Pro-healing drug-eluting stents: a role for antioxidants?
Clin Sci (Lond)
; 114(4): 265-73, 2008 Feb.
Article
en En
| MEDLINE
| ID: mdl-18194135
ABSTRACT
Current strategies to lower the incidence of ISR (in-stent restenosis) following PCI (percutaneous coronary intervention) are aimed at modifying arterial healing after stent injury. This can impair endothelial recovery and render the vessel prone to acute thrombosis. As early restoration of endothelial integrity inhibits neointimal growth and thrombosis, alternative approaches which encourage this process may provide a more effective long-term result after PCI. Oxidative stress is enhanced after PCI and participates in the regulation of endothelial regeneration and neointimal growth. Moreover, evidence suggests antioxidants improve re-endothelialization and inhibit ISR. By promoting, rather than blocking, the healing process, antioxidant and other therapies may offer an alternative or additional approach over the antiproliferative approaches common to many current devices.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Reestenosis Coronaria
/
Stents Liberadores de Fármacos
/
Oclusión de Injerto Vascular
/
Antioxidantes
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
Clin Sci (Lond)
Año:
2008
Tipo del documento:
Article
País de afiliación:
Reino Unido