Tenacigenin B derivatives reverse P-glycoprotein-mediated multidrug resistance inHepG2/Dox cells.
J Nat Prod
; 71(6): 1049-51, 2008 Jun.
Article
en En
| MEDLINE
| ID: mdl-18512984
ABSTRACT
Tenacissimoside A (1) and 11alpha-O-benzoyl-12beta- O-acetyltenacigenin B (2), two derivatives of tenacigenin B (3) from the plant Marsdenia tenacissima, reversed multidrug resistance in P-glycoprotein (Pgp)-overexpressing multidrug-resistant cancer cells. The sensitivity of HepG2/Dox cells to the antitumor drugs doxorubicin, vinblastine, puromycin, and paclitexel was increased by 18-, 10-, 11-, and 6-fold by 20 microg/mL (or 25 microM) of 1 and 16-, 53-, 16-, and 326-fold by 20 microg/mL (or 39 microM) of 2, respectively. A preliminary mechanistic study has suggested that 1 might modulate Pgp-mediated multidrug resistance through directly interacting with the Pgp substrate site.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Plantas Medicinales
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Esteroides
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Medicamentos Herbarios Chinos
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Miembro 1 de la Subfamilia B de Casetes de Unión a ATP
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Proteínas Asociadas a Resistencia a Múltiples Medicamentos
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Marsdenia
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Antineoplásicos Fitogénicos
Límite:
Humans
Idioma:
En
Revista:
J Nat Prod
Año:
2008
Tipo del documento:
Article