyzes the last step in the reductive degradation pathway for uracil and thymine, which represents the main clearance route for the widely used anticancer drug 5-fluorouracil. Crystals of the recombinant enzyme from Drosophila melanogaster, which is closely related to the human enzyme, were obtained by the hanging-drop vapour-diffusion method. They diffracted to 3.3 A at a synchrotron-radiation source, belong to space group C2 (unit-cell parameters a = 278.9, b = 95.0, c = 199.3 A, beta = 125.8 degrees) and contain 8-10 molecules per asymmetric unit.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Proteínas de Drosophila
/
Amidohidrolasas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Acta Crystallogr Sect F Struct Biol Cryst Commun
Año:
2007
Tipo del documento:
Article
País de afiliación:
Suecia